Exam 2 Spectrum of Activity Summary

Question 1

Penicillin G

Answer 1

• gram +
• gram -
• anaerobes

Question 2

Nafcillin

Answer 2

• gram +

Question 3

Ampicillin

Answer 3

• gram +
• gram -
• anaerobes

Question 4

Unasyn
Augmentin

Answer 4

• gram +
• gram -
• anaerobes

Question 5

Ticarcillin

Answer 5

• gram -

Question 6

Pipercillin

Answer 6

• gram +
• gram -
• anaerobes

Question 7

Timentin
Zosyn

Answer 7

• gram +
• gram -
• anaerobes

Question 8

1st gen cephalosporins
(cephazolin, cephalexin)

Answer 8

• gram +
• gram -
• anaerobes (ADA)

Question 9

2nd gen cephalosporins
(cefuroxime, cefprozil, carbacephems, cephamycins, cefoxitin, cefotetan)

Answer 9

• gram +
• gram -
• anaerobes (ADA) (cefoxitin, cefotetan only)

Question 10

3rd gen cephalosporins
(ceftriaxone, ceftazidime, cefpodoxime)

Answer 10

• gram +
• gram -
• anaerobes (ADA)

Question 10

4th gen cephalosporins
(cefepime)

Answer 10

• gram +
• gram -
• anaerobes (ADA)

Question 10

Anti-MRSA ceftaroline

Answer 10

• gram +
• gram -
• anaerobes (ADA)

Question 10

cefiderocol
ceftazidime-avibactam
ceftaroline
ceftolozane-tazobactam

Answer 10

• gram +
• gram -
• anaerobes (ADA)

Question 10

Carbapenems

Answer 10

• gram +
• gram -
• anaerobes (ADA & BDA)

Question 10

FQ - cipro

Answer 10

• gram +
• gram -
• anaerobes (legionella only)

Question 11

Monobactams (aztreonam)

Answer 11

• gram -

Question 11

FQ - levo, moxi, dela

Answer 11

• gram +
• gram -
• ADA & legionella

Question 12

Macrolides

Answer 12

• gram +
• gram -
• ADA, legionella, treponema

Question 13

Aminoglycosides

Answer 13

• gram + (not alone!!!)
• gram -

Question 14

Vancomycin

Answer 14

• gram +
• (no gram - activity)
• ADA
• Cdiff (PO only)

Question 15

Synercid, Linezolid, Tedizolid, Daptomycin, Telavancin, Dalbapristin, Oritavancin

Answer 15

• gram +
• ADA

Question 16

Tetracyclines

Answer 16

• gram +
• gram -
• ADA, legionella, treponema

Question 17

Tigecycline, Eravacycline, Omadacycline

Answer 17

• gram +
• gram -
• ADA & BDA

Question 18

TMP-SMX

Answer 18

• gram +
• gram -

Question 19

Colistin (Polymixin E)
Polymixin B

Answer 19

• gram -
  (no gram + activity)

Question 20

Clindamycin

Answer 20

• gram +
• (no gram - activity)
• ADA & BDA

Question 21

Metronidazole

Answer 21

• (no aerobic activity)
• ADA, BDA, Cdiff

Question 22

Drugs for PRSP

Answer 22

• 3rd gen cephalosporins (ceftriaxone and cefotazime only)
• 4th gen cephalosporins (cefipime, NOT cefiderocol)
• Anti-MRSA ceftaroline
• FQ: levo, moxi, dela
• Vancomycin
• syner,linez, tediz, dapt, tela, dalb, orita

Question 23

Drugs for VRE

Answer 23

• linezolid
• daptomycin
• Synercid only against VRE faecium
• telavancin/dalbavancin vs some VRE

Question 24

Drugs for MSSA

Answer 24

• Nafcillin
• Unasyn, Augmentin
• 1st, 2nd, 3rd, 4th gen cephalosporins (not cefiderocol), ceftaroline
• carbapenems
• cipro (sometimes)
• levo, moxi, dela
• aminoglycosides
• vancomycin & other GP agents
• tetracyclines
• bactrim
• clindamycin

Question 25

Drugs for MRSA

Answer 25

• anti-MRSA ceftaroline
• delafloxacin
• aminoglycosides (not alone)
• vancomycin (primary agent)
• other GP agents
• tetracyclines (sometimes)
• bactrim
• clindamycin (CA-MRSA)

Question 26

Drugs for Pseudomonas

Answer 26

• ticarcillin
• piperacillin
• Timentin or Zosyn
• 3rd and 4th gen cephalosporins
• ceftol, tazo, cefta, av
• carbapenems (not ertapenem)
• monobactams
• FQ: cipro, levo, dela
• aminoglycosides
• Polymixin B and Colostin

Question 27

Drugs for BDA

Answer 27

• Unasyn, Augmentin
• piperacillin (sometimes)
• Timentin, Zosyn
• cefoxitin, cefotetan, cef
• carbapems
• metronidazole

Question 28

Drugs for C diff

Answer 28

• vancomycin (PO only)
• metronidazole

Question 29

Drugs for Legionella

Answer 29

• FQs
• macrolides
• tetracyclines (tet, doxy, mino)