Exam #2 - Sex Determination

Question 1

What chromosomes define MALE?

Answer 1

XY

Question 2

What chromosomes define FEMALE?

Answer 2

XX

Question 3

What chromosomes define Turner Syndrome?

Answer 3

XO

Question 4

What chromosomes define Klinefelter Syndrome?

Answer 4

XXY

Question 5

Explain Turners Syndrome

Answer 5

• XO
• develops in ovary
• loss of follicle cells
• Ovarian dysgenesis
• Webbed neck

Question 6

Explain Klinefelter’s syndrome

Answer 6

• XXY
• Testis form normally
• most germ cells die when enter meiosis
• 1/1000 burths

Question 7

Which chromosome determines sex? What’s the determination if it’s present or absent?

Answer 7

• Y chromosome
• present = malde gonads (testis)
• absent = female gonads (ovary)

Question 8

TRUE or FALSE

The # of X chromosomes does NOT affect primary sex determination.

Answer 8

TRUE

Question 9

Which chromosome contains the SRY gene

Answer 9

Y chromosome

Question 10

Define SRY gene and location

Answer 10

• “controller gene “
  Location = tip of short arm of. Y chromosome
  (Sex determination region)

Question 11

Androgen Insensitivity Syndrome is…

Answer 11

• inability to respond to androgens
• genetically male but has female genitals

Question 12

Congenital adrenal hyperplasia is…

Question 13

TRUE or FALSE

In normal secondary sex determination MALES have Wolffian Ducts

Answer 13

TRUE

Wolffian ducts develop into the male internal genitalia, including the epididymis, vas deferens, and seminal vesicles

Question 14

What’s the difference between PRIMARY sex determination and SECONDARY sex determination.

Answer 14

• PRIMARY: development of the gonads (ovaries & testies) and structures
• SECONDARY: overall appearance of organism, external genitalia and mammary glands

Question 15

Leydig Cells are…

Answer 15

• primary source of testosterone or androgens in males
  (Secrete testosterone/androgens)
• help in sperm production

Question 16

Sertoli Cells do what?

Answer 16

• secrete MIH
• regulate and maintain sperm integrity