Exam 2: Infection, Pre,Post-Op Flashcards
The body’s ability to resist disease is known as what?
Immunity
What are some reasons for wide spread distribution of emerging infections?
Global travel
Population density
Encroachment into new environments
Misuse of antibiotics
This occurs when a pathogenic organisms change in ways that decrease the ability of a drug to treat the disease
Resistance
How have HCPs contributed to the development of drug resistance microorganisms?
- Giving antibiotics for viral infections
- Succumbing to patient pressure to prescribe unnecessary antibiotic therapy
- Using inadequate drug regimens to treat infections
- Using broad spectrum or combination agents for infections that should be treated w/ first-line medications (over-treating)
How can patients contribute to the development of drug resistance microorganisms?
- Skipping doses
- Not taking antibiotics for the full duration
- Saving unused antibiotics “in case I need them later”
A viral infection is NOT treated with what?
Antibiotics
What are some patient and caregiver teaching to prevent antiobiotic resistance?
- Only take antibiotics prescribed to you
- Wash hands frequently (prevention)
- Follow directions when taking antibiotics
- Don’t request an antibiotic for flu or cold (not effective against viral)
- Finish your antibiotic (bacteria will survive, multiply, and then be harder to kill)
- Do not take left over antibiotics (may not be effective for new illness, may not be as effective if older, may not be enough doses left)
Infections in older adults may have atypical manifestations such as what?
Cognitive and behavioral changes BEFORE emergence of fever, pain, changes in lab values.
This type of precaution is used for infections spread by small particles in the air (chicken pox, measles, TB)
Airborne:
- N95
- Gown
- Gloves
- Eye protection
This type of precaution is used for infections spread in large _____ by coughing, talking, or sneezing. (Influenza and bacterial meningitis)
Droplet:
- Mask
- Gown
- Gloves
- Eye protection
This type of precaution is used for infections spread _____ (skin-to-skin or infected surfaces). C-diff, MRSA
Contact
- Gown
- Gloves
What are three functions of the immune system?
- Defense
- Homeostasis
- Surveillance
In the defense function of the immune system, what occurs?
- The body protects against invasions / prevents development of infection by attacking foreign antigens and pathogens
During the homeostasis function of the immune system, the body does what?
Digests and removes damaged cellular substances
- Goal is to have the body’s different type of cell types stay uniform and unchanged
During the surveillance function of the immune system, what are recognized and destroyed?
Mutations - recognized as foreigns cells and destroyed as result
____ are substances that elicit an immune response.
These are made of protein, found on each cell, are unique to the person so the body can recognize itself.
Antigens
Wha are the two ways immunity can be classified?
Innate and acquired
What type of immunity am i:
- Present at birth
- First line defense against pathogens
- Involves a nonspecific response: (WBC response includes neutrophils and monoctyes)
- NOT antigen specific so response can occur within minutes
- No previous exposure is needed for response to occur
Innate immunity
What type of immunity am i?:
- Development of antibodies as the result of an invasion of a foreign substance: BODY MAKES ANTIBODIES ITSELF!
- Each re-invasion results in a faster and stronger response
- May result naturally or artificially
- Immunity takes time because body is making antibodies, but is long lasting
- Memory cells present for antigen
Active acquired
What are some examples of active acquired immunity?
Vaccine
Bee sting
What type of immunity am i?:
- Host RECEIVES antibodies rather than making them
- Occurs injection w/ gamma globulin (serum antibodies)
- Has immediate effect but short lasting because people doesn’t make antigen and memory cells themselves
Passive acquired immunity
What is an example of passive acquired immunity?
Transfer of immunoglobulins across placental membrane
What is the process of the immune response to a virus?
- Virus invades body thru break in the skin and into cell
- Macrophage recognizes antigens on the surface of virus, digests it and displays virus (antigens) on its surface
- T helper cells recognizes the antigen displayed and binds to the macrophages, stimulating production of cytokines -> communication begins
- Cytokines instruct T helper cells and T cytotoxic cells to multiply. T heller cells release additional cytokines that cause B cells to multiply and make antibodies
- T cytotoxic cells and natural killer cells destroy infected body cells
- Antibodies bind to virus and mark it for destruction by macrophages
- Memory B and T cells stay behind to respond quickly if same virus attacks again
Role of mononuclear phagocytes in the immune response
- Include monocytes in blood and macrophages in the body
- Capture, process, and present antigen to lymphocyte (T or B), which stimulates the immune response
B lymphocyte is found in what immunity:
A. Cell-mediated
B. Hummoral
B. Hummoral
T lymphocytes are found in what immunity:
A. Cell-mediated
B. Hummoral
A. Cell-mediated
______ act as messengers among the cell types and instruct cells to alter their proliferation, differentiation, secretion, or activity.
Cytokines
What is the major difference between cell-mediated and humoral immunity?
In humoral immunity, antibodies and B-cells drive the response while T-cells drive the response in cell-mediated
What are the types of hypersensitivity reactions?
Type I: IgE-Mediated
Type II: Cytotoxic
Type III: Immune-Complex
Type IV: Delayed Hypersensitivity
What type of hypersensitivity reaction am i:
Type I: IgE-Mediated
Urticaria and Anaphylaxis are examples of what type of hypersensitivity reaction
Type I: IgE-Mediated
What type of hypersensitivity reaction am i:
ANTIGEN: Cell surface of RBCs
RATE OF DEVELOPMENT: minutes to hours
MEDIATORS: complement lysis, macrophages in tissues
EXAMPLES: Tranfusion issues, goodpasture syndrome, graves’ disease
Type II: Cytotoxic
Graves disease and blood transfusion reactions are examples of what hypersensitivity reaction?
Type II: Cytotoxic
What hypersensitivity reaction am i:
ANTIGEN: extracellular fungal, viral, bacterial
RATE OF DEVELOPMENT: hours to days
MEDIATORS: neutrophils, monocytes, macrophages, complement lysis
EXAMPLES: SLE, RA, Acute glomerulonephritis
Type III: Immune-Complex
What hypersensitivity am i:
ANTIGEN: Intracellular, extracellular
RATE OF DEVELOPMENT: over SEVERAL DAYS
MEDIATORS: cytokines and T cytotoxic cells
EXAMPLES: Contact derm
Type IV: Delayed Hypersensitivity
Contact dermatitis is an example of what kind of hypersensitivity reaction?
Type IV: Delayed Hypersensitivity
Wheal and flare is associated with what type of hypersensitivity reaction?
Type I: IgE-Mediated
TB test reaction is related to what hypersensitivity reaction?
Type IV: Delayed Hypersensitivity
What are the interventions for Anaphylaxis
- Epinephrine is the drug of choice (does have short half-life, sometimes needs to be followed by second injection & albuterol)
- Oxygen is another intervention
Nursing assessment for allergic response: subjective data
Past health hx:
* Reccurent respiratory problems
* Seasons exacerbations
* Unusual reactions to insect bites / stings
* Past / present allergies
* Food intolerances -> What food, what reaction
* Family hx of allergic reactions
Medications:
* Unusual reactions to any medications: WHAT IS THE ALLERGY
* Use of OTC or Rx medications for allergies -> how often
Social & Environmental
* Pets, trees, plants on property
* Polluntants in air: what environment are they around most
* Cooling and heating systems in the house -> how often are they checked
* Home environment: dust?
Nursing assessment for allergic response: objective data
Integumentary
* rashes, urticaria, papules, dryness, scaliness, scratching, irritation
EENT
* Eyes: conjunctivities, rubbing/excessive blinking, dark circles under eyes -> “allergic shiner”
* Ears: diminshed hearing, reccurent ear infections, scarred tympanic membranes
* Nose: polyps, itchy/running nose, sneezing, repeated sneezing, recurrent nose bleeds swollen nasal passages
* Throat: continued throat clearing, swollen lips/tongue, palpable lymph nodes
Respiratory
* Wheeezing, stridor, thick sputum
What are some diagnostic studies that can be used with allergies?
- WBC: used to diagnose immunodeficiency
- Test Sputum, nasal and bronchial secretions for presence of eosinophils (will be increased in allergic reactions)
- Skin testing for specific allergens
What are some teaching / interventions that can be done w/ allergen recognition and control?
*** Need to identify offending allergn **
* Unlikely that pt will be totally desensitized or completely symptom free
* Environmental control: changing occupation, moving to different climate, sleeping in air conditioned room, dusting daily, covering mattresses/pillows w/ hypoallergic covers, wearing mask outdoors
* Medications available, may need to be used -> provide education on use, s/e, etc.
*
What are the major categories of drugs used for symptomatic relief of allergies?
- Antihistamines
- Corticosteroids
- Antipuritic
Allergy relief: antihistamines
- Best for allergic rhinitis & uriticaria, edema, pruritus –> not for severe reactions
- Complete w/ histamine receptor sites, block histamine effect
- Best if taken as soon as allergy symptoms appear
Cimeditine, Diphenhydramine, Famotidine
Allergy relief: Corticosteroids
- Effective in relieving allergic rhinitis
- Nasal or oral options
Allergy relief: Antipyretic
- Used for discomfort but do not reduce the allergy response
- Applied topically
Calamine lotion, Menthol
Allergy relief: Epinephrine
- Very short term, needs to be followed up by other meds such as corticosteroids or antihistamines -> HAS SHORT HALF-LIFE, MORE THAN ONE INJECTION MAY BE NEEDED
- Administered either IM, 90 degrees into top of thigh slightly to the outside. Hold in place 2-3 seconds
- Allergy bracelets should be worn notify others about allergy and med to use
What are some sample questions to ask a patient during an allergy assessment?
- Tell me more about your allergies
- What were your previous allergic reactions like
- What do you currently use to help control your allergies
ALWAYS OPEN-ENDED AND THERAPEUTIC
What is the difference between a side effect and an allergy?
- An allergy is an adverse drug reaction mediated by an immune response (e.g., rash, hives).
- A side effect is an expected and known effect of a drug that is not the intended therapeutic outcome.
Hives, anaphylactic shock, cardiopulmonary compromise are an example of:
A. Side effect
B. Allergic reaction
B. Allergic reaction
Nausea, constipation, diarrhea, idiosyncratic reactions are examples of
A. Side effects
B. Allergic reactions
A. Side effects