Exam 2 - important numbers Flashcards
E1/2t and clearnece of thiopental and methohexitol
- E1/2t and clearnace d/t hepatic metabolism
-
Thiopentoal
- E1/2 = 11.6 hours
- Clearnace = 3.4 ml/kg/min
-
Methohexitol
- E1/2 = 3.9 hours
- Clearnace = 10.9 ml/kg/min
% nonionized at 7.4 for thiopental and methohexatol
Thiopentol = 61%
Methohexatol = 76%
Relative dosages of methohexatol and thiopental
Thiopental Dose
- IV: 3-5mg/kg
- Elderly = Decrease
- Peds IV: 5-6 mg/kg
- Infants: 7-8 mg/kg
Methohexatol
- IV: 1-2 mg/kg
- Peds Rectal: 20-30 mg/kg
- pKA = 7.9
- % NON-ionized at physoplogic pH = 23%
Morphine
pKA = 8.5
% NON-ionized at physoplogic pH = 7%
Meperedine (Demerol)
pKA = 8.4
% NON-ionized at physoplogic pH = 8.5%%
Fentanyl
pKA = 8.0
% NON-ionized at physoplogic pH = 20%
Sufentanil
pKA = 6.5
% NON-ionized at physoplogic pH = 89%
Alfentanil
pKA = 7.3
% NON-ionized at physoplogic pH = 58%
Remifentanil
Protein binding = 35%
Morphine
Protein binding = 70%
Meperidine
Protein binding = 84%
Fentanyl
Protein binding = 93%
Sufentanil
Protein binding = 92%
Alfentanil
Protein binding = 66-93%
Remifentanil