EXAM 2 DRUG LIST

Question 1

Aspirin (acetylsalicylic acid)

Answer 1

• enteral route
• anti-inflammatory
• antithrombotic
  -metabolized by hydrolytic reactions in phase 1
• partially prodrug
• irreversible COX 1 inhibitor

-extra benefits: helps cardiovascular disorders, prostate cancer, Alzheimer’s
- alter’s balance of TXA2 and PG12 (promoters and inhibitors)
- selective for platelets which contai cox1
- Weak acid
-absorbed in ileum
-higher excretion is alkaline urine
-half- life 4-15h

Question 2

Doxycycline

Answer 2

• tetracycline antibiotic
  -inhibits 30S ribosome
• metabolized 60% in liver, 40% in kidneys

Question 3

Ciprofloxacin

Answer 3

• quinolone antibiotic
• inhibits DNA gyrase and topoisomers = inhibits DNA replication and transcription
• metabolized by liver

Question 4

Penicillin

Answer 4

• antibiotic
• can cross BBB when inflamed and administered via IV
• 1 transit via kidney = completely filtered

Question 5

Acetominophen

Answer 5

• paracetamol
  -not anti-inflammatory
• has toxic metabolite
• great analgesic and antipyretic
• inactivated in liver
• few side effects
• many overdoses
• considered enfocannabinomimetic

Question 6

Isotretinoin

Answer 6

• anti-acne
  -derivative of vitamin A
• first developed as chemo med.
• teratogen: causes birth defects

Question 7

Thalidomide

Answer 7

• sedative and hypnotic
• advertised to help with morning sickness
• children born with defects (phocomelia)

Question 8

Morphine

Answer 8

• parenteral route
• has Vd greater than total body volume
• uses presystemic metabolism
• recirculate using reservoir

Question 9

Beclomethasone

Answer 9

mucous mem route

Question 10

Nicotine

Answer 10

transdermal route

Question 11

curare

Answer 11

• block nicotinic acetylcholine receptors
  -SA or SB = poorly abs.

Question 12

Phenylalanine

Answer 12

amino acid

Question 13

Levedopa

Answer 13

-prodrug
-precursor to dopamine
- for parkinson’s disease
- uses phenylalanine transport mechanism
- absorbed in GI and crosses BBB

Question 14

tetracycline

Answer 14

• antibiotic
• don’t consume milk = binds to calcium = lower efficacy

Question 14

Propranolol

Answer 14

• beta blocker
• more effective after eating because food increases splanchnic blood flood.

Question 15

Warfarin

Answer 15

• anticoagulant
• decreased abs. when bound to bile acid - binding resins
• mixture of stereoisomers
• inactivated by reductive reactions

Question 16

Glyceryl trinitrate

Answer 16

• sublingual

Question 17

Phenylephrine

Answer 17

• nasal spray
• for congestion

Question 18

Progestin

Answer 18

• synthetic form of progesterone
• in transdermal contraceptive patch
• delivers norelgestromin hormone

Question 19

Estrongen

Answer 19

-sex hormone
- in transdermal contraceptive patch
- delivers ethinyl estradiol