EXAM 2 DRUG LIST Flashcards
1
Q
Aspirin (acetylsalicylic acid)
A
- enteral route
- anti-inflammatory
- antithrombotic
-metabolized by hydrolytic reactions in phase 1 - partially prodrug
- irreversible COX 1 inhibitor
-extra benefits: helps cardiovascular disorders, prostate cancer, Alzheimer’s
- alter’s balance of TXA2 and PG12 (promoters and inhibitors)
- selective for platelets which contai cox1
- Weak acid
-absorbed in ileum
-higher excretion is alkaline urine
-half- life 4-15h
2
Q
Doxycycline
A
- tetracycline antibiotic
-inhibits 30S ribosome - metabolized 60% in liver, 40% in kidneys
3
Q
Ciprofloxacin
A
- quinolone antibiotic
- inhibits DNA gyrase and topoisomers = inhibits DNA replication and transcription
- metabolized by liver
4
Q
Penicillin
A
- antibiotic
- can cross BBB when inflamed and administered via IV
- 1 transit via kidney = completely filtered
5
Q
Acetominophen
A
- paracetamol
-not anti-inflammatory - has toxic metabolite
- great analgesic and antipyretic
- inactivated in liver
- few side effects
- many overdoses
- considered enfocannabinomimetic
6
Q
Isotretinoin
A
- anti-acne
-derivative of vitamin A - first developed as chemo med.
- teratogen: causes birth defects
7
Q
Thalidomide
A
- sedative and hypnotic
- advertised to help with morning sickness
- children born with defects (phocomelia)
8
Q
Morphine
A
- parenteral route
- has Vd greater than total body volume
- uses presystemic metabolism
- recirculate using reservoir
9
Q
Beclomethasone
A
mucous mem route
10
Q
Nicotine
A
transdermal route
11
Q
curare
A
- block nicotinic acetylcholine receptors
-SA or SB = poorly abs.
12
Q
Phenylalanine
A
amino acid
13
Q
Levedopa
A
-prodrug
-precursor to dopamine
- for parkinson’s disease
- uses phenylalanine transport mechanism
- absorbed in GI and crosses BBB
14
Q
tetracycline
A
- antibiotic
- don’t consume milk = binds to calcium = lower efficacy
14
Q
Propranolol
A
- beta blocker
- more effective after eating because food increases splanchnic blood flood.
