Exam 2 - Chapter 14 Flashcards

1
Q

Granulocytes

A

Neutrophils, Basophils, Eosinophils

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2
Q

Neutrophils

A

Over half of white blood cells. They engulf and destroy bacteria by phagocytosis. Their granules stain poorly. Found mostly in the blood, not tissues

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3
Q

Basophils

A

Involved with allergic reactions and inflammation. Stain dark blue

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4
Q

Eosinophils

A

Remove parasitic worms and involved with symptoms of allergies. Stain red

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5
Q

Mast Cells

A

Like Basophils but are found in tissues, not blood

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6
Q

Surface Receptors

A

Proteins that float on the cytoplasm, therefore in contact with the inside and outside of the cell. The molecules that bind to them allow them to transmit information. Induces changes such as chemotaxis

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7
Q

Ligands

A

The molecules that bind to surface receptors

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8
Q

Cytokines

A

Produced by one cell and diffuses to another, binding to the cytokine receptor. Induces changes such as growth or death

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9
Q

Pattern Recognition Receptors (PRR’s)

A

Detect an invasion from foreign materials and produce cytokines to signal other cells

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10
Q

Microbe-Associated Molecular Patterns (MAMP’s)

A

The microbes that PRR’s detect

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11
Q

Danger-Associated Molecular Patterns (DAMP’s)

A

Microbes that indicate host cell damage

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12
Q

Cytoplasmic PRR’s

A

RIG-like Receptors (RLR’s) and NOD-like Receptors (NLR’s)

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13
Q

RIG-like Receptors (RLR’s)

A

Cytoplasmic proteins that detect viral RNA

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14
Q

Toll-like Receptors (TLR’s)

A

PRR’s found on the cell surface, and in phagosomes and endosomes. Recognize distinct compounds associated with microbes

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15
Q

NOD-like Receptors (NLR’s)

A

Cytoplasmic proteins that detect compounds or cell damage. During invasion, they combine with other proteins to make an inflammasome, which causes inflammation

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16
Q

Interferon (IFN)

A

A compound that causes nearby cells to enter an antiviral state to protect themselves from viral infection

17
Q

iAVP

A

Inactive Antiviral Proteins. When an interferon binds to another cell, the cell makes these inactive enzymes or iAVP’s. These enzymes are activated from dsRNA from viruses, and commit suicide for the cell by degrading mRNA, and therefore stopping protein synthesis, so infection doesn’t spread

18
Q

Complement System

A

Inactive proteins that circulate the blood and tissues. They become activated from invasion, and have specialized functions to stop infection. The complement system is caused by a complex C3 convertase, and has 3 pathways

19
Q

Alternative Pathway

A

C3b binds to foreign cells, signaling its protein “friends” to also come bind, forming C3 convertase

20
Q

Lectin Pathway

A

Mannose Binding Lectins (MBL’s) bind to mannose, a carb on invaders, to form C3 convertase

21
Q

Classical Pathway

A

When antibodies bind to antigens, the complement system forms the C3 convertase

22
Q

Immune Complex

A

Antibody-antigen complex

23
Q

Opsonization (Complement System)

A

Happens with the alternative pathway. Being opsonized means to be prepared for eating. So basically, molecules bind to the invader, and signal phagocytes to eat it. Phagocytes have an easier time eating things when it can bind to these opsonins

24
Q

Inflammatory Response (Complement System)

A

C5a causes endothelial cells to become less permeable, to let invaders out. It also causes mast cells to release pro-inflammatory cytokines, And it attracts phagocytes to come eat the invaders

25
Lysis of Foreign Cells (Complement System)
C5b-C9 join together in a "doughnut" called Membrane Attack Complexes (MAC's) in the membrane to form an opening. This causes the cell to die. They work better for Gram negative bacteria, not Gram positive. Because Gram positive bacteria membranes are too thick for it
26
Membrane Attack Complexes (MAC's)
The doughnut arrangement of C5b-C9
27
Chemotaxis
Phagocytes are recruited by chemoattractants. These are microorganisms, phospholipids, chemokines, and C5a
28
Engulfment
It attaches to the particle, wraps its pseudopods around it, and engulfs it in a phagosome
29
Interleukins (ILs)
Produced by leukocytes; important in innate and adaptive immunity
30
Tumor Necrosis Factor (TNF)
Inflammation, apoptosis
31
Colony-Stimulating Factors (CSF)
Multiplication and differentiation of leukocytes
32
Phagosome Maturation and Phagolysosome Formation
Endosomes fuse, lower pH; lysosomes bring enzymes
33
Destruction and Digestion
Toxic ROS and nitric oxide produced; pH decreases; enzymes degrade; defensins damage membrane of invader; lactoferrin ties up iron
34
Exocytosis
Vesicle fuses with cytoplasmic membrane, expels remains
35
Endogenous Pyrogens
Cytokines produced by macrophages following detection of microbial products by TLRs
36
Exogenous Pyrogens
Produced by microbes