Exam 2 (AKI, CKD) Flashcards
Criteria for CKD
If either of the following is present for >3 months
-Markers of kidney damage (one or more)
Albuminuria, urine sediment, electrolyte or other
disorders, H/O transplant, other
-Decreased GFR (<60mL/min)
What is the easiest way to know if a patient has CKD?
By monitoring decreased GFR using MDRD.
Can also assess protein in urine because that typically doesnt happen in AKI
Stages of CKD
1- Normal, GFR>90mL/min 2-Mildly decreased, GFR 60-89 3- Mild to moderate decrease, GFR 45-59 Moderate to severely decreased, GFR 30-44 4- Severe decreased GFR, GFR 15-29 5- Kidney Failure, GFR <15 or dialysis
What are the common causes of ESRD?
Diabetes and HTN are the main causes
Can also be because of glomerulonephritis
CKD susceptibility risk factors
Diabetes, HTN, Older age (>55), family history, racial or ethnic minority
Progression factors of CKD
higher levels of proteinuria Higher BP Poor glycemic control Smoking Hyperlipidemia Drugs Obesity
CKD complications
CVD
Anemia
Altered bone and mineral metabolism
Pathophysiology of CKD
Loss of nephron mass-damage due to one or more of the progression factors
Glomerular capillary HTN- mediated by AT II
Proteinuria- Both a marker of damage and can lead to further damage as proteins are toxic to tubular cells
If a patient had a recent infection, symptoms with urination, a skin rash, or arthritis, what might be the potential problem?
Post-step glomerulonephritis
UTI
Lupus
If a patient has chronic disease such as CHF, cirrhosis, diabetes, HTN, what might be the potential problem?
Prerenal CKD or CKD
If a patient has a family history, what might be the potential problem?
Polycystic kidney disease
What lab values should you measure for CKD patients?
Estimated GFR (at least annually)
BP
Urine examination (at least annually)
-Albumin:Cr ratio (UACR) in early morning urine
sample(Albuminuria if >30)
-Examination for casts, sediment, etc.
Imaging studies
What is progression of CKD defined as?
A drop in GFR more than 5mL/min/year
What are common CKD complications?
Anemia, HTN, Vit D deficiency, acidosis, hyperphosphatemia, hyperparathyroidism
What are interventions of CKD that can delay progression?
ACE-Is, ARBs, BP control, blood glucose control
How do ACE-Is and ARBs delay the progression of CKD?
They lower systemic blood pressure, thus lowering glomerular capillary blood pressure and protein filtration rate. They also reduce AT II mediated cell proliferation and fibrosis.
This is accomplished in very low doses.
What is the evidence of ACE-Is and ARBs in delaying progression of CKD?
Should be used if UAE >30mg/day with diabetes
Should be used in all CKD pts with UAE >300mg/day
Patiromer (Veltassa)
Non-absorbed cation exchange polymer (K+ binder, exchanges for Na)
Used in patients with chronic hyperkalemia associated with ACE/ARB use
8.4g QD- Space out from other oral medications by 3 hours
May cause constipation or diarrhea
Sodium Zirconium Cyclosilicate (Lokelma)
Used in patients with chronic hyperkalemia associated with ACE/ARB use.
Use this or Patiromer (Not both)
10mg TID- space out from other medications by at least 2 hours
May cause edema
What do we do if Cr increases more than expected when a patient is on an ACE or an ARB?
If increased 30-50%, reduce dose
If increased >50%, D/C
This is a dose related effect
Can ACE and ARBs be used together?
No
Too high of a risk for hypotension, hyperkalemia, and decrease in kidney function.
This combination could cause an AKI on top of a patients CKD.
ACE-Is and Aldosterone blockers in CKD
Avoid combination except in CHF patients because of the high risk of hyperkalemia
Diuretics in CKD
Generally necessary in most CKD patients to help control fluid volume and BP
Most CKD patients have hypernatremia so diuretics reduce the Na levels.
Diuretics work synergistically with ACEe/ARBs by activating RAAS and promoting fluid retention
When do you use which diuretic in CKD
Thiazides if CrCl >30ml/min
Loops for CrCl <30ml/min
Cautious use of K-sparing diuretics especially if pt is on an ACE/ARB or has CrCl <30ml/min
Overdoing diuresis can lead to decreased GFR