Exam 2 Flashcards
callous-unemotional traits
- lack of remorse or guilt
- lack of empathy
- unconcern about performance in important activities
- shallow or deficient affect
how are CU traits measured?
as set of traits, or diagnostically as a specifier of conduct disorder in the DSM
Conduct Disorder
clinical diagnosis characterized by: 1. aggression 2. destruction of property 3. deceitfulness 4. serious rule violations symptoms must occur before 18, unless in context of APD, before 16
ODD
pattern of negative, hostile, and defiant behavior
may have symptoms related to anger/irritability, may be argumentative/defiant/vindictive
ADHD
clinical diagnosis characterized by several inattentive or hyperactive-impulsive symptoms
comorbid with CD and ODD
adolescent limited CD
from Moffitt’s model; one pathway to CD where onset coincides with adolescence and is less likely to continue into adulthood; behavior may be exaggeration of normal adolescent rebellion process
life course persistent CD (5)
from Moffitt’s model; pathway where onset is early (6 years old) and continues into adulthood, where individuals are likely to have
- neuropsychological deficits
- cognitive deficits (IQ)
- temperament/personality risk factors
- genetic risk
- neural risk
ACC
neural area found to be important for flexible control of aversively motivated behavior; tracks outcomes of choices made in recent past and integrates reward info to allow adaptive modification of behavior
OFC
neural area found to be important for integrating signals and modulating activity of other brain regions. role in:
- representing affective value of reinforcers
- stimulus reinforcement learning
- decisionmaking
- executive function
amygdala
neural area found important for threat detection (“fear center”) and stimulus reinforcement learning, and esp as a salience motivation detector
ventral striatum
portion of striatum including 1. nucleus accumbens 2. olfactory tubercle 3. islands of Calleja reward center
dlPFC
neural area essential for executive functions (maintain/shift set, planning, response inhib, working memory, organization, reasoning, problem solving, abstract thinking)
MAOA
enzyme affecting NTs dopamine, NE, and 5HT
serotonin genes (5HTTLPR)
codes for serotonin transporter
COMT
modifying gene; role in modulating PFC dopamine levels, associated with subtypes of antisocial behavior
heritability
statistic used in genetics that estimated how much variation in a phenotypic trait in a population is due to genetic variation among individuals in that population
culpability (3)
culpable if cause a negative event act
- act was intentional
- act and consequences could have been controlled (agent knew likely consequences, was not coerced, and overcame hurdles to make event happen)
- person provided no excuse or justification for actions
mitigation
circumstances that may be considered by a court in determining culpability of a defendant or extent of damages to be awarded to a plaintiff
do not justify or excuse offense, but may reduce severity of charge
high MAOA + ___ leads to (2)
- maltreatment
2. proactive aggression and CU traits
low MAOA + ___ leads to
aggressive/impulsive behavior
pathway for low MAOA leading to aggression/impulsivity
+ maltreatment, leads to increased amygdala and decreased cortical response (increased availability of 5HT activates amygdala)
pathway for high MAOA leading to callous/proactive aggression
+ maltreatment, leads to decreased amygdala response (decreased availability of 5HT)
homozygous long allele for 5HTTLPR + ___ leads to…
+ low SES; high CU and narcissistic traits
homozygous short allele for 5HTTLPR + ___ leads to…
impulsivity
COMT val/met gene variant leads to…
conduct disorder
reduced amygdala activity leads to deficient response during…
affective empathy
maltreatment + ___ leads to CU traits
high MAOA
maltreatment + ___ leads to impulsive traits
low MAOA
low SES + ___ leads to CU traits
homozygous long allele for 5HTTLPR
low SES + ___ leads to impulsive traits
homozygous short allele for 5HTTLPR
high level of conduct problem traits associated with ___ amygdala response during affective empathy
higher
high level of CU traits associated with ___ amygdala response during affective empathy
lower
what 4 neural aberrations do children with CP+CU display?
- reduced amygdala functioning
- reduced vmPFC activation
- reduced OFC activation
- poor amygdala-OFC connectivity
the unique variance associated with CU traits is related to ___
decreased amygdala activity
the unique variance associated with conduct problems is associated with ___
increased amygdala activity to affective theory of mind scenarios
in response to empathy-inducing film clips portraying sadness, anger, or happiness, people with high CU had…
less heart rate change from baseline, but no diff in resting HR or facial affect
in response to emotional pictures, people with high CU and high anxiety had ___
greater heart rate deceleration; sensitivity to negative stimuli
CD+CU tend to show blunted and attenuated ___ because of ___
autonomic reactivity, long allele for 5HTTLPR
dysfunctional parenting associated with ___ but not ___
CD-CU problems
not CD+CU problems
coercive parenting predicted greater conduct problems in ___
low CU groups
parental warmth predicted fewer CP in ___, but not ___
high and medium CU groups
not low CU group
autonomic differences or similarities in CD vs. CD+CU
CD: low resting HR, low electrodermal response
CD+CU: low resting HR, low electrodermal response
neural differences in CD vs. CD+CU
CD: decreased frontal activity, increased amygdala
CD+CU: decreased amygdala, poor connectivity
genetic differences/similarities in CD vs. CD+CU (3)
CD: low MAOA, homozygous short 5HTTLPR, COMT val/met
CD+CU: high MAOA, l/l 5HTTLPR, COMT val/met
expressive differences in CD vs. CD+CU
CD: reactive, impulsive
CD+CU: cold/unemotional, proactive
early patterns of coercive parent-child relations are thought to result from…
reciprocal influences between harsh parenting and dysregulated affect in overaroused children
5 parts of parental warmth
- positive parenting
- positive feedback
- engagement
- monitoring
- attachment
parenting: ___ as opposed to ___ is more important for socialization of under-aroused children
affective quality of parent child relationship
vs discipline
parenting: high CU children may be particular susceptible to influence of ___ for development of (2)
parental warmth
empathic concern/emotional responding; internalization of parental moral and rule-based values
COMT met/val variant results in ___, which increases risk of (4)
reduces dopamine PFC modulation
- conduct problems
- aggression
- criminal behavior
- CU traits
antisocial children have decreased ACC during processing of (4)
- negative pictures
- attention
- emotional words
- non-rewarded and rewarded tasks
antisocial children have ___ OFC reactivity during (2)
reduced
- decision making tasks
- rewarded continuous performance tasks
antisocial children have ___ activation in caudate when previously rewarded behavior is ___
increased
no longer rewarded