EXAM 2 Flashcards
first line tx for persons without cognitive impairments who present with urge incontinence:
pelvic floor muscle exercises
bladder retraining
Pharmacological therapy with _______ is an option for tx urge incontinence if behavioral therapy is unsuccessful; b/c of adverse effects, these agents are not recommended in _____
______
anticholingergics
older adults
most common types of urge incontinence in women:
urge, stress and mixed
less common: overflow and functional
overflow incontinence is often caused by adverse effects of ________ drugs or by _____ ______ innervation from neurologic dx
anticholinergic
impaired detrusor
what kind of UI?
s/s: loss of urine accompanied or preceded by strong desire to void; may be accompanied by frequency and nocturia
- most common is older adults with a strong association with stroke
urge incontinence
what kind of UI?
s/s: loss of urine with physical exertion or increases in intr- abdominal pressure ( sneezing, coughing, laughing)
- most common in younger women, second more common type in older adults
stress incontinence
conservative mgmt of urge incontinence:
weight loss; fluid reduction; constipation management; bladder training; pelvic floor muscle exercises; electrical stimulation of the posterior tibial nerve
pharmacological mgmt of urge incontinence:
anticholinergic drugs
beta adrenergic agonists
botox
intravaginal estrogen
surgical mgmt of urge incontinence:
neuromodulation ( implanted sacral nerve stimulation)
conservative mgmt of stress incontinence:
weight loss, smoking cessation, fluid reduction, constipation mgmt, pelvic floor muscle exercises, extracorporeal magnetic innervation, electrical stimulation, mechanical devices ( pessary, urethral plugs)
pharmacologic stress incon. mgmt:
alpha adrenergic agonists
cymbalta
surgical mgmt of stress incontinence:
sling procedures
(suburethral sling with tension free vaginal tape, pubovaginal sling, midurethral sling)
urethropexy
periurthral injections of bulking agents
natural menopause occurs around ___ years old
52
premature menopause describes menopause before age ___
40
metorrhagia
irregular cycles with heavy, prolonged flow
oligomenorrhea
long cycles with scant flow
polymenorrhea
short cycles with regular flow
diff dx for dysfunctional uterine bleeding in non - pregnant women
trauma: blunt force, penetrating force, foreign bodies
infectious: vaginitis, cervicitis, endometritis
DUB: ovulatory, anovulatory, andenomyosis
benign growths:
uterine leiomyomas, cervical polyps
malignancy: vulvar, cervical, uterine, ovarian,
systemic dx: weight loss, stress, excessive exercise, hypothyroid, hyperthyroid, hyperprolactinemia, liver failure, renal failure
medications: anticoags, antipsychotics, corticosteroids, tamoxifen, SSRI’s, metformin
contraceptives
adenomyosis
endometrial tissue, which normally lines the uterus, exists within and grows into the muscular wall of the uterus. The displaced endometrial tissue continues to act as it normally would — thickening, breaking down and bleeding — during each menstrual cycle. An enlarged uterus and painful, heavy periods can result.
Dysfunctional uterine bleeding diagnostics, start with:
pregnancy test & CBC
inspect perineum, speculum exam including pap smear and cervical cultures,
bimanual exam
rectal exam
if H&P don’t point toward medical or infectious cause, source of bleeding not identified:
US and gyn consult
structural causes of AUB:
polyp
adenomyosis
leiomyomas
malignancy and hyperplasia
non structural causes of AUB:
coagulopathy
ovulation dysfunction
endometrial
iatrogenic
types of fibroids
submucosal: under the lining of the womb, can grow on stalk ( pedunculated)
intramural: within the wall of the womb, most common type, may distort the uterine cavity or cause irregular external uterine contour
subserosal: on the outer wall of the uterus and usually causes no s/s till it grows large enough to cause interference to adjacent organs, sometimes they have stalk.
failure to menstruate by age 14 w/out sex characteristics or 16 with sex characteristics is:
amenorrhea
secondary amenorrhea: pregnancy is #1 reason
lack of menstrual cycles for 3 or more months in a female who has achieved menarche
evaluation of amenorrhea:
Urine HCG - #1
CMP, TSH, FSH, LH, prolactin
testosterone, DHES for androgen excess ( look for associated physical changes)
progesterone challenge to eval for outflow integrity and pituitary gonadal function( if bleeding occurs, consider an ovulation as cause, if no bleeding, consider low estrogen)
amenorrhea tx:
if progesterone challenge neg: oral estrogen /progesterone
if challenge pos: adequate estrogen - administer progesterone for 10 days each month to prompt cycle
consult with GYN/endocrinology
eval for menorrhagia:
CBC including platelets coags ( PT/INR, PTT and LFTS) TSH transvaginal ultrasound for fibroids endometrial biopsy especially is > 35 or risk for hyperplasia, PCOS, endometriosis, adenomyosis
UA results: heavy proteinuria and lipiduria indicate?
nephrotic syndrome
UA results: hematuria with dysmorphic RBC’s, RBC casts and proteinuria is indicative of?
glomerulonephritis
UA: pigemented granular casts ( muddy brown casts) and renal tubular epithelial cells alone or in casts suggest?
acute tubular necrosis
UA with WBC’s ( including neutrophils and eosinophils) ,WBC casts, RBC’s and small amounts of protein suggest?
interstitial nephritis and pyelonephritis.
proteinuria is excessive protein in excretion in the urine, greater than _______ mg/24h in adults
150-160
proteinuria of more than 1g/day=
less than 1g/day=
glomerular in origin
multiple causes along nephron segment
functional proteinuria: benign process stemming from stressors such as:
acute illness, exercise, “orthostatic proteinuria”
overload proteinuria causes:
results from overproduction of circulating, filtrable plasma proteins or myoglobinuria in rhabdomyolysis OR hemoglobinuria in hemolysis
glomerular proteinuria is seen in:
diabetic nephropathy
increased permeability of albumin across a damaged GBM
results from effacement of epithelial cell foot processes and altered glomerular permeability with an increased filtration fraction of normal plasma proteins
tubular proteinuria causes:
acute tubular necrosis, toxic injury, drug induced interstitial nephritis, hereditary metabolic disorders
results from faulty reabsorption of normally filtered proteins in the proximal tubule
hematuria is significant if:
there are more than three red cells pre high power field on at least two occasions
most common extraglomerular sources of hematuria:
cysts, calculi, interstitial nephritis and renal neoplasia
glomerular causes of hematuria:
IgA nephropathy, thin GBM dx, membranoproliferative glomerulonephritis, systemic nephritic syndromes, hereditary glomerular dx
The GFR measures the ____________ ultra filtered across the glomerular capillaries and correlates with the ability of the kidneys to ________
amount of plasma
filter fluids and various substances
GFR in normal individuals is usually:
100-120
unexplained acute kidney injury or CKD, acute nephritic syndromes, unexplained proteinuria and hematruria, previously identified and treated lesions, SLE and other systemic dx associated with kidney dysfunction, suspected transplant rejection all indicate need for:
percutaneous needle biopsy
essential of dx of acute kidney injury:
rapid increase in serum creatinine
oliguria can be associated
s/s depend on cause: pre renal, intrarenal, post renal
pts with acute kidney injury of any type are at a _______ for all cause mortality, whether or not there is _______
higher risk
substantial renal recovery
essential of dx of acute tubular necrosis
acute kidney injury
ischemic or toxic insult with underlying sepsis
urine sediment with pigmented granular casts and renal tubular epithelial cells is pathognomic but not essential
prerenal causes are the most common of acute kidney injury, and due to:
renal hypoperfusion
decreased renal perfusion can be caused by:
a decrease in intravascular volume, a change in vascular resistance, low cardiac output
causes of volume depletion leading to decreased renal perfusion:
hemorrhage, GI losses, dehydration, excessive diuresis, extravascular space sequestration, pancreatitis, burns, trauma, peritonitis
changes in vascular resistance leading to decreased renal perfusion:
sepsis, anaphylaxis, anesthesia, after load reducing drugs, renal artery stenosis
low cardiac output is a state of ______ renal arterial blood flow. this occurs in states of:
low effective
cardiogenic shock
heart failure,
pulmonary embolism, pericardial tamponade, arrhythmias, valvular disorders
BPH is the _______ of the prostate ( not associate with or a precursor to cancer) that can lead to ________, likely as the result of an enlargement in _______ and an increase in the number of __________
enlargement
bladder outlet obstruction
prostatic connective tissue
epithelial and smooth muscle cells
In BPH, bladder detrusor ____ occurs as a result of difficulty emptying bladder with increased bladder outflow obstruction
hypertrophy
chronic incomplete bladder emptying causes _____ and predisposes to _______ and _____ with secondary inflammatory changes including ______
stasis
calculus formation and infection
prostatitis and UTI
DX of BPH:
digital rectal exam : prostate is enlarged, rubbery and has lost median sulcus
UA to rule out infection/other dx
postvoid residual test, transracial ultrasound, prostate biopsy
a systematic eval for ________ must be done on any man who has an abnormal prostate exam with or without urinary s/s
prostate cancer
BPH s/s:
increased frequency of urination, decreased force of stream, nocturia, sensation of incomplete emptying, urinary urgency, hesitancy, a need to strain or push to initiate or maintain urination to more fully empty the bladder
drugs with _______effect can cause acute urinary retention in men with BPH, as can _____ and _____
anticholinergic ( tricyclic antidepressants, antihistamines)
opioid use and inactivity
caffeine, alcohol and artificial sweeteners are all ______ that can worsen _________
bladder irritants
urinary frequency