Exam 2 Flashcards
How do osteoblasts become osteocytes?
Other osteoblasts start to build bone over them and they get stuck in the matrix of the bone
What are concentric rings?
They are compact bone being formed around blood vessels that have osteocytes in trapped between their layers
What is spongy/trabecular bone?
Less dense bone that does not aid with support against forces. This type of bone is usually broken down for calcium when the body has low levels. It also has osteoblasts cells all over its outer layer
What are chondrocytes?
Cartilage cells that formed from random tissue being compacted together
How does a cavity in the bone form?
Chondrocytes starts to undergo program death and form a cavity. Blood vessels then enter cavity and bring osteoclast and osteoblasts cells with them.
What is the epiphysis growth plate composed of?
Chondrocytes
What is the difference between epiphysis and diaphysis?
Epiphysis is the ends of the bone and diaphysis is the shaft of the bone
Where is the second ossification center located?
In epiphysis
What is the metaphysis?
It is the site where developing long bone occurs, mechanism for bone getting longer
How does cartilage turn into bone?
- Reserve bone: where Chondrocytes are resting
- Chondrocytes starts to divide rapidly
- Cells hypertrophy (grow)
- Cells are calcified in growth plate
- Cells then enter metaphysis where they encounter blood vessels and ossification/mineralization occurs (turn into bone)
In what fashion is bone built?
Born is built towards the center and then osteoclast and osteoblasts shape the bone in the metaphysis to make it longer
What causes growth plates to disappear?
Hormone slows that causes the division of Chondrocytes to slow, meanwhile osteoblast is converting all Chondrocytes into bone faster than Chondrocytes are dividing.
How does bone get longer?
Read portion from outside and building it inside in upward direction of the metaphysis
Where is the youngest and oldest part of the bone located?
Metaphysis outer layer is the youngest.
Middle of the shaft is the oldest.
Growth stages of bone
- Cartilage on outside
- Periosteum layer would start to form
- Cartilage cells would hypertrophy and ossification would begin
- Primary and second ossification centers form
- Growth plates form
- Growth plates disappear
Ossification in newborns
Ossification gets going during week of embryo and then week after birth ossification quickly speeds up to form metacarpals and skull
What is the outside layer of the bone called?
Periosteum
When does the primary ossification center appear?
During gustation in the diaphysis
When do the secondary ossification centers appear?
Appear after birth in epiphysis
When do growth plates disappear in long bone?
Late adolescence or earl adulthood (not all bones are the same) arms can still be growing when legs stopped
White fat tissue
Thy are not thermogenic. Contributes to internal and subcutaneous fat and has important metabolic functions. Produces hormone derivatives
What is leptin?
Helps regulate entry to puberty and is produced by adipocytes
How do adipocytes grow?
First few years, they increase in diameter by hypertrophy. As we get older adipocyte cells start to divide through hyperplasia.
What is fat mass?
All sources of adipose tissue (fat). This fat is found underneath skin and around organs
Due to F=ma. As fat mass increases acceleration decreases
What is fat free mass?
All organs, blood, and water (everything but fat). This correlates with the body’s ability to produce force
How does MUSCLE grow? ( not adipocytes)
First year, hyperplasia and thoughout life it then grows in diameter through hypertrophy (opposite from adipocytes)
How does estrogen effect fat mass?
Estrogen encourages fat deposition therefore increases fat mass. That’s why females tend to have higher fat mass than males. Testosterone has opposite effect ( burns fat)
Trend of percent fat overtime
High when first born (Hugh subcutaneous levels when baby, hence fat babies). It then decreases during childhood because we are gaining fat free mass faster than fat mass). During puberty girls increases due to estrogen and males increase with girls until puberty two years later where it decreases due to testosterone
Trend of fat and fat free mass
Fat mass increases throughout childhood and plateaus in boys during puberty. Fat free mass increases throughout childhood and plateaus in females
Vein appearances in babies compared to children
Subcutaneous fat high in babies hard to find veins.
Subcutaneous drops dramatically through childhood and veins are easier to find
HOW DOES INTERNAL FAT GROW THROUGHOUT LIFE?
IT STEADILY INCREASES THROUGHOUT LIFE
How long is normal human gustation?
40 weeks
What is hyaline membrane disease?
Lungs cannot inflate by themselves due to prematurity because they lack surfactant
What are the 3 different zones of the lung?
Conductive: conduct gas to and from the lung (arteries, veins, airways)
Respiratory: where gas exchange occurs (alveoli)
Transitional: oxygen and co2 end up in the capillaries (capillaries)
How many times does bronchi branch before reaching respiratory zone?
- And then 7 more times within respiratory zone
What is the purpose of bronchi?
They keep junk out of our lungs, covered in cilia that beat up bacteria. Meant to keep lungs clean
RESPIRATORY MEMBRANE NEEDS TO BE WHAT FOR OXYGEN TO REACH BLOOD CELLS?
EXTREMELY THIN!
What are type II cells?
They have lamellar bodies that secrete surfactant
When does the lung start to develop alveoli?
36 weeks. Before these are formed viable decreases
What are the four stages of lung development?
- Embryonic
- Pseudo glandular
- Canicular
- Saccular
What occurs in the embryonic stage?
Start to form the first and second generation of bronchi, larynx forms, mesenchyme tissue surround airways
What occurs in the pseudo glandular stage?
Finish forming transitional zone. has glandular appearance and lung is expanding in size. Has loose mesenchyme cells growing around bronchi. BABIES ARE UNVIABLE UNTIL CAPILLARIES ARE FORMED
What occurs in the canalicular stage?
Mesenchyme cells will start to give rise to capillaries. For the first time have a structure that holds airs. AT THE END OF THIS STAGE BABIES ARE POSSIBLY VIABLE
When do babies become viable?
After canicular stage when capillaries have formed
What occurs in the saccular stage?
Capillaries are forming still but at not close to each other yet, they are starting to migrate to epithelial membrane, so oxygen can be diffused.
ALVEOLI STILL HAVE NOT FORMED
How are alveoli formed?
Budding new septum from capillaries. Between each alveolus there are two layers of capillaries that result from septa.
How do capillaries increase oxygen diffusion rate?
The interstitial fluid between two capillaries will cause them to fuse and create on capillary that is capable of diffusing oxygen through all sides.
What are the 4 challenges premature babies face?
- Poor alveolar growth and thick membrane
- Poor surfactant production
- Poor respiratory control and responsiveness
- High pulmonary resistance
What are the 3 factors that diffusion depends on?
Concentration
Distance
Cross-sectional area
In premature babies we can only increase the concentration of air
What is the function of surfactant?
Since water is very polar and bonds to itself it has a high tension. Water causes tension on alveoli and they collapse when surfactant is not available. It reduces liquid tension between the two
Alveologenesis
Thinning of the interstitial layers by apoptosis so that two capillaries merge into one. Cells also differentiate to produce surfactant
What causes bronchi pulmonary dysplasia
Only occurs in premature babies due to a disruption in alveoli growth mechanical ventilation and supplemental oxygen
Risks of BPD
Mortality decreases with maturity between canalicular and saccular stage. Remember that babies are unviable before canalicular stage
Results of BPD
Hypoxemia (low concentrations of oxygen in the blood), difficulties eating, increase risk of respiratory infections, asthma
How are chemoreceptors different in premature babies?
Their development is suppressed and therefore cannot sense changes in arterial oxygen.
Premature babies breathing patterns
Have periodic apneas that result in arterial oxygen desaturation that effect brain development. Brain isn’t signaling breathing correctly. Will eventually grow out of it with no supplemental oxygen. High risk of dying from SIDS
Why can premature babies not travel to different altitudes?
Their chemoreceptors cannot sense the different oxygen levels and they will not be able to change breathing patterns. Supplemental oxygen also prevents chemoreceptors from fully developing
What is congenital diaphragmatic hernia
Malformation of the diaphragm hat allows the organs of the abdomen to move into the chest. This results from mesenchyme tissue not explaining in pseudo glandular stage and prevents lung from growing fully