exam 2 Flashcards by Kate McDonald

Q

cephalosporins

A

ICWS

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Q

penicillins

A

ICWS

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Q

monobactams

A

ICWS

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Q

carapenems

A

ICWS

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Q

vancomycin

A

ICWS

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Q

fosfomycin

A

ICWS

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Q

bacitracin

A

ICWS

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Q

aminoglycosides

A

30s inhibitor

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Q

tetracycline

A

30S inhibitor

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Q

glycylcyclines

A

30S inhibitor

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Q

macrolides

A

50S inhibitor

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Q

ketolides

A

50S inhibitor

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Q

streptogramin

A

50S inhibitor

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Q

oxazolidinones

A

50S synthesis

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Q

“broad spectrum”

A

50s inhibitors

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Q

fluoroquinolones

A

DNA gyrase

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Q

metronidazole

A

DNA fragmentation

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Q

nitrofurantoin and methenamine

A

DNA damage

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Q

sulfonamide

A

folic acid metabolism

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Q

daptomycin

A

binds to membrane and depolarizes it

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Q

mupirocin

A

binds to tRNA synthase

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Q

polypeptide antibiotics

A

binds to G- cell membrane phospholipids

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Q

isoniazid

A

inhibits synthesis of mycolic acid

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Q

rifampin

A

inhibits DNA dependent RNA polymerase

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Q

ethambutol

A

inhibits arabinosyl transferase

Q

pyrazinamide

A

unknown mechanism

Q

streptomycin

A

30S inhibitor

Q

Dapsone

A

interferes w/ folic acid metabolism

Q

amphotericin B

A

cell wall inhibitor

Q

Azoles

A

cell wall inhibitor

Q

echinocandins

A

cell wall inhibitors

Q

Flucytosine

A

metabolic antagonism of fungal DNA and RNA

Q

griseofulvin

A

binds microtubules

Q

terbinafine

A

interferes w/ sterol biosynthesis

Q

oral penicillinase resistant penicillins

A

Dicloxacillin

Oxacillin

Q

oral 1st gen cephalosporin

A

cephalexin

Q

oral 2nd gen cephalosporins

A

ceflacor

cefprozil

Q

oral 3rd gen cephalosporins

A

cefixime

Q

drug w/ MAOI side effects

A

linezolid

Q

monobactam spectrum

A

aerobic G- rods

Q

carapenem spectrum

A

G+, G-, aerobes, anaerobes

Q

aminoglycoside spectrum

A

aerobic G- enteric rods

Q

tetracycline spectrum

A

G+, G-, anaerobes, aerobes, atypicals

Q

macrolide spectrum

A

G+

Q

ketolide spectrum

A

broad

Q

fluoroquinolone spectrum

A

aerobic G- rods w/ G+ coverage as well

Q

polypeptide antibiotic spectrum

A

G-

Q

mupirocin spectrum

A

G+, some G-

Q

cephalosporin toxicity risk

A

nephrotoxicity

Q

carapenem risk

A

imipenem and cilstatin- seizure risk

Q

vancomycin toxicities

A

ototoxicity

nephrotoxicity

Q

bacitracin toxicity

A

parenteral- nephrotoxicity

Q

fluoroquinolone toxicities

A

increased QT interval

cartilage issues

Q

sulfonamide toxicities

A

SJS

kernicterus- not for infants

Q

polypeptide antibiotic toxicity

A

nephrotoxic, use only topically

Q

cephalosporins w/ CNS penetration

A

Ceftriaxone

Cefotaxamine sodium

Q

tx for osteomyelitis

A

clindamycin

Q

only drug w/ 100% CNS penetration

A

Chloramphenicol

Q

the only bacteriocidal protein synthesis inhibitor

A

aminoglycoside

Q

which drugs interfere with the P450 system?

A

erythromycin
rifampin
ketoconazole

Q

drugs that elevate liver enzymes

A

caspofungin

flucytosine

Q

antifungals w/ CSF penetration

A

fluconazole

flucytosine