Exam 2 Flashcards
Heart Failure
Inability of the heart to pump sufficient blood to meet the demand of the body
Signs of Heart Failure
Exercise intolerance, very fatigued with activity, most cases are related to MI damage and chronic HTN
Clinical Manifestations of Heart Failure
Fatigue, Dyspnea, Orthopnea, PND, Tachycardia, Edema, Nocturia, Behavioral changes, chest pain, weight cahnges
Classifying Left Ventricular Failure
Left ventricle has weak pump, backs up into the left atrium and into the lungs
Causes: HTN, CAD, Vascular Disease
Classifying Right Ventricular Failure
Right ventricle weak, unable to pump into the lungs, symptoms come from back up into the systemic system, edema!
Causes: LV Failure, RV infarct, Pulmonary HTN
Bi-Ventricular Failure
Usually RV secondary to LV failure
Acute vs Chronic Failure
Acute= immediate, usually LV, following acute MI Chronic= Long term, less immediate
Systolic vs Diastolic Failure
Systolic = Reduced ejection fraction Diastolic= decreased filling
Low output vs High Output Failure
Low= Reduced pumping, more common High= fever, hyperthyroidism, pregnancy
Compensatory mechanisms for Heart Failure
Increased HR and Increased SV (to maintain output)
Arterial vasoconstriction (to increase perfusion and BP)
Sodium and H2O retention (non-therapeutic)
Myocardial hypertrophy
Diagnosing Heart Failure
CXR= show cardiomegaly, fluid in lungs ECHO= EJ calculation Angiography= visualize heart PA Catheter= Evaluate pressure EKG= conduction abnormalities
B-type natriuretic peptide (BNP)
Plasma levels may correspond to the severity of underlying cardiac dysfunction, provides prognostic information, elevated plasma BNP indicates a high risk of morbidity and mortality in patients with chronic heart failure or acute coronary syndrome. Should be <100.
Functional Classifications of Heart Failure
Class 1=No limitation
Class 2= Slight limitation
Class 3= More severe
Class 4= Inability to carry on any activity
ACE Inhibitors
Reduce workload of heart, increase renal function
Diuretics
Pulling off fluid, many will also have K+ replacements
Beta Blockers
Overall longevity, make the heart work less
Aldactone
Potassium sparing diuretic
Digoxin
No longer top drug, lowers work of the heart, can have toxic levels and nasty side effects
Nitrates
Dilate blood vessels
Rational Polypharmacy
Balancing beneficial and adverse drug effects and monitoring how such drug regimens affect each patient with heart failure
Focus of Heart Failure Therapy
Improve survival, relieve symptoms
Clinical Manifestations of Acute LV heart failure
Respiratory distress; crackles, increased HR, S3 gallop rhythm, restlessness
Pulmonary Edema
Life threatening LV failure; given IV diuretics, MSO4, NTG, Nitroprusside (dilates blood vessels), position in high fowlers, oxygen, and foley catheter
Rheumatic Carditis
Affects 40% of patients with RF, group A beta-hemolytic streptococci (basic strep throat), Impairs pumping function, muscle tissue, pericardium, and valves.
basically Inflammation of cardiac valves related to strep throat
Valvular Heart Disease
Congenital or acquired dysfunctions, valvular stenosis, insufficiency or regurg
Mitral Stenosis
Usually from rheumatic carditis, valve is thickened by fibrosis and calcification. Sx: Dyspnea with exertion, fatigue, orthopnea, neck vein distention
PE: diastolic murmur
Mitral Regurgitation
Caused by RHD, LA and LV dilate and hypertrophy, may be symptom free for decades; common complaints are anxiety, chest pain, and palpitations. Other Sx include fatigue, weakness, and dyspnea, and orthopnea
PE: holosystolic murmur
Mitral Valve Prolapse
Valvular leaflets enlarge and prolapse into the LA during systole, usually benign and asymptomatic
PE: Systolic Click
Familial occurence usually, associated with marfans syndrome- cardiac disease, visual problems, very long arm span, most common in young to middle aged thin women
Aortic Stenosis
Increased resistance to ejection during systole, leading to LV failure and eventually RV failure. Sx: dyspnea, angina, syncope. PE= systolic murmur
Most common in aging populations, majority men
Aortic Regurgitation
Creates dilation of LV, asymptomatic for many years untilc LV failure occurs, usually from non-RHD: endocarditis, congentital, HTN, marfans syndrome, men Sx: DOE, orthopnea, PND
PE= Diastolic Murmur - second intercostal space on right side
Cardiomyopathy
Enlarged cardiac muscle, decreased pumping, irreversible, often unknown etiology, could be etoh,
Dilated Cardiomyopathy
Damage myofibrils, decreased CO
Sx: fatigue, DOE, gallop rhythms
More common in men of middle age
Hypertrophic Cardiomyopathy
LVH with obstruction in LV outflow, abnormal stiffness of LV, genetic usually, often cause of sudden death in young athletes, gallop rhythms, a.fib
Restrictive Cardiomyopathy
Rarest, LV filling is restricted, Sx: dyspnea, fatigue, right sided HF, gallop rhythms
Infective Endocarditis
Infection of valves and endothelial surface of heart cause by direct invasion of bacteria, usually r/t valve replacements, structural cardiac defects, or IV drug abuse. Sources: Oral cavity, skin lesions, infections, invasive procedures.
Patient with the following should receive antibiotics before dental procedures
Prosthetic cardiac valves
Previous bacterial endocarditis
Certain congenital cardiac malformations
Cardiac transplantation
The following no longer require antibiotics prophylaxis
Rheumatic Valve Dysfunction Mitral valve prolapse Previous CABG Heart Murmurs Cardiac Pacemakers and defibs
Infective Endocarditis 2
pt c/o chills, fever, flu like symptoms PE=new onset of murmur Oslers nodes and Janeways lesions petechiae Splinter hemorrhages arterial embolic complications
CO: SV X HR
4-6L/min is normal
HR
60-100 beats/min is normal
SV
73ml/contraction is normal
Preload
5-12 mmHg is normal
Cancer is…
The second leading cause of death in the US. Cancer accounts for nearly one-quarter of all deaths in the US.
Highest Estimated new cases in males and females
Prostate for males
Breast for females
Second for both is lung and bronchus
Highest estimated deaths related to cancer
Lung and bronchus cause the most deaths, followed by prostate and breast
Cancer disparity between african americans and whites
African americans are 10% -20% less likely to survive cancer, this is due to less likely to recieve cancer diagnosis at and early stage, unequal access to medical care, and tumor characteristics not related to early detection
Individual Actions to Prevent Cancer
- Maintain healthy weight
- Physical Activity
- Consume healthy diet with plants
- Limit alcohol consumption
- Stop smoking
- Limit sun exposure
- Protect yourself from toxic substances
CAUTION
Change in bowel/bladder habits A sore Unusual bleeding/discharge Thickening/Lump Indigestion or swallowing issues Obvious change in wart or mole Nagging cough/hoarseness
Unmodifiable Risk Factors for Cancer
Family history, Age, Gender, Impaired immunity
Prognostic Factors for Cancer
Performance status: Karnofsky Scale, ECOG Scale, Staging: TMN Classification, Grading