Exam 2

Question 1

list 4 causes of chronic inflammation

Answer 1

1/ persistent infections by microorganisms (mycobacterius, some viruses, fungi and parasites)

2. immune-mediated inflammatory diseases
3. autoimmune diseases
4. atherosclerosis

Question 2

list 4 hallmarks of chronic inflammation

Answer 2

1. infiltration of mononuclear cells (M0, lymphocytes and plasma cells)
2. tissue destruction
3. proliferation of small blood vessels
4. fibrosis

Question 3

list the names of the following tissue macrophages

1. liver
2. spleen
3. lymph nodes
4. lungs
5. CNS

Answer 3

1. liver - kupffer
2. spleen
3. lymph nodes - sinus histiocytes
4. lungs - alveolar
5. CNS - microglia

Question 4

where do mononuclear phagocytes arise from?

what is the half-life of blood monocytes? what about tissue macrophages?

Answer 4

a common precursor in the bone marrow

• blood monocytes - about a day
• tissue macrophages - several months to years

Question 5

when would you find monocytes as the predominant WBC at an inflammation site?

Answer 5

within 48 hours (neutrophils would be predominant the first 48 hours)