Exam 2 Flashcards

1
Q

Agonists versus antagonists?

A

Agonist: mimics or enhances the effects of a neurotransmitter by having the same effect on the receptor as the neurotransmitter, by increasing the transmitters effect on th receptor, or by blocking the reuptake or the degration of the transmitter.

Antagonist: May occupy the receptors without activating them, simutaneously blocking the transmitter from binding to the receptors or it may decrease the availability of th neurotransimitter for instance, by reducing its production or relase from the presynaptic terminals.

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2
Q

What are the different treatment strategies?

A

agonist treatment: Addiction treatment that replaces the addicting drug with another drug that has a similar effect.

antagonists treatment: A form of treatment for drug addiction using drugs that block the effects of the addicting drug.

Aversive treatments: Cause a negative reaction when person takes the drug.

Antidrug vaccines: Molecules attach to drug and stimulate immune response to
create antibodies that degrade drug

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3
Q

What are psychoactive drugs?

A

Psychoactive drugs are those that have psychological effects, such as anxiety relief or hallucinations

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4
Q

How do Opiates work?

A

Any drug derived from the opium poppy. The term is also used to refer to effects at opiate receptors, including those by endorphins.

Effects include: analgesic (removing pain), hypnotic (inducing sleep), and euphoric (creating a sense of happiness or ecstasy)
Examples:
 Morphine
 Codeine
 Heroin; synthesized from morphine
 Oxycontin
Examples in fiction:
 Wizard of Oz, field of poppies
 Game of Thrones, “milk of the
poppy”
 Hunger Games, “morphling

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5
Q

How do Depressants work?

A

A drug that reduces central nervous system activity. The group includes sedative (calming), anxiolytic (anxiety reducing), and hyponotic substances.

Alcohol is the most common and abused in this class.
Example:
 Alcohol
 Barbituates
 Benzodiazepines

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6
Q

How do Stimulants work?

A

A drug that activates the nervous system to produce arousal, increased alertness, and elevated mood. Wide range of drugs from legal (caffeine) to illegal (cocaine), which vary in the degree of risk they pose.
Examples:
 Cocaine
 Amphetamines
 Nicotine
 Caffeine

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7
Q

How do Psychedelics work?

A

Any compound that causes perceptual distortions in the user. Often referred to as hallucinogenic, they are most noted for leading to perceptual distortions: Light, color, and details are intensified; Objects may change shape, sounds may evoke visual experiences, and light may produce auditory sensations.
Examples:
 LSD
 Mushrooms/psilocin, psilocybin
 Mescaline/peyote
 Phenylcyclohexyl piperidine (PCP)/angel dust
 Methylenedioxymethamphetamine (MDMA)/ecstasy

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8
Q

Explain GABAA receptor complex

A

GABA is the most prevalent inhibitory neurotransmitter in the brain. Alcohol specifiicaly affects the A subtype of GABA receptors. Because GABA A receptors is important in the action of other drugs, we are giving it special attention. It is actually a receptor complex, composed of five different kinds of receptor sites. Two of the receptors respond to GABA. Their activation opens the receptor’s chloride channels and the influx of chloride ions hyperpolarizes the neurons. Other receptors in the complex respond to alcohol, to steroids, to barbiturates, and to benzodiazepines; these drugs enhance the binding of GABA to its receptor and thus its ability to open the chloride channel. This is why its so dangerous to mix alcohol with barbiturates or benzodiazepines.

receptor complex
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9
Q

What are effects of heavy marijuana use on the brain and mental function?

A

Long-term heavy users have various brain anomalies, including reduced volume in the hippocampus and amygdala as well as impaired white matter connectivity in the hippocampus and corpus callosum.
In a study, individuals who used mariguana from their teens to age 38 lost an average of 6 IQ points. Abstinence did not lead to recovery possibly due to long usage.

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10
Q

Explain Mesocorticolimbic dopamine system and affiliated brain areas

A

Consists of the ventral tegmental area and the brain regions receiving its dopaminergic projections, including the nucleus accumbens, the prefrontal cortex, the amygdala, and the hippocampus.
All addictive drugs target the mesolimbic system and increase dopaminergic activity in the nucleus accumbens. Dopaminergic inputs to the nucleus accumbens are also activated by natural reinforcers, such as food, water, and sexual activity.

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11
Q

How do we define instincts?

A

a complex behavior that is automatic, unlearned, and unmodifiable and occurs in all the members of a species.
e.g., migration in birds or parental behaviors found in most animals.

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12
Q

What is homeostasis?

A

An particular system is in balance or equilibrum.
or
A body system seeks and maintains this condition of balance or equilibrium and has mechanisms to minimize changes to the system.

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13
Q

What are the challenges of an omnivorous diet?

A

Omnivores must distinguish foods that may be nutritious, non-nutritious, or toxic, and we must vary our diet among several sources to meet all our nutritional requirments.

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14
Q

how does an omnivorous diet compare to carnivorous or herbivorous?

A

Omnivorous diet have to seek out several sources of food to meet nutritional requirments meanwhile herbivores can get all the nutrition they need from a single source. Carnivores also have it easy since they achieve a balanced diet from their prey eating a balanced diet.

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15
Q

What are the different taste receptor types? (how they work, and what they help humans do)

A

These five senses are called primaries, that correspond with our dietary needs. The taste sense contributes to dietary selection in three additional ways: sensory-specific satiety, learned taste aversion, and learned taste preference.

  1. Sweet: we readily eat food that is sweet (fruits and carbohydrates)
  2. Salty: salt provides the sodium and chloride ions needed for cellular functioning and neural transmission
  3. Sour: helps distinguish spoiled foods
  4. Bitter: bitter food is likley to be toxic
  5. Umami: aid in our selection of protieins
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16
Q

Explain digestion

A

The breakdown of complex molecules into their components.
Begins in the mouth, leads to the stomach and then the small intestine.
1. Mouth:
* Saliva starts breakdown of starches into glucose
2. Stomach:
* Hydrochloric acid and pepsin mixes with food to digest proteins into amino acids
3. Small Intestine:
* Duodenum: where the rest of digestion takes place
* Fats transformed into fatty acids and glycerol by bile

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17
Q

How does digestion work in the nervous system?

A

There are four particularly important areas in the hypothalamus: the arcuate nucleus (ARC), the lateral hypothalamus (LH), the paraventricular nucleus (PVN), and the ventromedial hypothalamus (VMH).
* ARC is considered the master hypothalamic center for food intake control.
* LH initiates eating and controls several aspects of feeding behavior as well as metabolic responses
* PVN regulates eating and metabolic processes such as body temp., fat storage, and cellular metabolism.
* VMH produces satiety and increases metabolism.

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18
Q

What are hormones and brain regions related to hunger and eating?

A

Ghrelin: an orexigenic peptide hormone that is synthesized in the stomach and relased into the bloodstream during fasting.
Cholecystokinin (CCK): peptide hormone that is released by the stomach and small intestine as food passes into the duodenum. It limits meal size and aids digestion through the release of bile and enzyme.
Peptide YY 3-36 (PYY): a peptide hormone released in the intestines in response to food, which suppresses appetite over a long periods of time.

Fat cells secrete a peptide hormone called leptin that inhibits eating

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19
Q

What is BMI?

A

Body mass index (BMI) is calculated by dividing the person’s weight in kilograms by the squared height in meters. It is a rough measure, and can be inaccurate in some individuals; because muscle is heavier than fat, a healthy, bulked -up athlete will have a higher BMI score.

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20
Q

Obesity: what are biological/genetic causes of weight differences?

A

Heritability
 Obesity: 50-90%
 Basal Metabolism Rate (BMR): the energy required to fuel the brain and other organs and to maintain body temp. Heredity accounts for about 40% of people’s differences in BMR

Genes
 Obesity (ob) on chromosome 6 and Diabetes (db) on chromosome 4 can casue obesity on mice
 FTO gene (A allele): two copies can increase risk of obesity by nearly 70%; even a single copy ups the risk of obesity by 30%. Increases food intake by reducing leptin levels and receptor sensitivity and by increasing ghlerin levels and insulin sensitivity.

Environment: epigenetic

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21
Q

What are associated health outcomes with obesity?

A

Correlated with higher risk of…
 Diabetes (type 2), heart disease, high blood pressure, stroke, colon cancer, reduced lifespan
 Brain changes: reduced temporal lobe, cognitive decline, Alzheimer’s risk
Increased exponentially since 1980 in U.S., global epidemic

22
Q

What are the stages of sexual arousal?

A

There are four stage of sexual response.
1. Excitement phase: Period of arousal and preparation for intercourse (Increased heart rate, respiration rate, blood pressure, and muscle tension)
2. Plateau phase: Increase in sexual arousal levels off. Arousal is maintained at a high level for seconds or minutes, though it is possible to prolong this period
3. Orgasm: Brief, intense experience of pleasure.
4. Resolution: Reminiscent of the period of quiet after return to homeostasis with other drives (muscles relax, blood pressure drops, excitement decreases)

23
Q

What are male/female sex differences?

A
  • Chromosomal makeup (XX for females, XY for males; also XXY XYY, etc for intersex)
  • Reproductive anatomy (testes & penis for males; ovaries & vagina for females)
  • Secondary characteristics post-puberty (facial hair for males; breasts for females; body mass differences)
  • Hormone profiles (differences between males and females for testosterone, estrogen, progesterone)
  • Refractory Periods (present in male sexual response cycle but not present for females)
24
Q

What are brain regions related to sexual activity and response?

A
  • Medial preoptic area (MPOA)
  • Ventromedial Hypothalamus
  • Medial amygdala
  • Paraventricular nucleus (PVN)
  • Sexually dimorphic nucleus (SDN)
25
How is Medial preoptic area (MPOA) related to sexual activity and response?
Involves male and female sexual behavior. * Stimulation in rats (male or female) results in sexual behavior * Opiates (oxycodone, heroin) reduce MPOA, impair sexual behavior
26
How is Ventromedial hypothalamus related to sexual activity and response?
Is important for sexual interest and motivation in both males and females. * Ablation increases female reluctance and reduces male advances
27
how is Medial amygdala related to sexual activity and response?
It contributes to sexual behavior in animals of both sexes. * Active during copulation; stimulation causes DA release in MPOA * Responds to sexually explicit stimuli (e.g., presence of potential sexual partner)
28
How is Paraventricular nucleus (PVN) related to sexual activity and response?
Is responsible for male sexual performance, erection.
29
How is Sexually dimorphic nucleus (SDN) related to sexual activity and response?
Located in the preoptic area. Is three to four times larger in male rats than in females, and a male's level of sexula activity is related to the size of the SDN. * Integrates sensory & hormonal information; coordinates behavioral/physiological responses * Larger size of SDN in males correlated with amount of sexual activity * Size of area dependent on testosterone protection of region during synaptic pruning * Ablation of SDN reduces male sexual activit
30
How is Dopamine related to sexual activity and response?
It creates a reward effect in the nucleus accumbens and has a significant roles in sexual motivation and performance. Stimulation of the medial amygdala releases dopamine in the MPOA, enabling the individual to respond to sexually exciting stimuli. * Dopamine active in ventral tegmental area in males during ejaculation and the nucleus accumbens in females during orgasm * Drugs that increase dopamine levels, such as stimulants and those used in treating Parkinson’s disease, increase sexual activity
31
How is Serotonin related to sexual activity and response?
Is primarily inhibitory to sexual behaviors regardless of sex. * Selective serotonin reuptake inhibitors (SSRIs) increase serotonin at synapses. -- Injecting an SSRI into the MPOA decreases sexual motivation in animals -- Injection into the lateral hypothalamus lengthens the time between copulations and their ability to ejaculate * Serotonin released in the lateral hypothalamus during ejaculation contributes to the refractory period, -- May also cause a drop in dopamine levels which diminishes arousal * SSRIs can interfere with their sexual performance -- Antianxiety drug buspirone, by contrast, decreases the release of serotonin and facilitates orgasms.
32
How is Oxytocin related to sexual activity and response?
It contributes to bonding and causes the smooth muscle contractions involved in male and female orgasm as well as milk ejection during breastfeeding. * Oxytocin increases as males and females masturbate to orgasm * Oxytocin release correlates with the intensity of pleasure
33
Explain sexual dimorphism from embryonic tissue to male versus female sex organs
At the embryonic stage where a seemingly undifferentiated gonad, develops into either a testis (male) or an ovary (female) depending on the presence of the sex-determining genes on the sex chromosomes, ultimately leading to the development of distinct male and female reproductive organs and secondary sexual characteristics * Male  Internal genitalia: Wolffian ducts develop into structures such as epididymis, vas deferens, and seminal vesicles  External genitalia: Testosterone converted to dihydrotestosterone (DHT), promotes penis and scrotum formation * Female  Internal genitalia: Müllerian ducts develop into fallopian tubes, uterus, and upper part of vagina  External genitalia: Absence of high androgen levels = clitoris, labia minora, and labia majora formation
34
What are the three main hormones in control of sexual behavior?
1. Androgen 2. Estrogen 3. Progesterone
35
Androgen hormone levels and their connection to sex-related differences in verbal vs visual-spatial abilities
A class of horomones responsible for male characteristics and functions * testosterone * boys excel in visual spatial abilities compared to girls * transgender men taking testosterone lose verbal ability but improve in spatial performance
36
Estrogen hormone levels and their connection to sex-related differences in verbal vs visual-spatial abilities
A class of horomones responsible for female characteristics and functions * girls excel in verbal abilities compared to boys * males who take estrogens bc they identify as females increase their scores on verbal fluency tasks, but they lose spatial performance
37
Progesterone hormone levels and their connection to sex-related differences.
Hormone produced in males to create testosterone and females to control sexual reproduction
38
what differences are in the physiology of trans- versus cis-gender identity?
The *third interstitial nucleus of the anterior hypothalamus (INAH3)* is larger in men than in women and is thought to be the human counterpart of the SDN. The *central subdivision of the bed nucleus of the stria terminalis (BSTc)* is also larger in males than in females; it is closely connected to the amygdala, hippocampus, and prefrontal cortex. Both have been reported to be cis female sized in MtF transgender individuals. Size in FtM transsexuals was closer to cis-male size.
39
What is Androgen insensitivity syndrome?
A form of 46,XY intersex, is caused by a genetic absence of androgen receptors, which results in insensitivity to androgen. Mullerian inhibiting hormone suppresses development of most female internal organs. Minimal sensitivity to androgens can lead to external genitals that look typically female or typically male or have characteristics of both.
40
Explain Atypical sex chromosomes (e.g., XXY)
Klinefelter syndrome (XXY): A male with an extra X chromosome, often causing reduced testosterone levels, smaller testes, and learning difficulties.
41
Physiology of sexual orientation; the best predictors of homosexuality vs bisexuality
Estimates of homosexuality vary, as do definitions, sampling methods, and individuals’ willingness to accurately report homosexual behavior. Social influence hypothesis: people are more likely to do whatever they see is the “norm”. (In-class we talked about individuals who are bisexual are more likely date individuals of thew opposite sex as opposed to individuals of the same-sex) * Option A: Homosexuality becomes a norm → increased homosexuality (mind & behavior) * Option B: Homosexuality becomes a norm → increased willingness to exhibit behavior (although mental state was always present—with or without norm)
42
What is the James-Lange theory of emotion?
Emotional experience results from the physiological arousal that precedes it, and different emotions are the result of different patterns of arousal. * We feel emotions because we perceive our body’s physiological responses to an event * “We don’t tremble because we are afraid. We are afraid because we tremble.” –William James & Carl Lange, 1884 * Emphasizes role of PNS in generating emotional experience
43
What are mirror neurons?
Neurons that fire both when we enage in a specific act and while observing the same act in others. We mimic other people's gestures, body posture, tone of voice, and facial expressions. This may contribute to empathy and emotional understanding by mirroring observed emotions. It also helps with recognition and interpretation of facial expressions and other nonverbal cues.
44
What brain regions are related to/responsible for emotion?
The Limbic system 1. **Amygdala:** assesses the emotional significance of stimuli; Rapidly evaluates sensory information for its significance to survival or well-being and triggers bodily responses 2. **Prefrontal cortex:** Crucial for conscious emotional experience and deliberate action 3. **Anterior cingulate cortex:** brain structure best known for roles in attention, decision-making, and impulse control. (conscious experience of emotion)
45
What is aggression?
Forceful or assertive behavior that is intended to harm or control another.
46
What are forms/causes of aggression?
* **Predatory aggression:** occurs when an animal attacks and kills prey or a human makes a premeditated, unprovoked attack on another. Cold and emotionless. * **Affective aggression:** aggression characterized by its impulsiveness and emotional arousal * **Proactive or instrumental aggression:** aggression that is unprovoked and emotionless and is intended to bring about gain for the aggressor --->Often (but not exclusively) seen in people diagnosed with psychopathy and antisocial personality disorder * **Reactive or impulsive aggression:** aggression that occurs in response to a threat, real or imagined, characterized by heightened emotionality
47
How does aggression relate to the nervous system.
Aggresion involves interplay of a network of structures. * **Amygdala:** detects and responds to threats * Regions of **prefrontal cortex:** moderates aggression with regard to amygdala * **Hypothalamus:** primary instigator of aggressive behavior * **Insula** (when emotion is involved): recognizing and experiencing emotion --->Dysfunction leads to heightened emotional responses and impulsivity * **Anterior cingulate** (when emotion is involved): emotion regulation, conflict monitoring. ---> Dysfunction leads to poor regulation, emotional dysregulation, aggression
48
What is the role of neurotransmitters and hormones for emotion/aggression
Several hormones & neurotransmitters are related to aggression * **Testosterone:** plays a role in NH animals and both male and female human aggression ---> Significant global effects in the brain and on behavior --->Reduces functional connectivity between orbitofrontal cortex and the amygdala, leading to poor emotion regulation * **Serotonin:** conventionally inhibitory, suppressing motivated behaviors ---> Low serotonin linked to impulsive aggression * **Cortisol:** is also inhibitory to aggression. --->Male prisoners with low cortisol had high levels of calculating and unemotional aggression
49
Anterior cingulate cortex (ACC)
Best known for its role in attention, decision making, and impulse control, also plays a major role in emotion. It is seen to be activated with the anterior insular cortex (AIC) stimultaneously during the experience of emotional feelings. The AIC is considered to be the/a location of emotional awareness; the ACC is believed to use input from the AIC to generate action.
50
What is the physiology of someone with antisocial personality disorder
Can include brain structure abnormalities, neurotransmitter imbalances, and decreased physiological responses to stressful situations. In mice, research suggest that IFN-y co-evolved with social behavior in response to the increasing need for protection against communicable diseases.