Exam 2 Flashcards
Agonists versus antagonists?
Agonist: mimics or enhances the effects of a neurotransmitter by having the same effect on the receptor as the neurotransmitter, by increasing the transmitters effect on th receptor, or by blocking the reuptake or the degration of the transmitter.
Antagonist: May occupy the receptors without activating them, simutaneously blocking the transmitter from binding to the receptors or it may decrease the availability of th neurotransimitter for instance, by reducing its production or relase from the presynaptic terminals.
What are the different treatment strategies?
agonist treatment: Addiction treatment that replaces the addicting drug with another drug that has a similar effect.
antagonists treatment: A form of treatment for drug addiction using drugs that block the effects of the addicting drug.
Aversive treatments: Cause a negative reaction when person takes the drug.
Antidrug vaccines: Molecules attach to drug and stimulate immune response to
create antibodies that degrade drug
What are psychoactive drugs?
Psychoactive drugs are those that have psychological effects, such as anxiety relief or hallucinations
How do Opiates work?
Any drug derived from the opium poppy. The term is also used to refer to effects at opiate receptors, including those by endorphins.
Effects include: analgesic (removing pain), hypnotic (inducing sleep), and euphoric (creating a sense of happiness or ecstasy)
Examples:
Morphine
Codeine
Heroin; synthesized from morphine
Oxycontin
Examples in fiction:
Wizard of Oz, field of poppies
Game of Thrones, “milk of the
poppy”
Hunger Games, “morphling
How do Depressants work?
A drug that reduces central nervous system activity. The group includes sedative (calming), anxiolytic (anxiety reducing), and hyponotic substances.
Alcohol is the most common and abused in this class.
Example:
Alcohol
Barbituates
Benzodiazepines
How do Stimulants work?
A drug that activates the nervous system to produce arousal, increased alertness, and elevated mood. Wide range of drugs from legal (caffeine) to illegal (cocaine), which vary in the degree of risk they pose.
Examples:
Cocaine
Amphetamines
Nicotine
Caffeine
How do Psychedelics work?
Any compound that causes perceptual distortions in the user. Often referred to as hallucinogenic, they are most noted for leading to perceptual distortions: Light, color, and details are intensified; Objects may change shape, sounds may evoke visual experiences, and light may produce auditory sensations.
Examples:
LSD
Mushrooms/psilocin, psilocybin
Mescaline/peyote
Phenylcyclohexyl piperidine (PCP)/angel dust
Methylenedioxymethamphetamine (MDMA)/ecstasy
Explain GABAA receptor complex
GABA is the most prevalent inhibitory neurotransmitter in the brain. Alcohol specifiicaly affects the A subtype of GABA receptors. Because GABA A receptors is important in the action of other drugs, we are giving it special attention. It is actually a receptor complex, composed of five different kinds of receptor sites. Two of the receptors respond to GABA. Their activation opens the receptor’s chloride channels and the influx of chloride ions hyperpolarizes the neurons. Other receptors in the complex respond to alcohol, to steroids, to barbiturates, and to benzodiazepines; these drugs enhance the binding of GABA to its receptor and thus its ability to open the chloride channel. This is why its so dangerous to mix alcohol with barbiturates or benzodiazepines.
What are effects of heavy marijuana use on the brain and mental function?
Long-term heavy users have various brain anomalies, including reduced volume in the hippocampus and amygdala as well as impaired white matter connectivity in the hippocampus and corpus callosum.
In a study, individuals who used mariguana from their teens to age 38 lost an average of 6 IQ points. Abstinence did not lead to recovery possibly due to long usage.
Explain Mesocorticolimbic dopamine system and affiliated brain areas
Consists of the ventral tegmental area and the brain regions receiving its dopaminergic projections, including the nucleus accumbens, the prefrontal cortex, the amygdala, and the hippocampus.
All addictive drugs target the mesolimbic system and increase dopaminergic activity in the nucleus accumbens. Dopaminergic inputs to the nucleus accumbens are also activated by natural reinforcers, such as food, water, and sexual activity.
How do we define instincts?
a complex behavior that is automatic, unlearned, and unmodifiable and occurs in all the members of a species.
e.g., migration in birds or parental behaviors found in most animals.
What is homeostasis?
An particular system is in balance or equilibrum.
or
A body system seeks and maintains this condition of balance or equilibrium and has mechanisms to minimize changes to the system.
What are the challenges of an omnivorous diet?
Omnivores must distinguish foods that may be nutritious, non-nutritious, or toxic, and we must vary our diet among several sources to meet all our nutritional requirments.
how does an omnivorous diet compare to carnivorous or herbivorous?
Omnivorous diet have to seek out several sources of food to meet nutritional requirments meanwhile herbivores can get all the nutrition they need from a single source. Carnivores also have it easy since they achieve a balanced diet from their prey eating a balanced diet.
What are the different taste receptor types? (how they work, and what they help humans do)
These five senses are called primaries, that correspond with our dietary needs. The taste sense contributes to dietary selection in three additional ways: sensory-specific satiety, learned taste aversion, and learned taste preference.
- Sweet: we readily eat food that is sweet (fruits and carbohydrates)
- Salty: salt provides the sodium and chloride ions needed for cellular functioning and neural transmission
- Sour: helps distinguish spoiled foods
- Bitter: bitter food is likley to be toxic
- Umami: aid in our selection of protieins
Explain digestion
The breakdown of complex molecules into their components.
Begins in the mouth, leads to the stomach and then the small intestine.
1. Mouth:
* Saliva starts breakdown of starches into glucose
2. Stomach:
* Hydrochloric acid and pepsin mixes with food to digest proteins into amino acids
3. Small Intestine:
* Duodenum: where the rest of digestion takes place
* Fats transformed into fatty acids and glycerol by bile
How does digestion work in the nervous system?
There are four particularly important areas in the hypothalamus: the arcuate nucleus (ARC), the lateral hypothalamus (LH), the paraventricular nucleus (PVN), and the ventromedial hypothalamus (VMH).
* ARC is considered the master hypothalamic center for food intake control.
* LH initiates eating and controls several aspects of feeding behavior as well as metabolic responses
* PVN regulates eating and metabolic processes such as body temp., fat storage, and cellular metabolism.
* VMH produces satiety and increases metabolism.
What are hormones and brain regions related to hunger and eating?
Ghrelin: an orexigenic peptide hormone that is synthesized in the stomach and relased into the bloodstream during fasting.
Cholecystokinin (CCK): peptide hormone that is released by the stomach and small intestine as food passes into the duodenum. It limits meal size and aids digestion through the release of bile and enzyme.
Peptide YY 3-36 (PYY): a peptide hormone released in the intestines in response to food, which suppresses appetite over a long periods of time.
Fat cells secrete a peptide hormone called leptin that inhibits eating
What is BMI?
Body mass index (BMI) is calculated by dividing the person’s weight in kilograms by the squared height in meters. It is a rough measure, and can be inaccurate in some individuals; because muscle is heavier than fat, a healthy, bulked -up athlete will have a higher BMI score.
Obesity: what are biological/genetic causes of weight differences?
Heritability
Obesity: 50-90%
Basal Metabolism Rate (BMR): the energy required to fuel the brain and other organs and to maintain body temp. Heredity accounts for about 40% of people’s differences in BMR
Genes
Obesity (ob) on chromosome 6 and Diabetes (db) on chromosome 4 can casue obesity on mice
FTO gene (A allele): two copies can increase risk of obesity by nearly 70%; even a single copy ups the risk of obesity by 30%. Increases food intake by reducing leptin levels and receptor sensitivity and by increasing ghlerin levels and insulin sensitivity.
Environment: epigenetic
What are associated health outcomes with obesity?
Correlated with higher risk of…
Diabetes (type 2), heart disease, high blood pressure, stroke, colon cancer, reduced lifespan
Brain changes: reduced temporal lobe, cognitive decline, Alzheimer’s risk
Increased exponentially since 1980 in U.S., global epidemic
What are the stages of sexual arousal?
There are four stage of sexual response.
1. Excitement phase: Period of arousal and preparation for intercourse (Increased heart rate, respiration rate, blood pressure, and muscle tension)
2. Plateau phase: Increase in sexual arousal levels off. Arousal is maintained at a high level for seconds or minutes, though it is possible to prolong this period
3. Orgasm: Brief, intense experience of pleasure.
4. Resolution: Reminiscent of the period of quiet after return to homeostasis with other drives (muscles relax, blood pressure drops, excitement decreases)
What are male/female sex differences?
- Chromosomal makeup (XX for females, XY for males; also XXY XYY, etc for intersex)
- Reproductive anatomy (testes & penis for males; ovaries & vagina for females)
- Secondary characteristics post-puberty (facial hair for males; breasts for females; body mass differences)
- Hormone profiles (differences between males and females for testosterone, estrogen, progesterone)
- Refractory Periods (present in male sexual response cycle but not present for females)
What are brain regions related to sexual activity and response?
- Medial preoptic area (MPOA)
- Ventromedial Hypothalamus
- Medial amygdala
- Paraventricular nucleus (PVN)
- Sexually dimorphic nucleus (SDN)