exam 2 Flashcards

1
Q

what is monophyletic group?

A

Group with a common ancestor and every one of its descendant species.

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2
Q

what is a paraphyletic group?

A

a group with a common ancestor but does not contain every descendant species

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3
Q

what is a polyphyletic group?

A

a group that does not contain a common ancestor of its members (ex: more than one common ancestor)

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4
Q

What is a root in a phylogenetic tree?

A

the basal (most ancestral) lineage on a phylogenetic tree

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5
Q

What is a node in a phylogenetic tree?

A

a branch point on a phylogenetic tree

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6
Q

What is a taxon in a phylogenetic tree?

A

a general term for a group of related organisms (ex: species, genus, etc)

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7
Q

What are homologous traits?
A. Traits that are functional and adaptive in one species but are not functional in another species.
B. Traits that are found in two or more species because the species have inherited this trait from their common ancestor.
C. traits that were originally selected for one function and then co-opted for a different function.
D. Traits that are found in two or more species because the species live in similar environments and independently evolved the traits due to shared selective pressure.

A

B.

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8
Q

Bats and hummingbirds both have wings and can fly. This is due to _____.
A. Divergent evolution
B. Convergent evolution
C. Co-adaptation
D. Co-evolution

A

B.

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9
Q

The basic conceptual approach to phylogenetic tree building assumes that:
A. Shared characters are homoplasies
B. Vestigial traits are not relevant.
C. Species with many characters states in common are more closely related than those with few character states in common.

A

C.

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10
Q

What is the fundamental idea behind parsimony?
A. The best phylogeny is the one that both explains the observed character data and posits the fewest evolutionary changes for a group of taxa.
B. The computed number of morphological or molecular distances between taxa indicates their relatedness.
C. The best phylogeny is the one that posits the greatest number of evolutionary changes for a group of taxa.

A

A.

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11
Q

Convergent evolution occurs when?
A. Two or more populations or species become more similar to each other because they are exposed to similar selective conditions.
B. Closely related populations or species diverge from one another because natural selection operates differently on each of them.

A

A.

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12
Q

What is synapomorphy?

A

A derivative trait that is shared in two populations because it was inherited from a recent common ancestor.

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13
Q

What is symplesiomorphy?

A

An ancestral character states shared by two or more lineages in a particular clade

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14
Q

What is polytony?

A

A node on a phylogenetic tree that has more than two branches arising from it.

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15
Q

What is a homologous trait?

A

A trait shared by two or more species because it was inherited from a common ancestor

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16
Q

What is homoplasy?

A

A trait that is similar in two species because of convergent evolution.

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17
Q

What is polarity?

A

The order in which different variants of a trait evolved over evolutionary time.

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18
Q

A type of mutation in which a region of one chromosome is moved to a different chromosome is called____?
A. Deletion
B. Translocation
C. Inversion
D. Duplication

A

B.
FEEDBACK: A translocation is a mutation in which a section of one chromosome moves to a nonhomologous chromosome (they could also be reciprocal if there is an exchange between nonhomologous chromosomes). A chromosomal deletion entails the loss of a large section of a chromosome. In contrast, duplication refers to an addition to the chromosomal segment and will result in additional genetic material. Finally, an inversion involves a 180° flip in a section of a chromosome. Study Figure 6.17 and compare all types of chromosomal aberrations.

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19
Q

An addition or deletion of one or two base pairs in a gene sequence results in a ______ mutation.
A. Transversion
B. Nonsense
C. Frameshift
D. Transition

A

C.
FEEDBACK: Because codons are made of three nucleotides, when an insertion or deletion mutation involves any number of codons that is not a multiple of three, it produces a frameshift mutation, which affects the translation of other codons and thus affects the production of amino acids and proteins. When an insertion or deletion mutation involves a multiple of three nucleotides, it does not disrupt the reading frame (the way in which adjacent base pairs are grouped into triplets and translated into amino acids). Examine Figure 6.16 on in-frame and frameshift mutations.

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20
Q

If one human protein contains 400 amino acids, how many nucleotides need to be in the exon of the corresponding gene to properly code for it?
A. 400
B. 120
C. 1200
D. 40

A

C.
FEEDBACK: The genetic code specifies the relation between codon triplets and the amino acids for which they code. If a polypeptide (primary structure of a protein) is 400 amino acids long, there should also be at least 400 codons in the corresponding mRNA. Each codon consists of three nucleotides, so 400 × 3 = 1200. The gene itself might be much longer than 1200 base pairs though because, at least in eukaryotes, the processed mRNA corresponds with exon sequences.

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21
Q

In sickle cell anemia, a point mutation leads to a replacement of one amino acid in a hemoglobin molecule, in a unit responsible for transportation of oxygen. This and any other mutation in a gene that causes a change in the amino acid sequence in a polypeptide chain is known as a __________ mutation.
A. Synonymous
B. Nonsense
C. Missense
D. Silent

A

C.
FEEDBACK: If the substitution causes the production of a different amino acid, such as in the case of sickle cell anemia, it is known as a missense mutation. If a base substitution does not change the amino acid that a codon normally produces, it is known as a synonymous mutation (also called a silent mutation). Finally, if a base substitution creates a stop codon where there was none previously, it is known as a nonsense mutation. Read the subsection titled “Genetic Variability and Mutation” in Section 6.3 and examine Figure 6.15.

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22
Q

In the 1850s and 1860s, Gregor Mendel bred pea plants and examined the way that traits were passed down across generations. His conclusions, although not accepted during his lifetime, established the foundation for the field of genetics. Of the choices listed, what is the most relevant summary of Mendel’s conclusions?
A. Garden pea plants are the best experimental model system to study heredity.
B. The hereditary factors responsible for traits such as seed shape and flower color are inherited as discrete units.
C. Recessive factors of inheritance blend after the first filial generation.
D. Hereditary material must be a nucleic acid.

A

B.
FEEDBACK: In the mid-1800s, a predominant view among naturalists was that traits blend together and therefore could be lost in future generations. This understanding of heredity was a limitation for Charles Darwin’s theory, and although Mendel and Darwin worked at about the same time, they did not know of one another. Mendel was an Augustinian monk and a plant breeder in the Austro-Hungarian Empire. With his fine mathematical skills, Mendel established the first genetic experiment and the discipline of genetic analysis. In his experimental research with tens of thousands of pea plants that he had bred, he concluded that traits do not blend, but rather that they are discrete in nature. Mendel named his discrete entities “factors of heredity” (today known as genes). Almost a century later, it became clear that genes are composed of DNA.

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23
Q

In their experiment in 1943 using E. coli, Salvador Luria and Max Delbrück tested two alternative hypotheses. The random mutation hypothesis and the acquired inherited resistance hypothesis make different predictions about the distribution of resistant mutants that will be observed upon exposure to bacteriophage (viruses that can infect and kill E. coli). Which of the following predictions, if proven, would support the acquired inherited resistance hypothesis?
A. At the time of exposure to the phage, all E. coli cells will be phage-sensitive. The process of exposure to the phage will induce phage resistance in a small fraction of the bacterial cells.
B. There will be wide variation in the number of phage-resistant E. coli colonies on each agar plate.
C. Regardless of the origin of these mutations, resistance to the phage will be heritable and will result in colonies of phage-resistant E. coli cells.
D.The phage-resistant E. coli cells will arise by random mutation even before the phage is present.

A

A.
FEEDBACK: Luria and Delbrück proposed two hypotheses. The first one (random mutation) predicts that prior to exposure to the phage, a few resistant E. coli cells will arise by random mutation. Once exposed to the phage, most cells will be killed, but the resistant cells will not. Instead they will reproduce and form new resistant colonies. The second hypothesis (acquired inherited resistance) proposes that at the time of exposure to the phage, all bacterial cells will be phage-sensitive. The process of exposure to the phage will induce phage resistance in a small fraction of the bacterial cells. This resistance will then be heritable, and the cells with induced resistance will go on to produce colonies of resistant cells. Compare the two hypotheses in Figures 6.20 and 6.21.

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24
Q

What is an important difference between transmission genetics and population genetics?
A. Transmission genetics deals with genotypes of individuals, while population genetics deals with genotype frequencies in a population.
B. Transmission genetics is based on quantitative models, while population genetics is based on qualitative models.
C. Transmission genetics requires information about inheritance, but population genetics does not.
D. Transmission genetics uses molecular biology, but population genetics does not.

A

A.
FEEDBACK: Transmission genetics characterizes the way the genotype of an individual offspring is related to the genotype of its parents. Population genetics deals with how genotype frequencies in a population are related to those of the parental population. Both types of genetics use quantitative models, molecular biology, and information about inheritance. See the beginning of Section 7.1 titled “Individual-Level versus Population-Level Thinking.”

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25
Q

What is phylogeny?

A

The study of the branching relationships between populations over evolutionary time.

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26
Q

How are phylogeny trees built up?

A

Analysing distribution of traits across populations.

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27
Q

What does phylogeny allow us to understand?

A

Evolutionary relationships between groups enable us to reconstruct the tree of life and gain insight into the history of evolutionary changes.

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28
Q

What are traits used for in phylogenetic trees?

A

They are used to infer patterns of ancestry and descent among populations. They are depicted on the trees.

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29
Q

By mapping traits onto trees what can we infer?

A

Possible to study the sequence and timing (history) of evolutionary events.

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30
Q

Are phylogenetic trees hypothesis?

A

Yes, they allows us to hypothesize between groups and tests it once we have additional evidence.

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31
Q

What are interior nodes? (Where branches meet)

A

Represents ancestral populations that are the common ancestors of the taxa at the ends of their branches.

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32
Q

What is a sister taxa?

A

Taxa derived from the same node.

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33
Q

What are two types of phylogenetic tree format? Are they the same?

A

Tree format or ladder format. They have the same info

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34
Q

Does rotating a node change relationships between taxa?

A

Nope, relationships are the same

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35
Q

When is a polytomy used for?

A

In cases where relationships among three or more groups are unresolved.

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36
Q

What is the purpose of phylogenetic tree?

A

The purpose is to use them is to figure out the evolutionary relationships between taxa and to identify “natural” group among taxa,those that reflect their true evolutionary relationships.

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37
Q

What is a clade?

A

A group of taxa that shared a common ancestor.

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38
Q

Are all classes monophyletic?

A

Yes

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39
Q

What are the two groups that fails to be monophyletic?

A

Polyphyly and paraphyly

40
Q

a polyphyletic group requires?

A

each group member to have each had an independent evolutionary origin of some diagnostic feature. (something in common)

41
Q

whats an example of a paraphyletic group?

A

fish (does not account for descendants: tetrapods)

42
Q

What does it mean when a tree is rooted?

A

there’s a clear indication of the direction of time.

43
Q

unrooted trees are older or younger than rooted trees?

A

more recent (younger) than interior nodes but cannot tell which of multiples interior nodes is more recent than others.

44
Q

Can you root an unrooted tree?

A

yes, it will produce different tree depending on where you root it.

45
Q
A
46
Q

What are the three types of phylogenies?

A

Cladograms, phylograms, and chronograms

47
Q

What is cladogram?

A

Shows sequence of evolution and identifies monophyletic clases but no information about genetic or temporal distance between species. Brach tips will be aligned.

48
Q

What is a phylogram?

A

Is a tree that with branch lengths that represent evolutionary change.

49
Q

What is a chronogram?

A

Branch legth scaled to show TIME since divergence of clases. (often based on fossil records)

50
Q

What are homologous traits?

A

Traits that are derived form a common ancestor. Ex: all mammals possess hair

51
Q

What is an analogous trait?

A

Traits that are shared by different species not because they were inherited from a common ancestors but because they evolved independently.
Ex: wings on birds and insects

52
Q

How does divergent evolution occur?

A

Occurs when closely related populations diverge from each other because selection operates differently on them

53
Q

How does convergent evolution occur?

A

Results are similar in solution to an evolutionary problem converged upon by different organisms independently from each other.

54
Q

What is ancestral trait?

A

Trait present in an ancestor

55
Q

What a derived trait?

A

Modified trait from an ancestor

56
Q

What is synapomorphy

A

Shared derived trait

57
Q

What is homoplasy?

A

Trait shared not because it was inherited but because it was independently evolved.

58
Q

If a trait is shared but not derived, what is it called?

A

Symplesiomorphy

59
Q

What are strategies to avoiding homoplasies and symplesiomorphies?

A
  1. Use traits that change relatively slowly in evolutionary time
  2. Use many traits to build a tree.
  3. Have multiple outgroups to help identify ancestral values of traits
60
Q

what are the two methods needed for building a tree?

A

Parsimony and distance methods

61
Q

What is parsimony?

A

basic idea is to build a tree that requires the fewest evolutionary changes

62
Q

what is distance method?

A

use of UPGMA method by starting with most recent nodes and moving down to progressively older nodes.

63
Q

what are the two rules of parsimony?

A
  1. if daughter of a node share one or more possible states of a trait then we assign the shared states to the nodes.
  2. if the two daughters of a node share no stated in common we assign to the node all the possible states for both daughters.
64
Q

what are the parsimony limitations?

A

parsimony is limited when evolutionary changes occur at different rates on different branches of phylogeny.

65
Q

what is distance methods based on? what does it count?

A

based on morphological measurement, in living species it will count the difference in DNA sequences or amino acid differences coded for to build trees.

66
Q

since phylogenies are hypothesis, how is confidence in the tree measured (statistical confidence)?

A

bootstrap resampling

67
Q

what is bootstrap resamping?

A

based on the idea that the data set used for a tree is based on is itself one possible set of data that the tree could have been built with.
It resamples the tree and measure how many can be rebuilt and how many it matches the original 90% of the time.

68
Q

what is an example of bootstrap analysis?

A

monophyly of the placental and marsupial mammals. showed marsupials and placental mammals formed a monophyletic clade 100% of the time.

69
Q

what is transmission genetics?

A

mechanism by which genes are passed from parent to offspring. it is governed by the principles of inheritance. Track individual traits along individual lineage.

70
Q

what is population genetics?

A

governed by the concept of heritability which involves a comparison of parental and offspring populations.

71
Q

what is particulate inheritance?

A

genes do not blend together and favorable variant can increase over time as a result of selection.

72
Q

what is law of segregation?

A

each individual has two gene copies at each locus and these are segregated (split-up) during formation of gametes so only one copy goes into each gamete.

73
Q

what is the law of independent assortment?

A

alleles at different loci are inherited independently.

74
Q

Does inheritance blend or is it particulate?

A

Particulat, Rather than blending where gene turns into something else and it passed on that way for many generations.copies discrete particles (genes) are passed from one generation to the next

75
Q

which nucleotides are purines?

A

adenine and guanine

76
Q

which nucleotides are pyrimidines?

A

thymine and cytosine

77
Q

what is a different version of a gene called?

A

allele

78
Q

the combination of genes an individual has at a locus is referred to as

A

genotype

79
Q

if heterozygote is phenotypically intermediate what is that called?

A

incomplete dominance

80
Q

what are the four sources of new genetic variation for population?

A
  1. recombination (new combination of genes)
  2. mutation (new genes)
  3. migration
  4. lateral gene transfer
81
Q

what is crossing over event?

A

pieces of chromosomes are exchanged between chromosomes to produce new and unique chromosomes.

82
Q

what is the ultimate source of all variation?

A

mutation

83
Q

what is a transitional substitution?

A

purines to purines (A to G)
or
pyrimidines to pyrimidines (T to C)

84
Q

what is a transversional substitution?

A

purine to pyrimidine or vice versa

85
Q

what does missense mutation do?

A

encodes for a different amino acid

86
Q

what does a nonsense mutation do?

A

prematurely stops translation

87
Q

do mutations arise when needed or are random?

A

random

88
Q

Salvador Luria and Max Delbruck killed of neo-Lamarkian ideas how?

A

disprove acquired hereditary resistance which indicates that at the time of exposure to environmental factors would induce resistance in some small percentage of bacteria that would produce resistant offspring.

89
Q

Salvador Luria and Max Delbruck supported what in mutation?

A

mutations are random and in their experiment some bacteria would have randomly developed mutation that helped them survive exposure to phage.

90
Q

what is allele frequency?

A

the proportion of the alleles at a given locus in a population that is represented by a particular allele.

91
Q

what is a Hardy-Weinberg equilibrium?

A

a population that is not evolving.
allele frequencies remain constant across generations unless acted by some force.

92
Q

what are some factors that cause a deviation from H-W equilibrium?

A
  1. genetic change
  2. finite population- genetic drift, random events that affect allele frequencies.
  3. non-random mating- inbreeding, outbreeding
  4. exchange of alleles among populations- migration
  5. Natural selection for or against certain alleles.
93
Q

what is heterozygote advantage (overdominance)?

A

results in a balanced polymorphism in a population. heterozygote is best combination/ has higher survival ex: sickle cell.

94
Q

what heterozygote disadvantage (underdominance)?

A

Where heterozygote has lower chance of survival

95
Q

directional selection on dominant alleles?

A

fast then slow favored by selection.

96
Q

directional selection on recessive alleles?

A

slow then fast for recessive alleles favored by selection