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Cell Biology Final > Exam 2 > Flashcards

Exam 2 Flashcards

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1
Q

Which of the following types of proteins are likely to have a signal sequence?
-Proteins that are secreted
-Proteins with transmembrane domains
-Proteins destined for the lumen of many organelles
-Two of the above
-All of the above

A

All of the above

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2
Q

Which of the following amino acid sequences would you expect to find on a protein that gets imported into the nucleus

A

PKKKRKV

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3
Q

A vesicle budding from the Golgi that is destined for the endoplasmic reticulum would be stimulated by the ___ GTPase and be moving the ___ direction

A

Arf1; retrograde

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4
Q

Which vesicle coat protein complex would be used for a vesicle made on the Golgi and heading to the ER?

A

COPI

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5
Q

The kinase domain of tyrosine kinase receptors are on the cytoplasmic side of the plasma membrane and are at the C-terminus of the protein. Thus, you would expect that the C-terminus would be found on the _____ side of the ER membrane immediately following translation, and that it would be on the
_____ side of the membrane of the vesicle that transports it to the plasma membrane.

A

Cytoplasmic; cytoplasmic

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6
Q

Which protein complex would you expect to be degraded in the transition from metaphase to anaphase?

A

Cohesin

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7
Q

In COPII coated vesicle formation, which protein(s) is/are a GTPase effector that binds the membrane and recruits the outer coat proteins?

A

Sec23/24

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8
Q

What is the function of reticulons in the endoplasmic reticulum?

A

They generate curvature in the ER membrane

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9
Q

Why is the level of cholesterol higher in the Golgi than it is in the ER?

A

Because cholesterol has a high affinity for sphingolipids that are made in the Golgi

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10
Q

Which family of GTPases is involved in the movement of vesicles from the donor membrane to the acceptor membrane?

A

Rab

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11
Q

N-linked oligosaccharides involve the covalent linkage of branched polysaccharides to ____ proteins. This takes place on the ____
side of the ER membrane.
in target

A

asparagine; ER lumen

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12
Q

In which nuclear subdomain would you expect to find rRNA genes being transcribed and the assembly of pre-ribosomal components?

A

Nucleolus

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13
Q

The proteins Get1/2/3 are involved in which process?

A

Inserting proteins with C-terminal transmembrane domains into the ER membrane

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14
Q

What is the function of a BAR domain protein?

A

Induce and stabilize membrane curvature

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15
Q

When Ran enters the nucleus, it rapidly _____ due to the presence of a Ran ____ on the chromatin

A

Releases GDP; GEF

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16
Q

Which of the following steps in translation uses a GTPase?
1. Initiation
2. Elongation
3. Termination

A

1,2 and 3

17
Q

Which of the following occurs once the SRP binds a signal sequence?
-Translation is paused
-The SRP becomes GTP bound and interacts with the SRP receptor
-The ribosome relocates to the endoplasmic reticulum
-the exit pore of the ribosome aligns with the translocon
-all of the above

A

All of the above

18
Q

Which of the following is NOT a form of protein acylation used to anchor proteins to a membrane?

A

Acetylation

19
Q

Which component of the initiation complex is a major regulatory target to slow or stop mRNA translation?

A

Elf-2a

20
Q

A protein that will be secreted ____ have a signal sequence and ___ have a transmembrane domain

A

Will; will not

21
Q

The S1P and S2P proteases in the Golgi are involved in which cellular process?
1. Unfolded protein response
2. Regulation of cholesterol synthesis
3. N-linked oligosaccharide addition

A

1 and 2 only

22
Q

Which of the following represents the first (i.e. smallest) level of organization of DNA packaging?
-30 nm fiber
-nucleosome
-chromatin fiber
-chromosome

A

Nucleosome

23
Q

Which of the following is NOT a function of the endoplasmic reticulum?
-Nuclear compartmentalization
-Lipid signaling and transfer
-Calcium storage and release
-Detoxification of compounds
-Synthesis of cytoplasmic proteins

A

Synthesis of cytoplasmic proteins

24
Q

Which of the following is the main regulatory step in the biosynthesis of cholesterol?
-The formation of squalene from two farnesyl groups
-The formation of HMG CoA from Acetyl CoA
-The final (22nd) step that forms mature cholesterol
-The conversion of HMG CoA to Mevalonate

A

The conversion of HMG CoA to Mevalonate

25
Q

Which of the following are potential modifications that you might find on the tails of histones?
-Acetyl lysine
-Tri-methyl lysine
-Mono-methyl lysine
-Two of the above
-All of the above

A

All of the above

26
Q

Removal of an acetyl group from ____ on histone tails causes the associated DNA to be ____ accessible for transcription

A

Lysine; less

Cell Biology Final (5 decks)

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