Exam 2 Flashcards
How many kcals per gram to fats have?
9
What % of the typical american diet is from fat?
34%
What are triglycerides?
3 Fatty acids attached to a glycerol molecule
What is the major form of lipid in food and body?
Triglycerides
Short Chain Fatty Acids
Range from 4-7 carbons
remain liquid at cooler temperatures
ex. Milk
Medium Chain fatty acids
8-12 carbons long
Solidify when chilled, but liquid at room temperature
ex. Coconut Oil
Long Chain fatty acids
greater than 12 carbons
Solid at room temperature
Beef fat
Saturated Fatty Acids
Contain carbons in a chain that are bound to two hydogens (no double bonds)
- Most animal fats, palm oil and coconut oil
- less susceptible to spoilage
Unsaturated Fatty Acids
- Contain some double bonds
- Can be monounsaturated or Polyunsaturated
Monounsaturated fatty acid examples
olive oil, avocado– have one double bond
Polyunsaturated fatty acid examples
- Omega 3
- –ALA (flax, canola oil, nuts)
- –EPA, DHA “Long Chain” (fish)
- Omega 6 (Linoleic Acid, Corn, Safflower oil, nuts
Cis Bonds
results in bent chains
Trans fatty acids
occur naturally in small amounts, but most are created by hydrogenation
- results in straight chains
- lengthens the shelf life
Trans Fatty Acid food sources
Shortening, Margerine, Biscuit, Chocolate Chip Cookies
Phospholipids
lipids attached to a phosphate group
Phosphoglycerides
1 FA attached to a glyceride backbone
ec. lecithin
Can act as emulsifiers– allow oil and H20 to mix
Form a lipid bilayer in call membranes that regulate what can pass into and out of a cell
Sterols
type of lipid found in plants and animal- has a multiple ring structure
Do not dissolve well in water
Cholesterol
a type of sterol found only in animals
- the liver can manufactore all needed cholesterol, so it is not needed in the diet
- 90% of cholesterol in the body is found in cell membranes
- is needed to synthesize vitamin D and steroid hormones
Food Sources of Cholesterol
Online animal products
- eggs
- beef liver
Lipid digestion
-Small amount in mouth due to gastric lipase produced in the stomach
-liver produces bile, stored in gall bladder and released in SI
-Pancrease produces pancreatic lipase-released inSI to break down triglycerides
Short/medium chain trig. are water soluble, can be aborbed into bloodstream
-In SI products of fat digestion and bile acids form into micelles which diffuse out into mucosal cells
-in mucosal cells fatty acids and monoglycerides are reassembled into triglcerids, form into chylomicrons and enter lymph
-Very efficient, very little fat is lost in feces
Lipoproteins
Combination of water insoluble lipids, phospholipids and proteins, act as a transport vehicle
-help to transport triglycerides, cholesterol and fat soluble vitamins from the SI and stored lipids from the liver
Chylomicrons
combination of diet derived triglycerids, cholesterol, phospholipids and a small amount of protein
Help transport long-chain fatty acids into the lymphatic system and into the blood stream without passing through the liver
-Deliver triglycerids to the body cells
Lipid transport and delivery
- Chylomicron formed in mucosal cells pass into lymph, which drains into the blood, they circulate in the blood delivering triglycerides to body cells
- Lipoprotein lipase breaks down triglycerides in chylomicrons into fatty acids and glycerol which can then enter the surrounding cells
- Remaining chylomicron parts are removed to the liver to be disassembled
- VLDLs are made in the liver and transport lipids away from the liver to body cells
5IDL particles that remain after the triglycerides are removed are returned to the liver, or transformed in the blood into LDL particles - To deliver cholesterol, LDL particles bind to LDLreceptors in the cell membrane, this allows the LDL to enter the cell whre cholesterol and other components can be used
7.HDL particles pick up cholesterol from other lipoproteins and body cells and return it to the liver, some is broken down, some is transferred to organs that synthesize hormones
Chylomicron
- largest lipoproteins and contain the greatest proportion of triglycerids
- form in mucosal cells, pass into lymph, then into blood stream
- deliver triglycerides to the body cells
VLDL
- smaller than chylomirons
- contain a high proportion of truglycerides
- made in liver
- transport lipids away from the liver
- deliver triglycerids to body cells wi/ help of lipoprotein lipase which removes triglycerides from VLDLs making IDLs
LDL
Contain higher proportion of cholesterol than other lipoproteins, and less triglycerides
Made in blood from IDLs
Deliver cholesterol by binding to LDL receptors in the cl membrance
High levels of LDLs in the blood are associated with an increased risk for heart disease
HDL
high in cholesterol and are the densest lipoproteins due to their high protein content
- pick up cholesterol from other lipoproteins and body cells and return it to the liver
- prevent cholesterol from depositing in the artery walls
- high levels of HDL are associated with a reduction in heart disease risk
What is the major lipid producing organ in the body?
Liver
Can make triglycerides from excess protein and carbohydrates
lipoprotein lipase
removes triglycerids from VLDLs creating intermediate density IDLs
adipose tissue
store triglycerides
define body shape, provide stored energy, insulate body from temp changes, and protect internal organs against physical shock
Use of lipids in body
lubricate body surfaces, such as the mucous membranes of the eyes
Cholesterol uses
used to make several hormones, including sex hormones and cortisol
Polyunsaturated fatty acid uses
help regulate blood pressure and blood clotting
Essential Fatty Acids
have to be consumed in the diet
-important for growth, skin integrity, fertility, and the structure and function of cell membranes
Eicosanoids
made from omega 3 and omega 6 fatty acids
help regulate blood clotting, blood pressure and immune function
Essential fatty acid deficiency symptoms
dry and scaly skin, liver abnormalities, poor wound healing, growth failure in infants, impaired hearing and vision
Omega 6 derived eicosanoids
increase inflammation, increase blood clotting, increase blood pressue
Omega 3 derived eicosanoids
decrease inflammation, decrease blood clotting and decrease blood pressure
sources of omega 6/linoleic acids
vegetable oils and meats
sources of omega 3/ alpha linolenic acid
flaxseed, walnuts, soy
Energy from triglycerides
fatty acids and glycerol can be used to produce energy in the form of ATP (glycerol foes in as glucose or pyruvate… fatty acids go in as acetyl CoA)
Beta oxidation of fatty acids begins the metabolic pathway to produce ATP
Feasting
When excess energy is consumed it is stored as triglycerides in adipose tissue
Fasting
When no food has been eaten for a while, triglycerides from adipose tissue are broken down, releasing fatty acids as an energy source
Atherosclerosis
a disease in which lipids and fibrous materials are deposited in artery walls— if clot goes to the brain it’s a stroke, if it goes to the heart it is a heart attack
Age as a risk factor for heart disease
-non modifiable
as age increases (men over 45, women over 55) risk increases
-almost half of people with cardiovascular disease are 60 or older
Gender as a risk factor for heart disease
men @ risk at a younger age
-estrogen acts as protection
Genetic Background as a risk factor for heart disease
if a male family member had it before 55, or a female had it before
Blood pressure as a risk factor for heart disease
high blood pressure > 140/90 can damage blood vessel walls, causing heart to work harder
Diabetesas a risk factor for heart disease
blood glucose >126/100 damages blood walls
obesity as a risk factor for heart disease
increases blood pressure, cholesterrol, diabetes, increases the amount of work the heart needs to do to pump blood through the body
blood lipid levels as a risk factor for heart disease
cholesterol >200
LDL>130
HDL<40
mean you are at high risk
smoking as a risk factor for heart disease
increases risk
activity as a risk factor for heart disease
regular exercise decreases risk
Dietary factor to reduce heart risk
- whole foods
- polyunsaturated and monounsaturated fats
- plant foods, b vitamins, antioxidants
- moderate alcohol consumption
- fiber (binds cholesterol so you absorb less)
Dietary factors that increase heart risk
cholesterol saturated fat (increased LDL) Transfat (increase LDL, decreased HDL) Sodium (increased blood pressue) Excess sugar (increased circulating triglycerides) Excess energy (obesity)
Red meat and colon cancer
diets high in red meat are associated with higher incidence of colon cancer
AMDR for fat
20-35% total kcal (for >19, varies based on life stage)
What are there AIs for in Fats
AI, ALA
2010 Dietaey guidelines for fat
- limit intake of solid fats
- encourage fat from liquid oils, nuts, fish
AMDR for fat: pregnant women
AMDR for fat not increased
AI for essential fatty acids are slightly higher
Infant Fat intake
Infants need a diet with 40-55% energy as fat
Ages 1-3 fat intake
30-40% of energy intake
ages 4-18 fat intake
25-35%
Elderly fat intake
Same as young, 20-35%
fat free
less than 0.5g of fat per serving
low fat
3g or less of fat per serving
reduced or less fat
25% less fat per serving than the regular product
saturated fat free
less than 0.5 g saturated fat
low saturated fat
1g or less of saturate fat, not more than 15% of calories from saturated fat per serving
reduced or less saturated fat
at least 25% less saturated fat than reference product
cholesterol free
less than 2mg of cholesterol
reduced or less cholesterol
contains at least 25% less cholesterol than regular product
lean
less than 10g of fat, 4.5 g or less of saturated fat, less than 95mg of cholesterol per 100g
extra lean
contains less than 5g of fat, less than 2g of saturated fat and less than 95mg of cholesterol per serving and per 100g
problems with olestra
is a fat based substitute that can reduce the absorption of fat-soluble vitamins, can cause GI problems
How much cholesterol in an egg?
200mg
What does an egg give?
6g PRO, Vit A, Vit D, 200mg cholesterol
Egg consumption
1 egg/day did not result in an increased cardiovascular risk , except for those with diabetes
Dietary Guidelines for eggs and cholesterol
1 egg a day is OK, Limit dietary cholesterol to <300mg daily
Coconut oil
-mostly saturated fat, medium length chains
transported via the liver
Where do the calories in alcohol come from?
Carbohydrates and alochol
Definition of a drink
5oz wine, 12oz beer, 1.5 oz spirits
Alcohol absorption
- is rapidly absorbed by simple diffusion along the entire GI tract
- 20% is absorbed in the stomach
- abosorbed alcohol is rapidly distributed throughout all body water compartments
- 90% of alcohol is metabolized by liver, 5% is excreted into the urine, and the remainder is elimated via the lungs
Weight and BAC
higher weight, more body water, dilute alcohol content
Gender and BAC
men have more body water and alcohol dehydrogenase, so lower alcohol levels
Food and BAC
food in stomach slows alcohol absorption, so lowers alcohol levels
Alcohol Dehydrogenase
Primarily found in liver, stomach, works for small amount of alcohol
Microsomal ethanol oxidizing system
found in liver, used when larger amounts of alcohol are consumed. needs energy and O2
Allcohol metabolism for small amouts
ADH breaks down alcohol to produce acetaldehyde, decreated to acetyl coa, the breakdown of alcohol and acetaldehyde releases electrons that can be used to produce ATP, but also results in inhibition of the citric acid cycle, limiting breatdown, so leads to fat build up
Alcohol metabolism large amounts
MEOS activity increases, converting alcohol into acetaldehyde which is broken down to acetyl coa, can’t enter the citric acid cycle because it is inhibited, instead it forms fatty acids which accumulate in the liver andform fatty liver
short term effects of alcohol consumption
interfere with organ function several hours after ingestion, reasoning, vision, speech
effects of chronic alcohol consumption
interferes with nutritional status, produces toxic compounds, inreases cancer risk
Liver damage: fatty liver, alcoholic hepatitus, cirrosis
Hypertension, heart disease and stroke,
how does excessive alcohol consumption cause malnutrition?
decreases overall nutrient intake, interferes with nutrient absorption, storage, metabolism and excretion, increases kcal intake
Chronic alcohol use and birth defects
increases the risk of fetal alcohol spectrum disorders, including fetal alcohol syndrome when consumed during pregnancy
Chronic alcohol use and gastrointestinal problems
damages the lining of the stomach, small intesting an contributes to development of pancreatitis
Chronic alcohol use and liver disease
causes fatty liver, alcohol hepatitus and cirrhosis
Chronic alcohol use and malutrtion
decreases alcohol absorption and alters the storage, metabolism, and excretion of som vitamins and minerals
Chronic alcohol use and cardiovascular disorders
associated with cardiomyopathy, hypertension, arrhythmias and stroke
Chronic alcohol use and cancer
increases risk of cancers of upper digestive tract, including the esophahus, mouth, pharync and larynx as well as the liver, pancreas, breast and cancer
Chronic alcohol use and pshychological disturbances
causes depression, anxiety and insomnia and is associated with higher incidence of suicide`