Exam 2 Flashcards
What are social determinants of health?
Conditions in the environments where people are born, live, learn, work, play, worship, and age that affect a wide range of health, functioning, and quality-of-life outcomes and risks
What are the 5 domains of the social determinants of health?
- Economic stability
- Education access and quality
- Healthcare access and quality
- Neighborhood and built environment
- Social and community context
What are the unethical research studies of the past?
Nazi doctors in the 1940s, Willowbrook State School for Children with Intellectual Disabilities on Staten Island in the 1950s, Puerto Rico Pill Trial in the 1950s, and CIA’s MK-UKTRA program in the 1950s.
What did the Nazi doctors in the 1940s do?
Nazi doctors conducted human experiments on prisoners in concentration camps in the 1940s
What did the Willowbrook State School for children with intellectual disabilities on State Island, NY in the 1950s do?
Discovery of 2 strains of hepatitis - A and B - and how they spread… developed a prototype hepatitis B vaccine
What happened during the Puerto Rico Pill Trial in the 1950s do?
Women were not told that they were involved in a clinical trial or that the pill was experimental and had potentially dangerous side effects
What happened during the CIA’s MK-ULTRA program in the 1950s?
Unwitting subjects endured psychological torture ranging from electroshock to high doses of LSD
What was the Tuskegee Study?
Involved 600 black men - 399 with syphilis, 201 who did not have the disease.
Researchers told the men they were being treated for “bad blood,” a local term used to describe several ailments, including syphilis, anemia, and fatigue.
The men did not receive proper treatment needed to cure their illness.
In exchange for taking part in the study, men received free medical exams, meals, and burial insurance.
The study lasted for 40 years instead of 6 months and was conducted without the benefit of patients’ informed consent.
What research practices did the Tuskegee Study change?
$10 million settlement. US government promised to give lifetime medical benefits and burial services to all living participants. The Tuskegee Health Benefit Program (THBP) was established to provide these services.
The National Research Act was signed into law in 1974.
What is the National Research Act?
Created National Commission for the Protection of Human Subjects in Biomedical and Behavioral Research.
Required researchers to get voluntary informed consent from all persons taking part in studies.
Required establishment of Institutional Review Boards (IRBs - review and decide whether studies meet ethical standards)
What are ACEs?
Adverse childhood experiences
What are types of ACEs?
Abuse:
- physical
- emotional
- sexual
Neglect:
- physical
- emotional
Household Dysfunction:
- mental illness
- incarcerated relative
- mother treated violently
- substance abuse
- divorce
What is the impact of ACEs?
Toxic stress from ACEs has a direct effect on brain development, resulting in changes in:
- decision making
- learning and growth
- forming healthy relationships
What are the lasting impacts of early adversity?
Injury: traumatic brain injury, fractures, burns.
Mental health: depression, anxiety, suicide, PTSD.
Maternal health: unintended pregnancy, pregnancy complications, fetal death.
Infectious disease: HIV, STDs.
Chronic disease: cancer, diabetes.
Risky behaviors: alcohol and drug abuse, unsafe sex.
Opportunities: education, occupation, income.
What is the stress response system?
Prolonged release of stress hormones activates SNS resulting in the release of stress hormones, such as cortisol.
When stress hormones are released in excess of normal, it has a negative impact on different areas of the brain… other organs:
- HPA axis.
- Amygdala.
- Prefrontal cortex.
- Hippocampus.
What affect do ACEs have on life expectancy?
Life expectancy with 6+ ACEs: 60 years.
Life expectancy without ACEs: 80 years.
Preventing ACE strategy: strengthen economic supports to families
Approach:
- strengthening household financial security
- family-friendly work policies
Preventing ACE strategy: promote social norms that protect against violence and adversity.
Approach:
- public education campaigns; legislative approaches to reduce corporal punishment
- bystander approaches
- men and boys as allies in prevention
Preventing ACE strategy: ensure a strong start for children.
Approach:
- early childhood home visitation
- high-quality childcare
- preschool enrichment with family engagement