Exam 2 Flashcards
Nutrition
The food we eat, air we breathe, water we drink, supplements we ingest, and all that we do that literally feeds or nourishes the body for its own health benefit
Conditionally essential AA
AA that are only required during stressed or diseased conditions
DO we need to know the ones
One vitamin we can synthesize without food
Vitamin D
B/c it is a hormone
Synthesized in skin, melanin will block UV and thus blocks VitD synth
Do we need to know specific vitamins
Vitamin C
Ascorbic acid
Powerful vitamin for immune function and oxidative stress
Minerals
Need trace amounts to survive on top of CHONPS
Digestion
The breakdown of macromolecules & essential nutrients into the smaller bare molecules
Complete digestive system
Food goes in one end and waste out the opposite, some organisms have waste and food in same hole
Digestion flow chart
GO over the flow chart
Where does digestion begin
Mouth (biological answer)
Cooking and chopping makes digestion easier for us
Mouth
Mechanical digestion: teeth and tongue break food down into smaller pieces
Chemical digestion: Salivary glands produce saliva with chemical enzymes to break down food
pH = 6-7
Chewing and metabolic rate
Increases metabolic rate by 10-15%, about a kcal a min
Salivary Amylase (Ptyalin)
Enzyme in saliva that breaks down starch to maltose
pH 6.5-7
Major components of saliva
Mucus, Amylase, lingual lipase, electrolytes, proteins and enzymes
(99%) water
Taste buds
Different for everyone
Mini pores with “hairs” on the tongue
Lingual (mouth) lipase
produced by tongue (activated by taste)
Breaks triglycerides into FA and glycerol
Most active at a pH of 3.5 so travels to stomach to be active
Peristalsis
Involuntary muscle contraction to move food to the stomach
Aided by water, exercise and fiber
Takes ~6 seconds
Stomach
Uses sphincters to churn up food in acid enzyme mix to break it down further
Storage for ~4 hours
Eating too much or things that are hard to break down you can feel it churning.
Stomach acid (hydrochloric acid)
pH around 1.5-2 to break through tough proteins and other essentials
Mucous layer keeps pH in check
Peptic ulcer
Hole in your stomach
can be caused by disease or bad diet
Pepsin
Main enzyme in stomach for protein breakdown
Regulated by pH (active at <3)
low pH releases it zymogen (pepsinogen) allowing pepsin to work
Lipase
Breakdown lipids in stomach
Lipid digestion
Mechanical churning of the stomach also keeps hydrophobic molecules separated from coalescing. Smaller droplets are easier for the enzyme to work on
Small intestine
6 meters (18ft) long. 5 hours to be processed and digested here
Duodenum, Jejunum, Ileum
Villi
In small intestine to increase SA for absorption and digestion
Duodenum
First part of Small intestine
Mix with bile from gallbladder and digestive juice from pancreas
HCO3- raises pH to aorund 6.5
Bile
Made in liver, stored in gallbladder
Helps with digestion, absorption of fats via emulsifying, excretion
Composed of bile salts, phospholipids, cholesterol, bilirubin
Pancreas
Helps break down food, control blood sugar, tell your stomach when to empty, etc.
Release pancreatic lipase and pancreatic amylase
Jejunum
Absorb sugars, AA, and FA
Ileum
Absorb any remaining nutrients that did not get absorbed by duodenum or jejunum
Type of transport for the main molecules
Active transport: Glucose, AA
Facilitated diffusion (active): Monosaccharides
Simple diffusion: triglycerides
Osmosis: Water
Trypsin
AA cleaving enzyme in SI
Has zymogen (trypsinogen)
Can cause pancreatitis if not regulated
Nucleotide breakdown
Broken down by nucleases and are absorbed by active transport
We uses their sugar residues
Vitamin/mineral absorption
Mostly absorbed in ilium
Ca2+ can be actively or passively (osmosis) transported into blood. Supplementation promotes passive
Large intestine
~ 5 feet long
10 hours to several days for processing with average 36 hours. Full of bacteria
Absorbs water via osmosis and the aid of mechanical contractions which also push electrolytes into the blood
Chyme
Semi-fluid mass of partly digested food that is left after the SI
Bifidobacteria
Help modulate immune response, regulate other gut bacteria, prevent tumor formation, produce vitamins
Escherichia coli (E Coli)
Help produce vitamin K2, keep bad bacteria in check. Some strains can cause disease
Lactobacilli
Produce vitamins and nutrients, boost immunity, protect against carcinogens
Campylobacter
(Food poisoning) C. Coli and C. Jejunii most commonly associated with human disease. Ingested through contaminated food
Clostridium difficile
Dangerous when it proliferates following a course of antibiotics
Enterococcus Faecalis
Common cause of post-surgical infections
Gas formation
Air can be ingested through esophagus
Non-digestible carbs are broken down without O2 and ferment –> produce gas
Homeostasis
Maintain stable internal environment, even when external environment changes
Factors that must remain stable for homeostasis
Temperature, blood pH, water levels, blood glucose
Insulin
Released by pancreas when glucose increases in the blood. The “key” that unlocks the glucose channel
Glucagon
Released by pancreas when low blood sugar and stimulates glycogen breakdown
Type 1 diabetes
Genetic autoimmune disease
Immune system confuses insulin producing cells in pancreas for a threat so it destroys them
Type 2 diabetes
Genetic and environmental factors
Pancreas produces too much insulin the receptors stop functioning or don’t recognize the insulin anymore
Caused by stressful and/or sedentary lifestyle
“troph”
Nourishment or simply food
See flow chart on slide 219
Hetero
Fuel from different organic substance
Auto
Fuel from inorganic substance
Chemo
Fuel from organic substance with some exceptions like sulfur and iron