exam 2 Flashcards
What is cardiac output
-stroke volume x heart rate
-normal ab 5 L/min
What is the systemic vascular resistance (SVR)
-force opposing flow
-radius of small arteries & arterioles
factors influencing blood pressure
cardiac
-heart rate, contractility, conductivity
sympathetic nervous system
-vasoconstriction, vasodilation
renal fluid volume control
-renin-angiotension-aldosterone system, natriuretic peptides
neurohormonal
-vasoconstrictors (angiotension & norepinephrine)
local regulation
-vasodilators (prostaglandins, nitric oxide)
-constrictors ( endothelin)
What are the biological differences between men and women?
more common before 55 yrs old for men and after 55 for women. For women estrogen decrease, overproduction of pituitary hormone, & weight gain. for men myocardial infarction more likely than CVA
Health disparities rt hypertension for black people
-highest prevalence worldwide
-females> males
-increase end-organ damage
-increase mortality
-less responsive to ACEI
Health disparities rt hypertension for hispanics
-decreased awareness
-less likely to receive treatment
- lower rates of control
facts rt hypertension in older adults
-over age 55=90% chance of developing hypertension
-physiologic changes contribute to HTN
-increased sensitivity to BP changes
-orthostatic hypotension common
primary hypertension
-increased BP with no identifiable cause
-essential or idiopathic
- 90-95% of adult cases
secondary hypertension
-increase BP due to specific underlying cause
- 5-10% of adult cases
patho rt primary hypertension
-sustained increased systemic vascualr resistance (SVR)
-or increase cardiac output (CO)
-heredity, water & sodium retention, altered renin-angiotension mechanism
-stress: psychologial and physiologic, insulin resistance, endothelial cell dysfunction
Symptoms rt secondary hypertension (if not asymptomatic)
-fatigue
-decreased activity tolerance
-dizziness
-palpitations
-dyspnea
target organs rt to hypertension
cardiac
cerebrovascular
peripheral vascular
renal
retinopathy
diagnostic studies rt hypertension
history & physical
blood pressure
urinalysis
BUN and creatine, GFR
serum electrolytes
serum lipid profile
ECG
invasive method for blood pressure measurement
arterial catheter provides direct measurement
Common diuretics?
thiazide, loop, potassium-sparing, adlosterone, receptor blockers