Exam 2 Flashcards
schizo- positive s/s
change in behavior/thoughts
ex. delusions, hallucinations
schizo- phase 1-premorbid
poor peer relationships/school performance
shy
first noticed by family
schizo- phase 2- prodromal
cognitive impairment, OCD, social withdrawal
schizo- phase 3- schizophrenia
full blown psychosis
delusion, hallucinations, dec functioning
schizo- phase 4- residual
flat affect
no s/s of active psychotic phase
schizo- negative s/s
withdrawn, social isolation, risk for suicide (anhedonia) (can’t experience pleasure)
volition (no goal-oriented activity)
waxy flexibility- consistent degree of resistance against passive mvmnt
posturing
schizophrenia
inability to differentiate btw what’s real and what’s not real
affects speech, affects, motor mvmnts
depression vs blues
depression questioned when pt unable to adapt and s/s impair daily functioning
*major depressive disorder most common
distress interferes w/ social, occupational, cognitive and emotional functioning
depression and bipolar
bipolar disorder misdiagnosed as depression
depression- epidemiology
x2 women v men- less pronounced w/ age
effects low and high socioeconomic
inc risk if single
seasonal (seasonal affective disorder is separate condition)
depression- biochemical component
inc acetylcholine
dec serotonin (cognition, irritability, appetite)
dec dopamine (regulates mood)
dec norepinephrine (ability to deal w/ stressful situations)
depression- endocrine disturbances
HPA- excessive cortisol (inc neurotoxicity and reduced neurogenesis)
HPTA- dec TSH= blunts circadian rhythm
depression- physiological predisposing factors
med side effects, electrolyte disturbance, hormonal disorder, nutritional deficiencies
depression- childhood depression-
disruptive mood dysregulation disorder
hard to diagnose w/ changing hormones
onset <10 yrs
depression- adolescence
2nd leading cause death for 15-24 yrs old
depression- senescence (elderly)
males >85 yrs have 4x national rate
depression- postpartum
1-2/1000 have severe depression
50-85% have “the blues”
10-20% have moderate depression
psychoanalytical theory- depression
S. Freud
loss is internalized and becomes directed against the ego
(loss of connection)
learning theory- depression
Seligman
learned helplessness
depressed bc feel helpless
object loss- depression
renee spitz
loss of signif other during first 6mo of life
(attachment theory)
cognitive theory
aaron beck
depression is cognitive v than affective
negative expectations- environment, self, future
Pt is causing the depression bc they are thinking negatively
major dep. disorder- diagnostic criteria
change in sleeping, eating patterns (dec 5%. body weight in 30 days)
loss of interest in usual activities
s/s must be present for at least 2 weeks
NO hx of manic behavior (bipolar not depression)
s/s represent a change from baseline functioning
major d d- s/s criteria
sad, lack of interest 2 wks or more and at least 4 other symptoms
changing in eating habits
hypersomnia/insomnia
impaired concentration, decision making/problem solving
worthlessness, hopelessness, despair
thoughts of death/fatigue
overwhelming fatigue, negative thinking
persistent depressive disorder v MDD
s/s more mild
no evidence of psychotic s/s
not suicidal
depressed for most of the day, more days than not
present for at least 2 YEARS
premenstrual dysphoric disorder
onset of s/s week b4 start of menses
improve after start menses
s/s present for most cycles the previous yr
lethargy, diff concentrating, anxiety, irritabitli, depressed mood, change in sleep/eating
s/s must interfere w/ ability to function
substance-induced depressive disorder
can be assoc with withdrawal of seizure and HTN meds
childhood depression criteria- s/s based on age
<3- feeding problems, lack of playfulness, tantrums
3-5 - accident prone, phobias, self blame
6-8- aggressive beh, clinging beh, physical complaints
9-12 - morbid thoughts, excessive worrying
childhood depression- trtmnt
precipitated by loss
therapy- alleviate sx and strengthen coping skills
parental/family therapy
adolescent depression- diagnosis/ trtmnt
beh change that lasts for several weeks
results from perception of abandonment (parents or peers)
trtmnt- supportive psychosocial intervene
SSRI
consideration w/ ssri and kids/ adolescents
inc risk of suicidality
senescence- depression trtmnt
antidepressant meds, electroconvulsive therapy, psychosocial therapy
postpartum depresion- trt/ s/s
trt- antidep, psychosocial therapy
s/s- fatigue, dec appetite, sleep disturbances, concern abt inability to care for infant
transient depression
s/s not impair functioning
tired, self blame, crying
mild depression
usually assoc. w/ grieving
affective- anger, anxiety
behavioral- tearful
cognitive- preoccupied w/ loss
physiological- anorexia, insomnia
moderate depression
affective- helpless
behavioral- limited verbalization, slowed movements
cognitive- difficulty concentrating/ critical thinking
physiol- ha, sleep disturbance
severe depression
inc s/s of MDD and bipolar depression
total despair, flat affect
absence of communication
delusional thinking, confusion, suicidal thoughts
general slow down of the body
depression disorders trtmnt
individual psychotherapy (interpersonal realtions_
group therapy
family therapy
cognitive therapy (changing thoughts)
transcranial magnetic stim
light therapy
electroconvulsive therapy (initiate a grand mal seizure)
neuromodulation (deep brain stim and vagal nerve stim)
depression disorders- meds
SSRI
SNRI
MAOI
Tricyclics
ketamine nasal spray
SSRI
ae- dry mouth, dec libido
do not take w/ MAOI- SS
nsaids, warfarin inc lvls
work 4-8 wks
SNRI
dry mouth, dec libido
withdrawal s/s
MAOI, haldol, lithium, tramadol, nsaids, warfarin contraindicated - SS
work 4-8 wks
Noraderenergic -dopaminergic antidepr
ex. wellbutrin
can be used for ADHD or to counteract sexual dysfunction w/ SSRI
ae- dec seizure threshold
contraind w/ MAOI
6-8 wks full effect
heterocyclics
ex. trazadone
ae- urinary retention, priapism
instant onset- works for sleep aid
MAOI contraind
full effect 3-4 wks
tricyclics
2nd or 3rd line agent for MDD
ae- wt gain
*do not prescribe for suicidal pts
OD IS LETHAL (monitor cardiac functioning (wide qrs)
avoid MAOI- SS
clonidine- HTN crisis (used for htn or adhd)
frequent EKG- monitor blood lvls
work 3-4 wks
MAOI
3rd line agent for trtmnt resistant depression
more commonly used for parkinsons (selegiline)
LETHAL OD
HTN crisis w/ tyramine foods, SS
smoked/aged cheese, processed meats, alcohol, chocolate, beef/chicken liver, yeast products, soy beans, diet pills
bipolar def
mood swings from profound depression to extreme mania
can have delusions and hallucinations
s/s can reflect seasonal pattern
hypomania- bipolar
period of abnormal and persistent elevated or irritable mood lasting 4 days
no impaired functioning
no psychotic s/s
bipolar epidemiology
presents in ages 20-30
bipolar 1- timeline
lows at least 2 wks, extreme highs at least 1 wk
or need for hospitalization
can last 3-6mo
bipolar 2- def
bouts of MDD w/ episodic hypomania
NOT meet criteria for full manic episode
lows just as low as BP1 but manic episodes are milder
cyclothymic disorder- criteria
subcat of bipolar
cyclic
mood disturbance
at least 2 yr duration
longest time w/o s/s is 2 mo
many episodes of hypomania and depressed mood
bipolar- biologic theories
has genetic component
GABA disregu
inc noradrenergic activity
ion channel abnormal
kindling (inc severity of responses w/ recurrent exposure to triggers)
bipolar- childhood
inc comorbid w/ ADHD
adhd meds can exacerbate mania
bipolar childhood- trtmnt
lithium, divalproex, atypical antipsychotics
carbamzaepine
family psychoeducation about disorder
communication training
problem-solving skills
bipolar- mania meds
lithium
anitconvulsants (mood stabilizer)
cardiogenic drugs for vascular effect
histmine blockers for tension
antipsychotics
bipolar- depressive phase meds
mood stabilizers
SSRI (with care!!! can trigger mania)
lithium contraindications
nsaids and etoh
need to maintain consistent blood volume lvls
lithium range
0.5-1.2 mEq/L
draw a trough 12 hrs post dose
toxicity dependant upon each person
lithium ae
polyuria, polydipsia, wt gain, sexual dysfunction
lithium lab tests
TSH, PTH, UA, CBC, EKG, Na, Ca, phosphorus
lithium toxicity
ae- n/v, tremor, seizures
trtmnt- IV fluids, whole bowel irrigation
SILENT- lithium
syndrome of irrev lithium effectuated neurotoxcicity
truncal ataxia, scanning speech, incoord
lithium- pt ed
notify dr if diarrhea or vomiting occur
check lvls every 1 to 2 months
maintain consistent diet
don’t skimp on dietary sodium intake
anticonvulsants (mood stabilizer) pt ed
do not discont abruptly
report rash, brusing, sore throat, fever, malaise, dark urine
avoid use of etoh
Ca channel blocker pt ed
take if GI upset occurs
orthostatic hypotension
blurred vision, dizziness, drowsiness
antipsychotics pt ed
use sunscreen
orthostatic hypotension
avoid etoh
report- sore throat, persistent n/v, ha, rapid hr, change in urination, yellow skin, muscular incoordination
suicide-def
BEHAVIOR (not diagnosis or disorder)
15x inc in ppl w/ bipolar or depression vs normal pop
suicide risk factors- marital, age, religion, socioeconomic and ethnicity
martial status (single 2x)
gender (men more successful, women attempt more)
Age (inc risk w/ age, espec men) (white men >80 highest risk)
religion (dec risk if have a religion)
Socioeconomic status (high and low classes greater risk than middle) (higher rates in unemployed) (if employed- dr., dentist, artist, lawyers and insurance agents)
ethnicity (whites have highest risk) then indians, black, hispanic, asian
suicide r/factors- other
substance abuse, mood disorder
(schizo, personality disorder, anxiety, trauma)
insomnia, etoh abuse, psychosis w/ command hallucinations
fam hx of suicide
chronic disease
LGBTQ
physical dependence v psychological dependence
physical- need for inc amnts to produce same effects
psychological- desire to repeat use of a particular drug for pleasure
substance-induced disorder- subst. intoxication
reversible syndrome
s/s after excessive use of substance
direct effect on CNS
social and occupational functioning disturbed
100-200 mg/dl
death at 400-700 mg/dl
substance-induced- withdrawal
s/s after stopping substance
s/s specific to substance used
disrupts beh, thinking and feeling
w/in 4-12 hrs after cessation
monitor for seizures for up to 10 days
give gabapentin
substance abuse- personality factors
low self-esteem
freq depression
inability to relax/defer gratification
inability to communicate
phases of alcoholism
1- prealcoholic- use to relieve everyday stress
2- early alcoholic- blackouts, etoh required
3- crucial phase- no control, physiological dependence
4- chronic phase- (IV)- emotional/physical disintegration
alcoholic myopathy
from vitamin B (thiamine) deficiency
acute- sudden onset muscle pain, weakness, reddish tinge to urine
chronic- graduate wasting of muscles
Wernicke’s encephalopathy
most severe form of thiamine deficiency in alcoholics
ae of alcohol abuse
esophagitis,
gastritis,
cardiomyopathy,
pancreatitis (epigastric pain),
cirrhosis (portal htn, esophageal varicies, ascites, hepatic encephal- cannot covert ammonia to uria),
hepatitis (can cause ascites- use fluid centesis, monitor bp, r/f infection)
ae of alcohol abuse
esophagitis,
gastritis,
cardiomyopathy,
pancreatitis (epigastric pain),
cirrhosis (portal htn, esophageal varicies, ascites, hepatic encephal- cannot covert ammonia to uria),
hepatitis (can cause ascites- use fluid centesis, monitor bp, r/f infection)
alcohol and preg- ae
FASDs fetal alch. spectrum disorders
FAS- fetal alch syndrome
alterations in memory, learning, hearing, vision, communication
s/s- abnormal facial features, sleep and sucking problems, hyperactive beh, poor coordination
etoh withdrawal s/s
tremors, irritability, seizures, hallucinations, delirium
autonomic act is worst in the first 5 days
alcohol assessment tools
drug hx and assessment
CIWA clincial institute w/drawal assessment of etoh scale
cage questionnaire
ciwa
mild, mod or severe
q3h
bp,hr,rr
clonidine for high bp
cage
cut
annoyed
guilty
eye-opener (drink first thing in the morning)
barbiturates, nonbarbit hypnotics, antianxiety and club drugs- priority assessment
CNS depression
respiratory rate
hr
bp
(all are dec)
sedative/ hypnotic affects on the body
respir depression
hypotension
jaundice
dec body temp
rebound insomnia