Exam 2 Flashcards
neoplasm
any new or abnormal cellular growth; specifically one that is uncontrolled and progressive; relatively autonomous growth of tissue (growth is not properly regulated by the normal biochemical and physical influences); refers to benign and malignant tumors
tumor
an abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancer), or malignant (cancer). Also called neoplasm
benign
growth of cells is steady, slow; usually confined; treatable, not fatal but can cause problems. Benign tumors may grow larger but do not spread to other parts of the body. Also called nonmalignant
malignant
cells can invade and destroy nearby tissue and spread to other parts of the body (metastasis); resistant to treatment and frequently fatal. Cancerous
carcinoma
malignant tumor originating in epithelial tissues, like skin or in tissues that line or cover internal organs. (e.g. breast, colon, melanocytes, liver)
sarcoma
malignant tumor originating in connective tissue (bone, muscle, adipose, hematopoietic, lymphoid)
metastasis
the spread of cancer from one part of the body to another
cancer
Disorder of cell growth and regulation
- No limits for cellular replication
- Production of cells that serve no purpose
Malignant neoplasms
What is the 2nd leading cause of mortality?
cancer
carcinogen
Substance which causes cancer
carcinogenesis
Multi-step process in which normal cells are transformed into cancer cells
What are the risk factors for cancer?
Cigarette smoke
Pesticides
Certain food additives (nitrosamines, nitrites)
Polycyclic hydrocarbons (many chemicals: some are produced due to charring protein foods)
Occupational hazards (asbestos)
Aflatoxin B1 (produced by mold that may grow in grains and nuts stored in warm, humid environments)
nitrosamines + sodium nitrate are
added to cured meats to help inhibit the growth of Clostridium botulinum
What can you add to cured meats in production of the product to decrease nitrosamine formation?
ascorbic acid or tocopherol
What happens during radiation?
DNA is damaged beyond repair
Radiation is believed to be a ________________?
initiator
What sources are known to be carcinogenic?
X-rays
UV light (skin cancer)
Radioactive materials
Atomic wastes
What are lifestyle factors that can increase the risk of cancer?
emotional stress
Estrogen-progestin therapy (menopause) increases
breast cancer risk
Estrogen therapy (ET) for menopause increases
endometrial cancer risk
Oral contraceptives _____________ the risk of endometrial and ovarian cancers, but ____________ the risk of breast, cervical, and liver cancers
decrease, increase