exam 2 Flashcards
what does damaged tissues release in the extrinsic clotting mechanism
tissue thromboplastin (factor iii)
what does prothrombin activator do
converts prothrombin to thrombin
what enzyme catalyzes a reaction that converts fibrinogen to fibrin
thrombin
how does blood flow prevent blot clots
rapidly carries excess thrombin away and keeping its concentration low to prevent excess clotting
what substance initiates the intrinsic clotting mechanism
hageman factor (factor xii)
when factor x (stuart prower) is activated in both the extrinsic and intrinsic mechanism, they follow the same path of coagulation, this is known as…
common pathway
order of blood coagulation in the intrinsic mechanism
blood contacts foreign surface ➡️ hageman factor ➡️ prothrombin activator ➡️ prothrombin to thrombin ➡️ fibrinogen to fibrin
order of blood coagulation in extrinsic clotting mechanism
damage to tissue or vessel ➡️ tissue thromboplastin ➡️ prothrombin activator ➡️ prothrombin to thrombin ➡️ fibrinogen to fibrin
how are blood clots dissolved
fibrin threads absorb plasminogen, then plasminogen activator is released from the lysosomes to convert plasminogen to plasmin, plasmin digest fibrin threads
what is the von willebrand factor
plasma protein that facilitates the binding of platelets to one another
location of right coronary artery
passes along atrioventricular sulcus between right atrium and right ventricle
two branches of the right coronary artery and their locations
posterior interventricular artery: travels along posterior interventricular sulcus and supplies posterior walls of both ventricles
right marginal branch: passes along lower border of heart to supply right atrium and right ventricle
two branches of the left coronary artery and their locations
circumflex branch: follows atrioventricular sulcus between left atrium and left ventricle to supply blood to left atrium and ventricle
anterior interventricular artery: lies anterior to interventricular sulcus and supplies both ventricles
location of coronary sinus
posterior atrioventricular sulcus
most abundant and least abundant leukocytes
most: neutrophils
least: basophils
what does the formed elements in the blood arise from
hematopoietic stem cells/hemocytoblasts
what myeloid stem cells does granulocytes arise from
myeloblast
what myeloid stem cell does platelets/thrombocytes arise from
megakaryoblast
what myeloid stem cell does rbcs arise from
erythroblast
what stem cells do agranulocytes arise from
monocytes: myloid stem cells called monoblasts
lymphocytes: lymphoid stem cells called lymphoblasts
rbc counts for males and females
males: 4700000-6100000
females: 4200000-5400000
define polycythemia
excessive rbcs
define hemolytic anemia
decreased rbcs caused by bacterial infections or failed blood transfusion
define pernicious anemia
decreased rbcs caused by not enough intrinsic factor to absorb b12
define aplastic anemia
decreased rbcs by destruction of red bone marrow
define iron deficiency anemia
decreased hemoglobin due to dietary malnourishment or menstruation
define thalassemia
abnormal hemoglobin caused by rbcs being short lived from a gene
what colors do neutrophils appear and how many lobes
light purple to pink and has many lobes
what leukocytes are also called polymorphonuclear leukocytes
neutrophils
what colors do eosinophils appear and how many lobes
deep red and two lobes
what color does basophils appear and how many lobes
deep blue and many granules
what color does monocytes appear and what is shape of nuclei
light purple with kidney or bean shaped nuclei
what color does lymphocytes appear and what is shape of nuclei
deep purple and spherical nucleus
normal wbc count
3500-10500/mL
leukocytosis vs. leukopenia
leukocytosis: excess wbc
leukopenia: low wbc
what does thromboxane a2 do
chemical released by platelets that stimulates aggregation
thombocytosis vs. thrombocytopenia
thrombocytosis: high platelet
thrombocytopenia: low platelet
normal platelet counts
150000 to 4000000