Exam Flashcards
- Which of the following is a true statement for viruses?
a. Enveloped viruses include ribosomes
b. A viral envelope only includes virus encoded proteins
c. The viral genome can be either RNA or DNA
d. Their capsomeres are made up of capsid subunits
e. They typically have spherical shapes because it is the most stable biological morphology
c. The viral genome can be either RNA or DNA
- Which of the following viruses has a distinctive stellate nucleocapsid morphology?
a. Alphavirus
b. Adenovirus
c. Arenavirus
d. Astrovirus
e. Coronavirus
d. Astrovirus
- An envelope is found in which of the following viruses?
a. Influenzavirus
b. Papillomavirus
c. Parvovirus
d. Adenovirus
e. Circovirus
a. Influenzavirus
- A single Streptococcus is approximately how many times larger than the smallest virus pathogens (Parvovirus and Circovirus)?
a. 10 times
b. 20 times
c. 50 times
d. 500 times
e. 1000 times
Answer is 100 ish (c)
- Viral haemagglutination is a feature of which phenomenon?
a. Virus-antibody complexes binding to complement receptors on erythrocytes.
b. Virus attachment proteins binding to erythrocyte surface antigens.
c. Membrane attack complexes triggered by virally induced complement activation.
d. Toll-like receptors non-specifically reacting to virus envelope proteins.
e. Viral induced fusion of erythrocyte cytoplasmic membranes.
b. Virus attachment proteins binding to erythrocyte surface antigens.
- Which of the following are recognised characteristics of prion proteins?
a. They are resistant to formalin.
b. They are inactivated by autoclaving.
c. They are susceptible to proteases.
d. Their alpha-helix morphology gives them their strength.
e. The genetic origins are transmissible.
A
- Which of the following diseases is caused by a virus?
a. Kuru
b. Scrapie
c. Creutzfeld-Jakob Disease (CJD)
d. Canine Distemper
e. Bovine Spongiform Encephalopathy (BSE)
d. Canine Distemper
- Which of the following viruses is more likely to cause intranuclear inclusions?
a. Adenovirus
b. Picornavirus
c. Paramyxovirus
d. Reovirus
e. Calicivirus
a. Adenovirus
DS DNA enveloped
- Influenzaviruses have which following characteristics?
a. They are non-enveloped
b. They have a genome of positive sense RNA
c. They carry viral-encoded RNA-dependent RNA polymerase in the virion.
d. They use reverse transcriptase to replicate.
e. They replicate in the nucleus.
e and c
- Which of the following is correct for Retrovirus replication?
a. The viral genome is inserted into the host DNA via the action of integrase.
b. Reverse transcriptase first makes an RNA strand copy of the viral genome following uncoating.
c. The virion must carry its own RNA-dependent RNA polymerase
d. Viral encoded protease cuts the host DNA for virus genome insertion.
e. The insertion of viral genome in host DNA is site specific.
a. The viral genome is inserted into the host DNA via the action of integrase.
- Which of the following is an example of a severe disease caused by spillover into an aberrant host?
a. Malignant catarrhal fever caused by Ovine herpesvirus-2
b. Rabies
c. A cockatoo with psittacine beak and feather disease
d. Swine flu
e. Mucosal Disease in cattle
a
- Which of the following events is most likely to occur in a bovine foetus infected transplacentally at age 200 days gestation?
a. Seroconversion
b. Persistent infection and immunotolerance
c. Abortion
d. Congenital anomalies
e. Mucosal disease later in life
A
- Which of the following is a recognised viral mechanism of neoplasia?
a. Papillomavirus E7 protein preventing apoptosis by inactivating P53.
b. The MEQ gene of Marek’s disease virus mimics transcription factors that activate cell replicaiton.
c. Insertional mutagenesis due to herpesvirus infection.
d. Slowly-transforming retrovirus genome random insertion inside or near a tumour suppressor gene.
e. Papillomavirus E7 protein inactivating cellular proto-oncogenes.
B
- Hemagglutinins of Influenzavirus:
a. bind to sialic acid on the surface of epithelial cells which leads to viral entry via endocytosis
b. are nucleocapsid proteins used for host attachment.
c. are enzymes within the envelope that degrade sialic acid in cell membranes.
d. breakdown cell membranes
e. bind non-specifically to all erythrocytes.
A
- Antigenic shift:
a. occurs when two different strains of the same virus combine to form a new virus that has a mixture of genes from the original viruses.
b. can arise from a spontaneous point mutation of individual nucleic acid bases in the viral genome.
c. cannot occur as a result of recombination.
d. only occurs in RNA viruses (such as Rotavirus).
e. is the way canine parvovirus came into existence.
a. occurs when two different strains of the same virus combine to form a new virus that has a mixture of genes from the original viruses.
- Foot-and-Mouth Disease virus:
a. replicates in and lyses epithelial cells of the stratum spongiosum of stratified squamous mucosa and skin and results in formation of vesicles
b. is more common in sheep and goats compared to cattle and pigs.
c. never uses leukocyte trafficking to spread systemically
d. is caused by Vesiculovirus, an enveloped RNA virus
e. is a major cause of economic loss in Australian beef herds.
a. replicates in and lyses epithelial cells of the stratum spongiosum of stratified squamous mucosa and skin and results in formation of vesicles
- Parvovirus:
a. involves infection of mitotically active cells because it requires a target cell-derived duplex transcription template (only available during S phase).
b. is a genus of enveloped DNA viruses that cause lysis of crypt epithelial cells and lymphocytes.
c. is able to turn on DNA synthesis in target cells
d. infection in the dog requires capsid proteins to bind to neuraminic acid and transferrin receptors on the target cell
e. causes similar disease to canine enteric coronavirus but is less severe
a. involves infection of mitotically active cells because it requires a target cell-derived duplex transcription template (only available during S phase).
- IgE mediated degranulation of mast cells is a key effector mechanism of which of the following inflammatory events?
a. Type I hypersensitivity
b. Delayed type hypersensitivity
c. Drug induced anaphylaxis
d. Type II hypersensitivity
e. Type III hypersensitivity
A
- Preformed intracytoplasmic granules present within mast cells contain:
a. histamine, heparin and tryptase.
b. leukotriene-D4 and prostaglandin-D2
c. TNF-alpha and IL-4
d. epinephrine and eotaxin.
e. chemokines and platelet activating factor (PAF)
A
- Desensitisation to Type I hypersensitivity involves which of the following mechanisms?
a. Stimulation of dendritic cells as the dominant antigen presenting cell (APC).
b. Activation of macrophages to produce IL-12 and present antigens to CD4 lymphocytes.
c. Production of IL-5 by CD4 TH2 lymphocytes.
d. Corticosterone induced suppression of CD4 lymphocytes.
e. Exclusion of the antigen from the diet or environment
b. Activation of macrophages to produce IL-12 and present antigens to CD4 lymphocytes.
- Which of the following is a characteristic of Type II hypersensitivity?
a. It is the main mechanism for most allergic skin diseases.
b. It is also known as antibody dependent cytotoxicity.
c. It involves exposure to milligrams amounts of foreign antigen(s).
d. It involves activation of complement via the alternate pathway.
e. It is usually triggered by exposure to environmental haptens or antigens
b. It is also known as antibody dependent cytotoxicity.
- Which of the following is an example of a Type IV hypersensitivity?
a. Myasthenia gravis.
b. Pemphigus foliaceus.
c. Neonatal isoerythrolysis
d. Tuberculin reaction
e. Glomerulonephritis
d. Tuberculin reaction
- In older animals which of the following is a recognised feature of immunosenescence?
a. There is a random deletion of CD4 lymphocytes
b. Phagocytes increase in number to counteract a decline in lymphocytes.
c. Response to vaccination is usually still strong.
d. There is an increase in CD4:CD8 lymphocyte ratio
e. There is diminished self-renewal capacity of haematopoietic stem cells.
e. There is diminished self-renewal capacity of haematopoietic stem cells.
- Severe Combined Immune Deficiency (SCID) in Arabian foals has which of the following features?
a. There is partial failure of adaptive immune responses.
b. Antibody response is retained.
c. Defective Ig gene results in loss of B and T cell receptors.
d. They can be diagnosed at age 1 week by measuring plasma IgG.
e. Haematology at 1 week of age reveals an absence of circulating lymphocytes (absolute lymphocytopaenia).
c. Defective Ig gene results in loss of B and T cell receptors.
- Chédiak-Higashi Syndrome results in:
a. Normal CD8+ cytotoxicity & NK functions but impaired B-cells.
b. Failure of phagolysosome formation in neutrophils and macrophages.
c. Failure of phagocytosis by neutrophils.
d. Normal circulating neutrophil numbers but abnormal neutrophil granules.
e. A defective adaptive immune system due to a defective immunoglobin gene.
B
- Which of the following is the most common pathological mechanism of myasthenia gravis?
a. Type II hypersensitivity directed against nicotinic acetylcholine receptors.
b. Type II hypersensitivity to presynaptic muscarinic acetylcholine choline receptors of somatic neurons.
c. Type I hypersensitivity to sarcolemmal nicotinic acetylocholine receptors.
d. Immunoglobulin M directed against sarcolemmal acetylcholine receptors.
a. Type II hypersensitivity directed against nicotinic acetylcholine receptors.
- Which of the following protects spermatozoa from autoimmune attack in the testis?
a. High background levels of IL-1a, Il-6 and TGF-? and Activin-A in the testis.
b. Immune tolerance generated by Hassall’s corpuscles during thymus development.
c. Low expression of MHC-I by spermatogonia.
d. Down-regulation of IL-17 by spermatogonia and spermatocytes.
a. High background levels of IL-1a, Il-6 and TGF-b and Activin-A in the testis.