Exam 1 Random Flashcards
Which drug/drug class causes the greatest amnesia?
Benzo > Ketamine
Which drugs cause myoclonic activity?
- Methohexitol
- Ketamine
- Etomidate
- Propofol
- Meperidine (active metabolite Normeperidine)
Which drugs increase ICP?
- Ketamine
- Midazolam w/rapid injection
- Fentanyl & Alfentanil
Which drugs decrease ICP?
- Barbs
- Propofol
- Etomidate
- Opiods (unless hypovent)
Which drug cause enzyme induction?
- Barbs
- Ketamine (w/chronic administration)
Which drugs are good for asthmatics?
Barbs (TPL)
Which drugs are bad for asthmatics?
- Ketamine
- Propofol (preservatives)
- Meperidine
- Morphine
Which drugs are cerebroprotective?
Barbs & propofol
Which drugs potentiate NMB?
Etomidate & ketamine
Which drugs do you need to give slowly?
- Midazolam (inc ICP)
- Fospropofol
- Barbs (histamine release)
- Opiods (resp dep)
Which drugs have HIGH hepatic extraction ratios (perfusion dependent elimination)?
- Ketamine
- Methohexitol
- Etomidate
Which drugs have LOW hepatic extraction ratios (depend only on hepatic enzymes)?
- TPL
Which drugs have active metabolites?
Diazepam = Desmethyldiazepam (E1/2t = 48-96hrs) Midazolam = 1-hydroxymidazolam Ketamine = Norketamine (20-25% of parent drug)
Morphine = Morphine-6-glucuronide (650x more potent) Meperidine = Normeperidine (1/2 as potent, lasts 3 days) Fentanyl = Norfentanyl (3 weak metabolites) Sufentanil = Desmethsufentanil (weak, 1/10 as potent) Alfentanil = Noralfentanil
Which drug is a pro-drug?
Fospropofol
Which drugs cause histamine release?
TPL
Meperidiine
Morphine
Which drugs do we avoid in porphyria?
TPL, Thiamylal, Methohexitol
Etomidate
Which drugs are WATER soluble in solution?
- Dexmedetomidine
- Midazolam
- Ketamine
- Fospropofol
Which drugs are LIPID soluble?
- Etomidate
- Propofol
- Diazepam
- Lorazepam
- Barbs
Which drugs decrease the slope of the ventilatory response curve?
-Benzos
-Propofol
(Compensating but taking longer)
Which drug shifts the vent response curve to the RIGHT?
Opiods (blunt response to CO2)
Which drugs produce isoelectric EEG?
Propofol & Barbs
Which drugs cause DIRECT CARDIAC DEPRESSION?
- Ketamine
- Meperidine
- Propofol (dose dep)
- Barbs (minimal due to inc HR)
Drugs that cause N/V?
Etomidate & Opiods
Drugs that tx N/V?
Propofol
Which drugs cause sphincter of oddi spasms?
Opiods (Morphine, Alfentanil, Remifentanil)
Which drugs tx sphincter of oddi spasms?
Nubain, Narcan, Gucagon & NTG
Which drugs cause paradoxical excitement?
Benzos & barbs
Which two drugs cause wooden chest & plum first pass effect?
Fentanyl & sufentanil
Peds dosing (dec dose vs inc dose)
DECREASE Opiod dose
INCREASE TPL dose
Which drugs do you avoid in pts taking MAOIs?
MAOI = avoid Ketamine, Morphine & Meperidine
