Exam 1 pharm Flashcards

1
Q

Chlorhexidine

A

broad spectrum antrimicrobial widely used in hospitals

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2
Q

becaplermin

A

Platelet derived growth factor used to treat diabetic foot ulcers
risk of malignancy if over 4 tubes used

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3
Q

miconazole
clotrimazole
efinaconazole
ketoconazole

A

topical imidazoles used to treat skin infections

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4
Q

nystatin

amphotericin B

A

alters membrane permability

treats candida infections

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5
Q

capsaicin

A

used for pruritus

acts on TRPV1 channels and wears them out causing desensitization

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6
Q

mirtazapine

A

nocturnal pruritus

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7
Q

sertraline

A

cholestatic pruritus

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8
Q

naltrexone

A

cholestatic and CKD pruritus

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9
Q

butorphanol

A

nocturnala nd intractable pruritus

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10
Q

gabapentin

pregabalin

A

neuropathic pruritus

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11
Q

oxymetazoline

A

α-agonist cream for rosacea

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12
Q

Treatment course for acne

A

Mild comedonal → topical retinoid
Mild Papular/pustular → topical retinoid + topical antimicrobial
Moderate papular/pustular → topical retinoid + oral antibiotic + BPO
Moderate nodular → topical retinoid + oral antibiotic + BPO
Severe nodular → oral isoretinoin

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13
Q

Tretinoin

A

topical retinoid used for acne
activated DNA upregulation of RARE which
reduces follicular occlusion and microcomedone formation

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14
Q

Benzoyl peroxide
clindamycin
erythromycin

A

topical antimicrobial fo acne

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15
Q
Tetracycline
doxycycline
minocycline
erythromycin
azithromycin
trimethoprim
A

Oral antibiotics used in acne

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16
Q

apremilast

A
psoriasis
PDE4 inhibitor 
↓ NOS, TNF-α
↑ IL-10
oral
17
Q

ustekinumab

A

psoriasis

↓ IL-12, IL-23

18
Q

secukinumab

A

psoriasis

↓ IL-17

19
Q

minoxidil

A

baldness

K+ channel opening → vasodilation

20
Q

hydroxyurea

A

Treatment for sickle cell

↑ fetal hemoglobin production

21
Q

eculizumab

A

Treatment for PNH

↓ complement attack on RBCs

22
Q

(Peg)Filgrastim

A

Recombinant G-CSF
offsets bone marrow suppression of chemo
(peg) is longer acting

23
Q

sargrmostim

A

recombinant GM-CSF
↑ neutrophils, eosinophils, monocytes/macrophages
used after bone marrow transplant

24
Q

oprelvekin

A

recombinant IL-11

25
Q

Romiplostim and eltrombopag

A

↑ platelet production