Exam 1 pharm

Question 1

Chlorhexidine

Answer 1

broad spectrum antrimicrobial widely used in hospitals

Question 2

becaplermin

Answer 2

Platelet derived growth factor used to treat diabetic foot ulcers
risk of malignancy if over 4 tubes used

Question 3

miconazole
clotrimazole
efinaconazole
ketoconazole

Answer 3

topical imidazoles used to treat skin infections

Question 4

nystatin

amphotericin B

Answer 4

alters membrane permability

treats candida infections

Question 5

capsaicin

Answer 5

used for pruritus

acts on TRPV1 channels and wears them out causing desensitization

Question 6

mirtazapine

Answer 6

nocturnal pruritus

Question 7

sertraline

Answer 7

cholestatic pruritus

Question 8

naltrexone

Answer 8

cholestatic and CKD pruritus

Question 9

butorphanol

Answer 9

nocturnala nd intractable pruritus

Question 10

gabapentin

pregabalin

Answer 10

neuropathic pruritus

Question 11

oxymetazoline

Answer 11

α-agonist cream for rosacea

Question 12

Treatment course for acne

Answer 12

Mild comedonal → topical retinoid
Mild Papular/pustular → topical retinoid + topical antimicrobial
Moderate papular/pustular → topical retinoid + oral antibiotic + BPO
Moderate nodular → topical retinoid + oral antibiotic + BPO
Severe nodular → oral isoretinoin

Question 13

Tretinoin

Answer 13

topical retinoid used for acne
activated DNA upregulation of RARE which
reduces follicular occlusion and microcomedone formation

Question 14

Benzoyl peroxide
clindamycin
erythromycin

Answer 14

topical antimicrobial fo acne

Question 15

Tetracycline
doxycycline
minocycline
erythromycin
azithromycin
trimethoprim

Answer 15

Oral antibiotics used in acne

Question 16

apremilast

Answer 16

psoriasis
PDE4 inhibitor 
↓ NOS, TNF-α
↑ IL-10
oral

Question 17

ustekinumab

Answer 17

psoriasis

↓ IL-12, IL-23

Question 18

secukinumab

Answer 18

psoriasis

↓ IL-17

Question 19

minoxidil

Answer 19

baldness

K+ channel opening → vasodilation

Question 20

hydroxyurea

Answer 20

Treatment for sickle cell

↑ fetal hemoglobin production

Question 21

eculizumab

Answer 21

Treatment for PNH

↓ complement attack on RBCs

Question 22

(Peg)Filgrastim

Answer 22

Recombinant G-CSF
offsets bone marrow suppression of chemo
(peg) is longer acting

Question 23

sargrmostim

Answer 23

recombinant GM-CSF
↑ neutrophils, eosinophils, monocytes/macrophages
used after bone marrow transplant

Question 24

oprelvekin

Answer 24

recombinant IL-11

Question 25

Romiplostim and eltrombopag

Answer 25

↑ platelet production