Exam 1: Peptic Ulcer Disease (PUD) Flashcards
What is Peptic Ulcer Disease ?
Erosion of GI mucosa (gastric or duodenal)
It can be in the stomach or duodenum !!
What type of PUD tends to be more superficial/irritation ?
Acute
What type of PUD tends to be deeper/ through muscle ?
Chronic
Acute vs. Chronic PUD, depends on what ?
depends on mucosal involvement
What are causes of PUD ?
- Infection (Helicobacter Pylori)
- Drugs (ASA, steroids, NSAIDS, smoking
What are manifestations of PUD ?
- Nausea
- Heart burn
- Pain relieved with antacids or eating (duodenal)
- Gnawing or burning epigastric pain
With GASTRIC Peptic Ulcers, the Gnawing or burning epigastric pain occurs how long after eating ?
1-2 hours
With DUODENAL peptic ulcers, the gnawing or burning epigastric pain occurs how long after eating ?
2-4 hours
How does Asparin (ASA) cause PUD ?
Directly irritates the lining
How do Steroids cause PUD ?
They reduce the integrity of the lining by preventing cell renewal
- They reduce protective mechanisms of the mucosa
_________ & _______ Go Together! ?
hint: what 2 kinds of drug classes
Steroids & PPI”s
- If we see pt’s on steroids (ex: prednisone), they will most likely also be on a PPI (ex: pantoprazole)
What are complications of PUD ?
- Hemorrhage
- Perforation
- Gastric outlet obstruction
What are manifestations of hemorrhage ?
- Melena, occult blood in stool (black/tarry stool)
- Obvious bleeding
- Coffee-ground vomitus
- Tachycardia
- Thready pulse
- Fatigue
- Weakness
- Dizziness
- Orthostatic Hypotension
- Syncope
- Decreased H & H
Manifestions d/t hemorrhaging into larger blood vessels
Hemorrhage cause what ?
Low blood/ fluid volume
What are manifestations of perforation ?
- Severe upper abdominal pain radiating to the shoulder
- Rigid, board-like abdomen
- Absence of bowel sounds
- Diaphoresis
- Tachycardia
- Rapid shallow respirations
- Fever (b/c stomach contents have left the GI tract and invaded the peritoneal space)
What is the general Tx for perforations ?
- IV lactated ringers
- IV albumin (protein) (to restore fluid by pulling fluid into the bloodstream) (*Albumin causes a fluid shift)
- Packed RBC’s
- Some type of surgical intervention (to repair the perforated bowel)