Exam 1: Pathology of Bone Flashcards
which is the most vascularized portion of the bone?
the metaphysic which is the primary foci for hematogenous spread to the bone in regards to osteomyelitis
How many types of Osteogenesis Imperfecta are there?
…
What is the most common type of Osteogenesis Imperfecta?
type 1
Which form of Osteogenesis Imperfecta is the most fatal?
type 2; often autosomal recessive
In addition to the multiple fractures, blue sclera is seen in each of the forms of Osteogenesis Imperfecta EXCEPT in?
Type 4
which two diseases are associated with osteosclerotic thickening of the bones?
Osteopetrosis and Paget’s disease
What occurs in osteopetrosis?
…
Symptoms of osteopetrosis
- cranial nerve compression leading to deafness, blindless and facial paralysis
- -pancytopenia as a result of the medullary cavity in the bone
Which two bone disorders are associated with Vitamin D deficiency with resulting failure to mineralize the osteoid?
Osteomalacia and Rickets
Failure to mineralize the osteoid resulting in an abundance of osteoid manifests as ______ ______ seams
wide osteoid seams
What is the consequence of early development of degenerate osteoarthritis?
decreased cartilaginous proteoglycans and increased water
What is a pannus?
inflammatory synovitis
Is the early development of degenerative osteoarthritis associated with pannus?
NO
What 3 findings are associated with degenerative osteoarthritis?
- Heberden nodes
- osteophyte
- joint mices
What is the most common malignancy of the bone?
metastic ( lung, prostate, breast, kidney)
