Exam 1 - Mycology Chemotherapy

Question 1

Which are the compounds that inhibit DNA functioning?

Answer 1

• Flucytosine
• Griseofulvin
• Pentamidine isethionate

Question 2

Which are the compounds that change membrane permeability?

Answer 2

• Amphotericin B
• Nystatin
• AZOLEs
• Terbinafine

Question 3

Flucytosine

Answer 3

Interferes with pyrimidine metabolism and inhibits both RNA and DNA synthesis.

Question 4

Griseofulvin

Answer 4

Inhibits fungal cell mitosis at metaphase by interaction with microtubules resulting in disruption of mitotic spindles

Question 5

Pentamidine isethionate

Answer 5

Interferes with nuclear metabolism by inhibition of DNA, RNA, phospholipids and protein synthesis

Question 6

Amphotericin B and Nystatin

Answer 6

Deplete ergosterol in fungal cytoplasmic membranes increasing membrane permeability

Question 7

AZOLES:

Fluconazole, itraconazole, ketoconazole, miconazole and thiabendazole

Answer 7

Inhibit ergosterol synthesis by preventing conversion of lanosterol to ergosterol in the cytoplasmic membrane resulting in loss of cell membrane integrity

Question 8

Terbinafine

Answer 8

Fungicidal toxicity is due to the toxic accumulation of squalene that depletes ergosterol in the cell membrane.