Exam 1 Lecture Questions Flashcards
Which hormone is produced in pituitary gland?
LH
Estrogen Receptors primarily binds estrogen where in the cell?
in the cytoplasm
What enzyme converts androstenedione to estrone?
CYP19 (aromatase)
A 6 month old boy is determined to have systemic malignancy originating from precursor cells of the nervous system. The pathology report would state?
neuroblastoma
Which of the following is potentially true of a tumor suppressor gene?
- allows unrestricted cell growth and proliferation
- promotes different phases of cell cycle
- produces proteins that block activity of cyclins
- is often overexpressed in cancer
C
Which phase of the cell cycle would be targeted by Palbociclib (CDK4/6 inhibitor)
G1
A chemotherapy that interferes with DNA synthesis is what phase-specific?
S-phase specific
What is the most common reason for resistance to multiple chemotherapies at once?
- decreased activation of prodrugs
- drug transport out of cells
- cell cycle changes
- mutations in drug targets
Drug transport out of cells
What is unique about the action of Tamoxifen as compared to Fluvestrant?
Activates ER in bone
Which is not hormone responsive cancer type?
- breast
- ovarian
- prostate
- endometrial
ovarian
Which of the following is only in postmenopausal setting?
- letrozole
- tamoxifen
- leuprolide
- raloxifene
letrozole
Which compound acts directly on AR?
- leuprolide
- abiraterone
- degarelix
- enzalutamide
Enzalutamide
Which amino acid is not a target of phosphorylation?
- tyrosine
- serine
- threonine
- alanine
alanine - because of its methyl group side chain
What is the source of the phosphate that gets transferred onto a substrate by a kinase?
- SAM
- DNA
- RNA
- ATP
ATP
What mutation in EGFR confers resistance to 1st and 2nd generation EGFR inhibitors?
- L858R
- Exon 19 deletion
- Exon 14 deletion
- T790M
T790M
