Exam 1--Introduction Flashcards

1
Q

What is the focus of pharmaceutics II?

A

The design and development of various SAFE and STABLE dosage forms or drug delivery systems.

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2
Q

When a patient receives a medication, what is always done?

A

It is always administered through a dosage form or a drug delivery system.

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3
Q

What type of relationship is shown by a zero order process?

A

Non-linear.

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4
Q

What type of relationship is shown by a first order process?

A

Linear

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5
Q

What determines the expiration date of a drug?

A

The physical-chemical stability of the drug.

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6
Q

What is the most common expiration date?

A

2 years

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7
Q

What does flow depend on? What dosage form is it important in?

A
  • Viscosity

* Important in liquid dosage forms

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8
Q

What are some examples of surface phenomenon?

A
  • adsorption
  • hygroscopicity
  • surface tension
  • interfacial tension
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9
Q

What are some examples of colligative properties?

A
  • vapor pressure
  • freezing point
  • osmotic pressure

(role in isotonic solutions, calculation of osmolarity, and mEq)

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10
Q

What is considered to be a conventional solid dosage form?

A
  • tablets that are immediate release (IR).
  • powder as a dosage form
  • hard and soft gelatin capsules
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11
Q

What two categories are solid dosage forms divided into?

A
  • conventional solid dosage forms

* modified release or controlled release dosage forms

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12
Q

Describe a solution.

A

One phase, liquid, clear, and transparent.

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13
Q

Describe a suspension.

A

Two phases, powder is dispersed uniformly into a liquid medium.

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14
Q

Describe an emulsion.

A

Two phases (oil phase and aqueous phase), dispersed uniformly.

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15
Q

If you have a dosage form that contains an aqueous phase, what should you consider adding to it and why?

A
  • preservatives

* without it, the dosage form can contain bacteria

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16
Q

What are semi-solid dosage forms?

A

They are between liquid and solid states.

17
Q

Why are semi-solid dosage forms used? Where are they used?

A
  • applied topically

* have local and systemic effects

18
Q

What is included in semi-solid dosage forms?

A
  • lotions
  • ointments
  • creams
  • paste
  • suppositories
  • transdermal patches
  • injectable
  • inhalers/aerosols
19
Q

List the viscosity of the following from most viscous to least viscous.

Cream, paste, ointment, lotion.

A
  • paste (highest percentage of active ingredient)
  • cream
  • ointment
  • lotion
20
Q

What is special about transdermal dosage form packaging?

A

It lists the strength versus time (mg/hour)

21
Q

What does USP mean?

A

United States Pharmacopeia

22
Q

What will influence the lipophilicity of a therapeutic agent?

A
  • molecular weight

* substituent groups

23
Q

What can be used to improve the aqueous solubility of a drug?

A
  • use of a co-solvent
  • prepare as a suitable salt
  • adjust the pH of a solution
24
Q

What type of drug is available as sodium and potassium salts, and is more soluble at a higher pH?

A

Weak acidic drugs

25
Q

What type of drug is available in an unionized form at low pH, making it better absorbed at the region of low pH?

A

Weak acidic drugs

26
Q

What type of drug is losartan potassium, penicillin VK, and aspirin?

A

Weak acidic drugs