Exam #1 Info Flashcards
1
Q
What is occurring with metabolism?
A
The combustion of glucose with O2 to make CO2 and H2O
2
Q
Why do we need ATP?
A
- Use it to drive conformational changes of proteins ( usually at the 3 or 4th degree level)
- Can stabilize a certain conformation
- Activate electrophiles
3
Q
To be a goo electrophile, it needs a __________.
A
Good leaving group
4
Q
C6H12O6 + 2 ADP + 2 Pi + 2 NAD+ –> 2 pyruvate + 2 ATP + 2 NADH + 2 H2O
A
Glycolysis (substrate-level phosphorylation)
5
Q
The more stable a molecule is, this means __________ are possible.
A
more arrangements
6
Q
Glycolysis Stage 1
A
- Preparatory Stage
- C6 become 2 C3 molecules (through isomerization) with phosphate groups
- Retro-Aldol Reaction
7
Q
What is a retro-aldol reaction?
A
The mixing of two ketones or aldehydes to give a beta-hydroxycarbonyl
8
Q
During stage 1 of glycolysis, there is a break between the ______ and ______ carbons. The reaction is ______.
A
alpha & beta ; reversible
9
Q
Stage 2 of Glycolysis
A
- ATP is generated from “higher energy” compounds
- Done through substrate level phosphorylation
10
Q
Net Generation of Glycolysis of 1 glucose
A
2 ATP, 2 NADH
