Exam 1 - Holmes' drugs/toxins

Question 1

Digoxin

Answer 1

inhibit Na/K pump, increase contractility of heart

Question 2

Oubain

Answer 2

inhibit Na/K pump, increase contractility of heart

Question 3

Palytoxin

Answer 3

binds and locks open Na/K pump

Question 4

Halothane

Answer 4

gaseous anesthetic activates K channels

Question 5

Isoflurane

Answer 5

gaseous anesthetic activates K channels

Question 6

EtOH

Answer 6

inc conductance of GABA channels, anesthetic

Question 7

Lidocaine/Procaine

Answer 7

local anesthetics, block Na channels

Question 8

Phenytoin

Answer 8

anticonvulsant, inhibits Na channels

Question 9

Carbamazepime

Answer 9

anticonvulsant, inhibits Na channels

Question 10

Dofetilide

Answer 10

antiarrhythmic, blocks delayed rectifier Kv channels

Question 11

Tertrodotoxin

Answer 11

blocks Na channel

Question 12

Saxitoxin

Answer 12

blocks Na channel

Question 13

Propofol

Answer 13

blocks Nav channels

Question 14

Neostigmine

Answer 14

blocks AChE, tx for MG

Question 15

hemicholinium

Answer 15

blocks choline re-uptake

Question 16

curare

Answer 16

nAChR antagonist

Question 17

Pyrostigmine

Answer 17

blocks AChE, tx for MG

Question 18

sarin

Answer 18

blocks AChE

Question 19

botulinum toxin

Answer 19

blocks binding of vesicle

Question 20

hexamethonium

Answer 20

nAChR antagonist

Question 21

pancuronium

Answer 21

nAChR antagonist

Question 22

nicotine

Answer 22

nAChR agonist