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Dosage Forms II > Exam 1 Flashcards > Flashcards

Exam 1 Flashcards

Liquid Dosage Forms Cards

1
Q

Sucrose

A

Sweetening agent

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2
Q

Sorbitol

A

Sweetening agent

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3
Q

Citric Acid

A

Buffering, antioxidant, chelating agent

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3
Q

Phosphoric Acid

A

Buffering agent

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4
Q

Ethanol

A

Preservative (alcohol), also co-solvent

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5
Q

Benzyl alcohol

A

Preservative (alcohol)

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6
Q

Chlorobutanol

A

Preservative (alcohol)

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7
Q

Benzoic acid

A

Preservative (acid)

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8
Q

Sorbic acid

A

Preservative (acid)

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9
Q

PARABENS

A

Preservative (paraben)

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10
Q

Benzalkonium chloride

A

Preservative (quaternary compound)

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11
Q

Cetyltrimethylammonium chloride

A

Preservative (quaternary compound)

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12
Q

Water

A

Solvent

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13
Q

Vegetable Oils

A

Solvent

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14
Q

Glycerin

A

Co-solvent

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15
Q

Propylene glycol

A

Co-solvent

16
Q

Gallic Acid

A

Antioxidant (free-radical scavenger)

17
Q

Butylated hydroxyanisole (BHA)

A

Antioxidant (free-radical scavenger)

18
Q

Butylated hydroxytoluene (BHT)

A

Antioxidant (free-radical scavenger)

19
Q

Tocopherol; Vitamin E

A

Antioxidant (free-radical scavenger)

20
Q

Sodium Bisulfite

A

Antioxidant (Reducing agent)

21
Q

Ascorbic acid

A

Antioxidant (Reducing agent)

22
Q

EDTA

A

Antioxidant (Chelating agent)

23
Q

Citric acid

A

Antioxidant (Chelating agent)

24
Q

Types of Liquid Dosage Forms

A

Solution, Emulsion, Suspension

25
Q

Advantages of Solutions

A

Homogeneous - content uniformity
Easy to manufacture
Good bioavailability

26
Q

Two things to know in designing a buffer

A

Desired pH value and buffer capacity??

27
Q

What needs to be done to minimize irritation if solution pH cannot match bodily fluid pH?

A

Minimize buffering capacity
Minimize volume
Administer slowly

28
Q

Antimicrobial preservatives mechanism of action

A

Alcohols, Acids, Esters (parabens)–> Hydrophobic interactions with bacteria
Quaternary ammonium compounds–> Electrostatic forces interact with bacteria membrane

29
Q

Polysorbate 80 (tween 80)

A

Wetting agent (surfactant)

Dosage Forms II (1 decks)

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