Exam #1: Endocrine System & Blood Flashcards
What are the two classes of hormones?
Steroid, amino acid based
Which class of hormone (steroid or amino acid based) are ALL lipid-soluble, meaning they CAN cross the plasma membrane?
Steroid
Which class of hormone (steroid or amino acid based) is usually water-soluble, meaning it can NOT cross the plasma membrane?
Amino acid based
What tool does the Endocrine system use to have cell specificity?
Target cells
_____ ___: how specifity works for endocrine system hormones, including altering ___ ___ activity, increasing/decreasing the rates of normal cellular processes
Target cells
___ produce one or more of the following changes: stimulate mitosis, activate/deactivate enzymes, stimulate synthesis of enzymes & other proteins within the cell, alters plasma membrane permeability or membrane potential, or both, by opening/closing ion channels
Hormones
__-___ hormones (all amino-acid based hormones except thyroid) act on receptors in the plasma membrane (usually done via regulatory molecules called G proteins to 1 or more intracellular second messenger)
Water-soluble
___-___ hormones (steroid and thyroid hormones) act on receptors inside the cell, which directly activate genes
Lipid-soluble
____ stimuli activate secretion by direct response to changing blood levels of certain critical ions and nutrients (ex: parathyroid glands monitor the bodys crucial blood Ca2+ levels and release PTH as needed)
Humoral
___ stimuli activate secretion by nerve fibers stimulating hormone release (ex: when sympathetic nervous system stimulates the adrenal medulla to release norepinephrine/epinephrine in response to stress)
Neural
____ stimuli activate secretion by releasing and inhibiting hormones produced by the hypothalamus, regulate the secretion of most of anterior pituitary hormones & many anterior pituitary hormones in turn stimulate other endocrine organs to release their hormones
Hormonal
What is the concept that says a cell MUST have specific receptor proteins on its plasma membrane or in its interior to which a hormone can bind to? (Hint: three word answer)
Target cell activation
___-Regulation: when persistently low levels of a hormone can cause its target cells to form additional receptors for that hormone
Up
___-Regulation: prolonged exposure to high hormone concentrations that decrease the # of receptors for that hormone
Down
____: one hormone cannot exert its full effects without another hormone being present (Ex: lack of thyroid hormone delays reproductive development)
Permissiveness
___: when one or more hormone produces the same effects as the target cells and their combined effects are amplified (Ex: both glucagon and epinephrine cause the liver to release glucose to the blood, when working together, the amount of glucose released is about 150% of what would be released had they acted alone)
Synergism
___: occurs when one hormone imposes the action of another (Ex: this happens to insulin by glucagon; these types of relationships may compete for the same receptors, act through different metabolic pathways, or even cause down-regulation of the receptors for the opposing hormone)
Antagonism
What hormone is this description describing?
Function: metabolic hormone, protein synthesis & mitosis
Non-tropic, released by the Anterior Pituitary
GH
What hormone is this description describing?
Function: milk production for females
Non-tropic, released by the anterior pituitary
Prolactin
What hormone is this description describing?
Function: activate thyroid gland
Tropic, released by the anterior pituitary
TSH (thyroid stimulating hormone)
What hormone is this description describing?
Function: activate adrenal gland cortex
Tropic hormone, released by the anterior pituitary
ACTH (Adrenocorticotropin hormone)
What hormone is this description describing?
Function: activate sperm and egg production by the gonads
Tropic-hormone, released by the anterior pituitary gland
FSH (follicle stimulating hormone)
What hormone is this description describing?
Function: activate reproductive hormone production by the gonads
Tropic-hormone, released by the anterior pituitary
LH (luteinizing hormone)
What hormone is this description describing?
Function: aids in regulation of sleep cycles
Released by the pineal gland
Melatonin
What hormone is this description describing?
Function: decreases blood glucose
Produced by the beta cells in the pancreas, considered a hypoglycemic hormone
Insulin
What hormone is this description describing?
Function: increases blood glucose
Produced by alpha cells in the pancreas, considered a hyperglycemic hormone
Glucagon
Glycogenesis or Gluconeogenesis? : breakdown of glycogen to glucose
Glycogenesis
Glycogenesis or Gluconeogenesis? : synthesis of glucose from lactic acid & noncarbohydrates
Gluconeogenesis
What hormone is this description describing?
Function: in the uterus (stimulates contractions during childbirth), in the mammary glands (milk ejection), in the brain (“love” neurotransmitter, included with the mother/child bond)
Produced by Posterior Pituitary, uses positive feedback
Oxytocin
What hormone is this description describing?
Function: when targeting the kidney tubules (reabsorb more water, inhibiting/preventing urine formation), when targeting blood vessels at high concentrations (vasoconstriction)
Produced by Posterior Pituitary, net resulting in an increase in blood volume and pressure
ADH (antidiuretic hormone)
What 2 hormones is this description describing?
Function: metabolic rate, regulation of growth and development (skeletal, nervous, & reproductive systems), maintenance of blood pressure (increases ANS receptors in blood vessels)
Produced by the thyroid
T3 and T4 (TH)
What hormone is this description describing?
Function: (when at higher doses than normal) inhibits osteoclasts and released of Ca2+ from bone matrix, stimulates Ca2+ uptake and incorporation into bone matrix
Produced by thyroid, antagonist to PTH
Calcitonin
What hormone is this description describing?
Function: released in the event of hypocalcemia (low blood Ca2+) causing Ca2+ reabsorption in kidney tubules, activation of Vitamin D by kidney & osteoclast activity in bone causing Ca and PO release into blood
Produced by parathyroid
Parathyroid hormone (PH)
The primary hormone from the mineralocorticoids is ____.
Aldosterone
The primary hormone from the glucocorticoids is ____.
Cortisol
The primary hormone from the gonadocorticoids is ____.
Weak androgens
___ ___: onset of puberty, appearance of secondary sex characteristics, sex drive in women, estrogen in postmenopausal women (included in the gonadocorticoids class released within the adrenal cortex)
Weak androgens
___: Na+ absorption and water retention, elimination of K+, released in the mineralocorticoids class by the adrenal cortex)
Aldosterone
___: helps us resist stressors, influences metabolism of most cells, keep blood glucose levels relatively constant. maintains blood pressure by rising action of vasoconstrictors (included in the glucocorticoids class released by the adrenal cortex)
Cortisol
The adrenal medulla releases two hormones that cause the “___ or ___” response.
Fight or flight
Endocrine glands differ from exocrine glands in that they do NOT
a. have a blood supply
b. have ducts
c. secrete chemical messengers
d. have cells
B
Hormones that directly activate genes are classified as
a. amino acid based
b. water soluble
c. lipid soluble
d. G proteins
C
The target organ of the hormone erythropoietin is the ___
a. kidney (what makes it)
b. liver
c. thymus
d. red bone marrow
D
AB- can donate to who
a. O negative
b. B negative
c. AB positive
d. B neg and AB neg
C
The target organ of thyrotropin-releasing hormone is the ___
a. anterior pituitary
b. posterior pituitary
c. hypothalamus
d. thyroid
A
A positive receives all except
a. O+
b. O-
c. A+
d. A-
e. AB+
E
Which hormone directly causes the reproductive organs to release estrogen or testosterone?
a. GnRH
b. FSH
c. LH
d. CIH
C
Most of the amino acid-based hormones affect the target organs using __
a. intracellular second messengers
b. intracellular receptors
c. direct activation of genes
d. relay proteins
A
Which of the following are present in a mature red blood cell?
a. nucelus
b. plasma membrane
c. ribosome
d. mitochondrion
B
The anterior pituitary stimulates other endocrine organs by secreting a group of hormones called ___.
a. releasing hormones
b. target hormones
c. tropic hormones
d. stimulating hormones
C
O+ has which of the following antibodies
a. anti-Rh
b. anti-A
c. anti-B
d. anti-AB
e. anti-A and anti-B
E
This hormone is important in sodium regulation and therefore water balance
a. aldosterone
b. ADH
c. cortisol
d. ACTH
A
Where is oxytocin produced
a. anterior pituitary gland
b. posterior pituitary gland
c. hypothalamus
d. ovary
C
The protein backbone of a blood clot is ____.
a. thrombin (turns the fibrinogen into fibrin)
b. plasmin
c. heparin
d. fibrin
D
The universal recipient is ___.
a. Type O
b. Type AB
c. Type A
d. Type B
B
These cells contain histamine and are the least numerous of the white blood cellls
a. neutrophils
b. eosinophils
c. mast cells
d. basophils
D
What are the effects of insulin?
a. increased glucose uptake by the bodys cells
b. increased glycogenesis by the liver
c. increased glycolysis by the bodys cells
d. all of the other choices are correct.
D
The levels of a hormone increase in response to some stimulus, but then decrease once the issue has been resolved. This regulatory process is called ___.
a. negative feedback
b. positive feedback
c. reciprocal inhibition
d. down regulation
A
In which region of the adrenal gland is aldosterone produced?
a. zona reticularis
b. adrenal cortex
c. zona fasiculata
d. adrenal medulla
B
AB+ contains what antigens
a. A
b. B
c. Rh
d. A, B, and Rh
e. No antigens
D
The epiphyseal plate is the target organ of this hormone.
a. GH
b. ACTH
c. glucagon
d. PTH
A
Platelets are fragments of which cells?
a. leukocytes
b. thrombocytes
c. megakaryocytes
d. reticulocytes
C
Which area of the brain regulates the endocrine system?
a. cerebral cortex
b. hypothalamus
c. neurohypophysis
d. thalamus
B