Exam 1 - endocrine Flashcards
1
Q
Hormones used for diagnostic testing only?
A
TSH, TRH, ACTH, GHRH, CRH
2
Q
growth hormone analogue?
A
somatotropin
3
Q
MOA of somatotropin
A
- increase bone length, organs, and mm
- stimulates erythropoietin
- increases lipolysis
- reg. nutrients
4
Q
dosing of GH
A
3-7x per week SQ
5
Q
SE of somatotropin
A
kids - arthralgia, HA, edema, growing pains
Adults - arthralgia, stiffness, back pain, carpal tunnel, edema, HA, URIs
critically ill - increased mortality
6
Q
somatostatin analogue
A
octreotide (GH antagonist)
7
Q
MOA of octreotide
A
inhibit release of insulin, glucagon, GH, & gastrin
8
Q
Uses of octreotide
A
- gastrinoma
- insulinoma
- rare diarrhea
- esophageal varices bleed
- acromegally
- pituitary adrenoma
9
Q
SE of octreotide
A
- hypoglycemia
- hypothyroidism
- arrythmias
- biliary tract disorders
- GI (+ malabsorption)
10
Q
FSH analogue
A
hCG
11
Q
MOA of hCG
A
stimulates ovulation & spermatogenesis (IVF)
12
Q
GnRH analogs (4)
A
- leuprolide
- goserelin
- histrelin
- nafarelin
13
Q
MOA of GnRH analogs
A
decrease FHS = decrease testosterone & estrogen
14
Q
uses of GnRH analogs
A
- prostate/ovarian/breast cancer (goserelin & leuprolide)
- controlled ovarian hyperstimulation
- endometriosis & fibroids (nafarelin)
15
Q
ADRs of GnRH analogs
A
- HA
- light-headed
- nausea
- flushing
- menopause/androgen deprivation Sx