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Endo 2 > Exam 1 drugs > Flashcards

Exam 1 drugs Flashcards

1
Q

Somatropin

A

jak stat receptor to increase IGF-1
tx GH deficiency, dwarfism
CI = active malignancy

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2
Q

Mecasermin

A

TKR agonist (IGF-1 receptor)
tx growth failure in kids with IGF1 def that is not responsive to Somatropin

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3
Q

Octreotide / Lanreotide

A

somatostatin analogs - inhibits GH

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4
Q

Octreotide / Lanreotide

A

agonists at somatostatin Gi GPCRs
tx ant pit adenomas that secrete GH

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5
Q

Somatropin drug type

A

growth hormone analog

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6
Q

Mecasermin drug type

A

IGF-1 agonist

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7
Q

GH antagonist

A

Pegvisomant

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8
Q

Pegvisomant

A

GH jak stat receptor antagonist
inhibits IGF1 production by liver

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9
Q

dopamine agonists

A

Bromocriptine / Cabergoline

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10
Q

Bromocriptine / Cabergoline

A

act on GPCR to normalize PRL levels & stop breast milk production
AEs: CNS & psych (confusion, delusions, hallucination)

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11
Q

vasopressin receptor agonists

A

Vasopressin & Desmopressin

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12
Q

Vasopressin

A

agonist at V1 & V2 GPCRs
- V1 = vasoconstrict via Gq
- V2 = inc H2O reabsorp via Gs

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13
Q

Desmopressin (DDVAP)

A

selective for V2, minimizing vasoconstriction effects via GPCR

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14
Q

vasopressin receptor antagonists

A

Conivaptan, Tolvaptan

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15
Q

Conivaptan / Tolvaptan

A

V2 antags = promote excretion of free H2O
Tolvaptan = higher potency, risk of hepatotox

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16
Q

Levothyroxine (T4)

A

converted to T3 & binds nuclear receptors to modulate transcription & protein synthesis
- absorption delayed by food & antacid consumption, bran, fiber, cholestyramine

17
Q

Liothyronine (T3)

A

binds nuclear receptors
same as T4

18
Q

Liotrix

A

synthetic T4:T3 with ration 4:1

19
Q

Desiccated thyroid

A

from animal thyroids, contains foreign protein source

20
Q

what 3 things/drugs inhibit TPO enzyme to prevent iodination of tyrosine residues?

A

Methimazole, PTU, high iodide levels

21
Q

what 3 drugs block conversion of T4 into T3?

A

Propranolol, Amiodarone, Corticosteroids

22
Q

who is more potent, T3 or T4?

A

T3

23
Q

Methimazole / PTU

A

inhibit thyroid peroxidase catalyzed rxns
inhibit iodination = dec I-Tg
inhibit coupling = dec T3 & T4
don’t use methimazole in pregnancy

24
Q

KI-

A

antithyroid when administered in excess
inhibit hormone release

25
Q

Radioactive iodine (131I) sodium

A

preferred in toxic multinodular goiter
CI in pregnancy & breast feeding

26
Q

beta blockers

A

rapidly mitigates tachyarrhythmias from excessive T3 in thyroid storm or OD (inhibit cardiac beta 1)

27
Q

what does Hydrocortisone treat?

A

Addison disease & acute adrenal insufficiency

28
Q

prednisone

A

strong anti inflammatory
converted to prednisolone in liver

29
Q

Prednisolone

A

active metabolite of Prednisone
effective for ophthalmic use

30
Q

betamethasone

A

long acting, very potent, crosses placental barrier easier
- used to stimulate fetal lung maturation in prevention of infant resp distress syndrome

31
Q

Dexamethasone

A

used in suppression test to distinguish source of Cushing syndrome

32
Q

Fludrocortisone

A

synthetic mineralocorticoid
causes salt & water retention
Combined with hydrocortisone to to Addison’s
SE: edema

33
Q

Ketoconazole

A

anti mycotic, anti fungal

34
Q

Metyrapone

A

diagnostic in adrenal function tests
causes acne & hirsutism in females
action: causes inc in ACTH in pt with normal pit

35
Q

Mifepristone

A

glucocorticoid receptor antag
tx Cushing’s d/t ectopic ACTH production & adrenal CA
emergency contraceptive

36
Q

Spironolactone

A

androgen antag & aldosterone antag
tx: primary aldosteronism, hirsutism
SE: hyperK+, gynecomastia

Endo 2 (1 decks)

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