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864 - Therapeutics IV > Exam 1 drugs > Flashcards

Exam 1 drugs Flashcards

1
Q

5 Fluorouracil: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target - antimetabolite, pyrimidine analog (uracil analog), interferes with pyrimidine nucleotide synthesis, also interfere with DNA/RNA function/replication

Phase of cell cycle - S

Dose limiting side effects -

Important drug interactions - Thymidine (negates effects), Leucovorate (increases effects)

Unique resistance mechanisms - downregulation of activating enzymes that convert 5-FU -> fd-UMP, upregulation of thymidylate synthase

Genetic or epigenetic testing - PDP enzyme breaks down 5-FU, ~5% of population may be deficient (increases toxicity)

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2
Q

Cytarabine (Ara-C): Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target - antimetabolite, pyrimidine analog (cytosine), inhibits DNA polymerase, also interfere with DNA/RNA function/replication

Phase of cell cycle - S

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms - Downregulation of activating enzymes, upregulation of cytidine deaminase, downregulation of transporter to move drug into cells

Genetic or epigenetic testing -

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3
Q

6-Mercaptopurine (6-MP): Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target - antimetabolite, purine analog, inhibits multiple enzymes to block synthesis of purine nucleotides

Phase of cell cycle - S

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms - TMPT inactivates 6-MP, ~10% children LOF (increases toxicity)

Genetic or epigenetic testing -

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4
Q

Methotrexate: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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5
Q

Chlorambucil: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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6
Q

Cyclophosphamide: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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7
Q

Mitomycin C: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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8
Q

Cisplatin: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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9
Q

Irinotecan: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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10
Q

Doxorubicin: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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11
Q

Etoposide: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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12
Q

Bleomycin: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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13
Q

Vincristine: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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14
Q

Paclitaxel: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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15
Q

Erubulin: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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16
Q

Abiraterone: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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17
Q

Tamoxifen: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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18
Q

Fulvestrant: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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19
Q

Prednisolone: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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20
Q

Letrozole: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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21
Q

Exemestane: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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22
Q

Leuprolide: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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23
Q

Imatinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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24
Q

Ponatinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

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25
Q

Midostaurin: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

26
Q

Quizartinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

27
Q

Crenolanib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

28
Q

Sirolimus: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

29
Q

Alectinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

30
Q

Dabrafenib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

31
Q

Trametinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

32
Q

Vemurafenib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

33
Q

Acalabrutinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

34
Q

Gefitinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

35
Q

Lapatinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

36
Q

Afatinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

37
Q

Tucatinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

38
Q

Osimertinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

39
Q

Pembrolizumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

40
Q

Atezolizumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

41
Q

Ipilimumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

42
Q

Trastuzumab, Pertuzimab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

43
Q

Cetuximab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

44
Q

Bevacizumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

45
Q

Ramucirumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

46
Q

Rituximab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

47
Q

Daratumumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

48
Q

Trastuzumab emtansine: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

49
Q

Trastuzumab deruxtecan: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

50
Q

Blinatumomab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

51
Q

Mosunetuzumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

52
Q

Teclistamab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

53
Q

Taquetamab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

54
Q

Sipuleucel-T: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

55
Q

CAR-T: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

56
Q

Olabarip: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

57
Q

Palbociclib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target - CDK4/5 kinase inhibitor

Phase of cell cycle - checkpoint inhibitor in G1 phase

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

58
Q

Bortemzomib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

59
Q

5-azacytosine: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

60
Q

Venetoclax: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

61
Q

Pomalidomide: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

A

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

864 - Therapeutics IV (6 decks)

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