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PK PD1 > Exam 1 Concepts > Flashcards

Exam 1 Concepts Flashcards

1
Q

(IV Bolus) Increase in dose changes…

A

Czero inc, slope and half-life unchanged

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2
Q

(IV Bolus) Decrease in dose changes…

A

Czero dec, slope and half-life unchanged

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3
Q

(IV Bolus) Increase in CL changes…

A

slope inc, half-life dec, Czero unchanged

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4
Q

(IV Bolus) Decrease in CL changes…

A

slope dec, half-life inc, Czero unchanged

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5
Q

(IV Bolus) Increase in V changes…

A

Czero and slope dec, half-life inc

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6
Q

(IV Bolus) Decrease in V changes…

A

Czero and slope inc, half-life dec

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7
Q

(IV Continuous Infusion) Increase in infusion rate changes…

A

Css inc, half-life and time to Css unchanged

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8
Q

(IV Continuous Infusion) Decrease in infusion rate changes….

A

Css dec, half-life and time to Css unchanged

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9
Q

(IV Continuous Infusion) Increase in CL changes…

A

Css, half-life and time to Css ALL dec

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10
Q

(IV Continuous Infusion) Decrease in CL changes…

A

Css, half-life and time to Css ALL inc

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11
Q

(IV Continuous Infusion) Increase in V changes…

A

half-life and time to Css inc, Css unchanged

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12
Q

(IV Continuous Infusion) Decrease in V changes…

A

half-life and time to Css dec, Css unchanged

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13
Q

(Multiple IV) Increase in CL changes…

A

everything (Cpav,ss half-life, time to ss, accum) dec BUT fluctuation inc *Cp01 unchanged

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14
Q

(Multiple IV) Decrease in CL changes…

A

everything (Cp01 half-life, time to ss, accum) inc BUT fluctuation dec *Cpva,ss unchanged

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15
Q

(Multiple IV) Increase in V changes…

A

Cp01 and fluctuation dec and half-life, time to ss, and accum inc

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16
Q

(Multiple IV) Decrease in V changes…

A

Cp01 and fluctuation inc and half-life, time to ss, and accum dec

PK PD1 (1 decks)

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