Exam #1: Cellular Basis for Behavior Flashcards

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1
Q
  • have a catechol nucleus that comes from the precursor structure tyrosine
  • has two carbons and an amine group
  • Tyrosine converts to DOPA by the addition of a hydroxyl group which is the direct precursor to Dopamine (a decarboxylase takes off the carboxyl groups, the COOH),
  • add an OH and take away a COOH to get dopamine, process ends here in dopamine neurons
  • hydroxylase adds an OH group, after dopamine when a hydroxylase adds an OH to the beta carbon, you get norepinephrine
A

catecholamine

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2
Q
  • produces mRNA (messenger RiboNucleic Acid)
  • Single stranded copy of the the DNA molecule
  • 4 bases (cytosine, guanine, adenine, and uracil [replaces thymine]) in a sequence that codes for the specific amino acid sequence of a protein
  • Exits the nucleus and travels to the cytoplasm
A

DNA transcription

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3
Q
  • reduction in the sensitivity of the postsynaptic cell
  • cell increases neurotransmitter influence- overwhelms post synaptic cell, which prompts the post synaptic cell to decrease receptor complement and become less sensitive to neurotransmitter presence (ex. drug addiction)
A

desensitization

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4
Q
  • SSRIs are inhibitors, they stop serotonin from being taken up by the receptors so there is more floating around
  • People respond well to SSRIs for the most part, they work really well, better for anxiety than depression.
  • Four people with depression can present with the same symptoms but have different comorbidities/different underlying pathology, and drugs don’t work the same in those populations.
  • We don’t have the diagnostic tools yet to test which one works best so we do symptom description diagnosis.
A

do SSRIs create more protein reuptake pumps or do they create more serotonin for the reuptake pumps to hold on to?

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5
Q

a molecule that binds to a receptor at a different location than agonists/antagonists and increases the ability of the receptor to bind to a ligand (i.e. neurotransmitter)

A

allosteric modifier

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6
Q

a piece of the membrane pinches back to form a new vesicle

A

endocytosis

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7
Q

a short chain of amino acids released from the brain into the blood stream to act as neurochemical signals between brain and body

A

peptide hormones

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8
Q

a short chain of amino acids released in the brain and used as a neurochemical signal between neurons; they are “metabolically expensive” (ie, they take a lot of energy to make), so they tend to act at low concentrations for a long period of time as neuromodulators (i.e. endorphins, vasopressin, oxytocin, etc)

A

peptide neurotransmitters

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9
Q

acetylcholine

A

small molecule neurotransmitter known for thought, learning and memory; activates muscle action in the body, and attention and awakening.

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10
Q

acetylcholine synthesis

A

synthesized in the pre-synaptic terminal by the enzyme cholineacetyltransferase (ChAT) which fuses to acetate (Acetyl-CoA) and choline together → ACh

Once released, ACh binds to receptors on the post synaptic cell, and then either diffuses out of the synapse or is metabolized by enzymes like acetylcholinesterase

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11
Q

affinity

A

how fast and strong a ligand binds to a receptor

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12
Q

agonist

A

molecules that bind to a receptor and activate it biologically

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13
Q

allosteric modifier

A

a molecule that binds to a receptor at a different location than agonists/antagonists and increases the ability of the receptor to bind to a ligand (i.e. neurotransmitter)

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14
Q

AMPA

A

most active GLU receptor; causes neuron excitation due to increase Na+ influx

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15
Q

an up-regulation problem characterized increase in sensitivity of the postsynaptic cell caused when:

  1. Presynaptic cell decreases neurotransmitter influence – starves postsynaptic cell
  2. Postsynaptic cell increases receptor complement and becomes supersensitive to any of the remaining neurotransmitter around the cell (ex. phantom limb pain)
A

denervation supersensitivity

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16
Q

antagonist

A

molecules that bind to a receptor but do not activate it biologically; usually have a high affinity so the receptor is literally blocked from functioning

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17
Q

anterograde

A

movement of ions towards the terminal

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18
Q

attracted to water

A

hydrophilicity

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19
Q

axon

A

long slender projection off the soma that sends signals to other neurons; surrounded by a myelin sheath to protect and insulate it

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20
Q

axoplasmic transport

A

transport of new proteins to distant locations in the neurites

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21
Q

biogenic amines

A

family of neurotransmitters that include catecholamines (dopamine (DA), norepinephrine (NE)), and the indolamine, serotonin (5HT)

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22
Q

bipolar

A

two neurites originating from the soma (i.e. interneurons)

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23
Q

bulbous ending at the end of the axon, contains synaptic vesicles which are filled with neurotransmitters

A

pre-synaptic terminal

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24
Q

calcium helps the SNP proteins to come together and twist and bind synaptobrevin during exocytosis and then twist and release

A

calcium-mediated release

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25
Q

calcium-mediated release

A

calcium helps the SNP proteins to come together and twist and bind synaptobrevin during exocytosis and then twist and release

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26
Q

catecholamine

A
  • have a catechol nucleus that comes from the precursor structure tyrosine
  • has two carbons and an amine group
  • Tyrosine converts to DOPA by the addition of a hydroxyl group which is the direct precursor to Dopamine (a decarboxylase takes off the carboxyl groups, the COOH),
  • add an OH and take away a COOH to get dopamine, process ends here in dopamine neurons
  • hydroxylase adds an OH group, after dopamine when a hydroxylase adds an OH to the beta carbon, you get norepinephrine
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27
Q

causes neuron excitation due to increase Na+ influx

A

kainate

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28
Q

causes neuron excitation due to increase Na+/Ca2+ influx

A

NMDA

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29
Q

Cells always contact from the presynaptic terminal to the dendrites with information flwoing from the dendrite to the soma to the axon to the terminal (axo-dendritic synapses)

A

Original Law of Dynamic Polarization

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30
Q

Cells contact each other in more ways than just presynaptic to postsynaptic:

Axo-somatic synapses– Info flows pre-synaptic terminal à soma* via Axo-axonic synapses – Info flows pre-synaptic terminal à axon* via Axo-synaptic synapses – Info flows pre-synaptic terminal à pre-synaptic terminal

A

Revised Law of Dynamic Polarization

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31
Q

cells that myelinate axons in the brain and spinal cord as part of the CNS

A

oligodendrocytes

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32
Q

cells that myelinate axons in the PNS

A

schwann cells

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33
Q

chemical signals (trophic factors) are proteins that help nerve cells develop and recognize each other are exchanged between potential synaptic partners

A

chemoaffinity hypothesis

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34
Q

chemoaffinity hypothesis

A

chemical signals (trophic factors) are proteins that help nerve cells develop and recognize each other are exchanged between potential synaptic partners

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35
Q

cholinergic synapse

A

the connection between a motor neuron and a skeletal muscle

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36
Q

coating on axons that insulates the electrochemical signals

A

myelin

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37
Q

contiuum of efficacy

A

when a neurotransmitter binds and opens up a channel, it doesn’t just stay and keep it open, it jumps off and then could bind again somewhere else

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38
Q

dendrites

A

tree-like extensions off the soma that receive signals from other neurons

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39
Q

denervation supersensitivity

A

an up-regulation problem characterized increase in sensitivity of the postsynaptic cell caused when:

  1. Presynaptic cell decreases neurotransmitter influence – starves postsynaptic cell
  2. Postsynaptic cell increases receptor complement and becomes supersensitive to any of the remaining neurotransmitter around the cell (ex. phantom limb pain)
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40
Q

desensitization

A
  • reduction in the sensitivity of the postsynaptic cell
  • cell increases neurotransmitter influence- overwhelms post synaptic cell, which prompts the post synaptic cell to decrease receptor complement and become less sensitive to neurotransmitter presence (ex. drug addiction)
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41
Q

determine nerve cell shape and movement (i.e. actin, tubulin, elastin)

A

structural proteins

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42
Q

basics of cell biology

A

your DNA (genes) is transcribed into RNA (genetic message) which is translated into proteins (functional molecules)

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43
Q

DNA transcription

A
  • produces mRNA (messenger RiboNucleic Acid)
  • Single stranded copy of the the DNA molecule
  • 4 bases (cytosine, guanine, adenine, and uracil [replaces thymine]) in a sequence that codes for the specific amino acid sequence of a protein
  • Exits the nucleus and travels to the cytoplasm
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44
Q

do SSRIs create more protein reuptake pumps or do they create more serotonin for the reuptake pumps to hold on to?

A
  • SSRIs are inhibitors, they stop serotonin from being taken up by the receptors so there is more floating around
  • People respond well to SSRIs for the most part, they work really well, better for anxiety than depression.
  • Four people with depression can present with the same symptoms but have different comorbidities/different underlying pathology, and drugs don’t work the same in those populations.
  • We don’t have the diagnostic tools yet to test which one works best so we do symptom description diagnosis.
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45
Q

dopamine

A

small molecule neurotransmitter known for pleasure;
also addiction, movement and motivation. People repeat behaviors that lead to this chemical release.

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46
Q

each schwann cells dedicates itself to a small segment of an axon

A

schwann cell myelination

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47
Q

endocytosis

A

a piece of the membrane pinches back to form a new vesicle

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48
Q

endorphins

A

peptide neurotransmitters known for euphoria; released during exercise, excitement, and sex; reduces pain

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49
Q

enzyme

A

Substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction

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50
Q

epilepsy

A

loss of GABA producing neurons, treated with GABA stimulating drugs

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51
Q

exocytosis

A

fusion of the synaptic vesicle with the plasma membrane

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52
Q

family of neurotransmitters that include catecholamines (dopamine (DA), norepinephrine (NE)), and the indolamine, serotonin (5HT)

A

biogenic amines

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53
Q

filopedia

A

“finger feet” that come out of the growth cone

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54
Q

“finger feet” that come out of the growth cone

A

filopedia

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55
Q

fluid mosaic model

A

in a cell, the hydrophobic interior of the lipid bilayer acts as a very effective barrier to e-charged particles like water (H2O) and salt (Na+, K+) trying to get in and out of the cell.

different proteins in the membrane act as hydrophilic channels and pumps (functional components)

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56
Q

function of neurotransmitters

A

it is the property of a receptor, not the property of the molecule itself

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57
Q

fusion of the synaptic vesicle with the plasma membrane

A

exocytosis

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58
Q

GABA

A

small molecule neurotransmitter known for inhibition; calms firing nerves in the central nervous system; high levels improve focus, low levels cause anxiety; also contributes to motor control and vision.

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59
Q

GABA A receptors

A

ionotropic receptors that function as Cl- channels that produce neuronal inhibition; they have at least two allosteric binding sites that when bound increase the ability of the receptor to bind to the neurotransmitter; there is one site of action for benzodiazepines (sedatives) another for barbiturates (tranquilizers)

60
Q

glutamate

A

small molecule neurotransmitter known for memory; most common neurotransmitter; involved in learning and memory, and the regulation of development and creation of nerve contacts.

61
Q

glycine

A

important amino acid for inhibition, especially in the spinal cord, where it is used instead of GABA

62
Q

glycine antagonist used as a poison; causes spinal seizure

A

strychnine

63
Q

growth cone

A

tip of a growing neuronal axon

64
Q

how biologically effective a ligand is once bound

A

potency

65
Q

how fast and strong a ligand binds to a receptor

A

affinity

66
Q

hydrophilicity

A

attracted to water

67
Q

hydrophobicity

A

repelled from water

68
Q

If correct synaptic partner:
- filopodia flatten out
- presynaptic and postsynaptic densities appear
- clusters of proteins like neurotransmitter receptors and reuptake pumps

A

withdrawal and approach cycles

69
Q

important amino acid for inhibition, especially in the spinal cord, where it is used instead of GABA

A

glycine

70
Q

in a cell, the hydrophobic interior of the lipid bilayer acts as a very effective barrier to e-charged particles like water (H2O) and salt (Na+, K+) trying to get in and out of the cell.

different proteins in the membrane act as hydrophilic channels and pumps (functional components)

A

fluid mosaic model

71
Q

In the 1890’s, it was theorized that the brain was composed of individual, highly specialized cells called neurons

A

Neuron Doctrine

72
Q

in this case, when a neurotransmitter binds to a receptor, the binding activates a signal for the channel to open. It isn’t a channel itself, but binding to the receptor still opens a channel

A

metabotropic receptor

73
Q

indolamine

A

starts from the amino acid tryptophan that looks like an indol group,
- hydroxylase adds an OH group, and then the decarboxylase removes a COOH

74
Q

insecticides

A

manmade AChE blockers

75
Q

ionotropic receptor

A

neurotransmitter receptors that bind to a neurotransmitter, and the receptor itself becomes a channel where the ions move across

76
Q

ionotropic receptors that function as Cl- channels that produce neuronal inhibition; they have at least two allosteric binding sites that when bound increase the ability of the receptor to bind to the neurotransmitter; there is one site of action for benzodiazepines (sedatives) another for barbiturates (tranquilizers)

A

GABA A receptors

77
Q

it is the property of a receptor, not the property of the molecule itself

A

function of neurotransmitters

78
Q

kainate

A

causes neuron excitation due to increase Na+ influx

79
Q

long slender projection off the soma that sends signals to other neurons; surrounded by a myelin sheath to protect and insulate it

A

axon

80
Q

loss of GABA producing neurons, treated with GABA stimulating drugs

A

epilepsy

81
Q

manmade AChE blockers

A

insecticides

82
Q

many neurites originating from the soma (i.e. motor neurons or pyramidal neurons)

A

multipolar

83
Q

metabotropic receptor

A

in this case, when a neurotransmitter binds to a receptor, the binding activates a signal for the channel to open. It isn’t a channel itself, but binding to the receptor still opens a channel

84
Q

molecules that bind to a receptor and activate it biologically

A

agonist

85
Q

molecules that bind to a receptor but do not activate it biologically; usually have a high affinity so the receptor is literally blocked from functioning

A

antagonist

86
Q

most active GLU receptor; causes neuron excitation due to increase Na+ influx

A

AMPA

87
Q

movement of ions towards the soma

A

retrograde

88
Q

movement of ions towards the terminal

A

anterograde

89
Q

multipolar

A

many neurites originating from the soma (i.e. motor neurons or pyramidal neurons)

90
Q

myelin

A

coating on axons that insulates the electrochemical signals

91
Q

naturally occurring drug that blocks AChE

A

physostigmine

92
Q

neurochemistry

A

the brain moves ions, making the cell either become positive and excited (on), or negative and inactive (off)

93
Q

neuromodulator

A

small peptide that acts to bind to an allosteric site on a receptor to enhance the binding of that receptor to a natural neurotransmitter

94
Q

Neuron Doctrine

A

In the 1890’s, it was theorized that the brain was composed of individual, highly specialized cells called neurons

95
Q

neurotransmitter receptors

A

specialized proteins embedded in the membrane of the post-synaptic neuron that bind neurotransmitters released into the synapse, opening a pore for charged ions (i.e. Na+, K+) and allowing them to enter/exit the neuron

96
Q

neurotransmitter receptors that bind to a neurotransmitter, and the receptor itself becomes a channel where the ions move across

A

ionotropic receptor

97
Q

NMDA

A

causes neuron excitation due to increase Na+/Ca2+ influx

98
Q

noradrenaline

A

small molecule neurotransmitter known for concentration; affects attention and responding actions in the brain, contracts blood vessels, increases blood flow.

99
Q

oligodendrocyte myelination

A

oligodendrocytes myelinate multiple axons

100
Q

oligodendrocytes

A

cells that myelinate axons in the brain and spinal cord as part of the CNS

101
Q

oligodendrocytes myelinate multiple axons

A

oligodendrocyte myelination

102
Q

one neurite originating from the soma (i.e. sensory neurons)

A

unipolar

103
Q

Original Law of Dynamic Polarization

A

Cells always contact from the presynaptic terminal to the dendrites with information flwoing from the dendrite to the soma to the axon to the terminal (axo-dendritic synapses)

104
Q

orthograde axoplasmic transport

A

the way in which peptide transmitters are packaged into vesicles in the cell body and sent down the axon to the synaptic terminal

  • they are first broken down into small “active” peptides
  • after release they diffuse away from synapse and are broken down by enzymes (proteolysis)
105
Q

parikaryon

A

soma or cell body, contains the nucleus

106
Q

peptide hormones

A

a short chain of amino acids released from the brain into the blood stream to act as neurochemical signals between brain and body

107
Q

peptide neurotransmitters

A

a short chain of amino acids released in the brain and used as a neurochemical signal between neurons; they are “metabolically expensive” (ie, they take a lot of energy to make), so they tend to act at low concentrations for a long period of time as neuromodulators (i.e. endorphins, vasopressin, oxytocin, etc)

108
Q

peptide neurotransmitters known for euphoria; released during exercise, excitement, and sex; reduces pain

A

endorphins

109
Q

physostigmine

A

naturally occurring drug that blocks AChE

110
Q

potency

A

how biologically effective a ligand is once bound

111
Q

pre-synaptic terminal

A

bulbous ending at the end of the axon, contains synaptic vesicles which are filled with neurotransmitters

112
Q

presynaptic inhibition

A

when GABA blocks the ability of a synaptic terminal to release neurotransmitter

113
Q

repelled from water

A

hydrophobicity

114
Q

retrograde

A

movement of ions towards the soma

115
Q

Revised Law of Dynamic Polarization

A

Cells contact each other in more ways than just presynaptic to postsynaptic:

Axo-somatic synapses– Info flows pre-synaptic terminal à soma* via Axo-axonic synapses – Info flows pre-synaptic terminal à axon* via Axo-synaptic synapses – Info flows pre-synaptic terminal à pre-synaptic terminal

116
Q

schwann cell myelination

A

each schwann cells dedicates itself to a small segment of an axon

117
Q

schwann cells

A

cells that myelinate axons in the PNS

118
Q

serotonin

A

small molecule neurotransmitter known for mood;
contributes to well-being and happiness, helps sleep cycle and digestive system regulation; affected by
exercise and light exposure.

119
Q

small molecule neurotransmitter known for concentration; affects attention and responding actions in the brain, contracts blood vessels, increases blood flow.

A

noradrenaline

120
Q

small molecule neurotransmitter known for inhibition; calms firing nerves in the central nervous system; high levels improve focus, low levels cause anxiety; also contributes to motor control and vision.

A

GABA

121
Q

small molecule neurotransmitter known for memory; most common neurotransmitter; involved in learning and memory, and the regulation of development and creation of nerve contacts.

A

glutamate

122
Q

small molecule neurotransmitter known for mood;
contributes to well-being and happiness, helps sleep
cycle and digestive system regulation; affected by
exercise and light exposure.

A

serotonin

123
Q

small molecule neurotransmitter known for pleasure;
also addiction, movement and motivation. People repeat behaviors that lead to this chemical release.

A

dopamine

124
Q

small molecule neurotransmitter known for thought, learning and memory; activates muscle action in the body, and attention and awakening.

A

acetylcholine

125
Q

small peptide that acts to bind to an allosteric site on a receptor to enhance the binding of that receptor to a natural neurotransmitter

A

neuromodulator

126
Q

soma or cell body, contains the nucleus

A

parikaryon

127
Q

specialized proteins embedded in the membrane of the post-synaptic neuron that bind neurotransmitters released into the synapse, opening a pore for charged ions (i.e. Na+, K+) and allowing them to enter/exit the neuron

A

neurotransmitter receptors

128
Q

SSRI neuroplasticity

A

when someone takes SSRIs it doesn’t cause receptor down-regulation because it is a slow, system level process

129
Q

starts from the amino acid tryptophan that looks like an indol group,
- hydroxylase adds an OH group, and then the decarboxylase removes a COOH

A

indolamine

130
Q

structural proteins

A

determine nerve cell shape and movement (i.e. actin, tubulin, elastin)

131
Q

strychnine

A

glycine antagonist used as a poison; causes spinal seizure

132
Q

Substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction

A

enzyme

133
Q

synthesized in the pre-synaptic terminal by the enzyme cholineacetyltransferase (ChAT) which fuses to acetate (Acetyl-CoA) and choline together → ACh

Once released, ACh binds to receptors on the post synaptic cell, and then either diffuses out of the synapse or is metabolized by enzymes like acetylcholinesterase

A

acetylcholine synthesis

134
Q

the brain moves ions, making the cell either become positive and excited (on), or negative and inactive (off)

A

neurochemistry

135
Q

the connection between a motor neuron and a skeletal muscle

A

cholinergic synapse

136
Q

the way in which peptide transmitters are packaged into vesicles in the cell body and sent down the axon to the synaptic terminal

  • they are first broken down into small “active” peptides
  • after release they diffuse away from synapse and are broken down by enzymes (proteolysis)
A

orthograde axoplasmic transport

137
Q

tip of a growing neuronal axon

A

growth cone

138
Q

transport of new proteins to distant locations in the neurites

A

axoplasmic transport

139
Q

tree-like extensions off the soma that receive signals from other neurons

A

dendrites

140
Q

two neurites originating from the soma (i.e. interneurons)

A

bipolar

141
Q

unipolar

A

one neurite originating from the soma (i.e. sensory neurons)

142
Q

when a neurotransmitter binds and opens up a channel, it doesn’t just stay and keep it open, it jumps off and then could bind again somewhere else

A

contiuum of efficacy

143
Q

when GABA blocks the ability of a synaptic terminal to release neurotransmitter

A

presynaptic inhibition

144
Q

when someone takes SSRIs it doesn’t cause receptor down-regulation because it is a slow, system level process

A

SSRI neuroplasticity

145
Q

withdrawal and approach cycles

A

If correct synaptic partner:
- filopodia flatten out
- presynaptic and postsynaptic densities appear
- clusters of proteins like neurotransmitter receptors and reuptake pumps

146
Q

your DNA (genes) is transcribed into RNA (genetic message) which is translated into proteins (functional molecules)

A

basics of cell biology