Exam #1: Cellular Basis for Behavior Flashcards
- have a catechol nucleus that comes from the precursor structure tyrosine
- has two carbons and an amine group
- Tyrosine converts to DOPA by the addition of a hydroxyl group which is the direct precursor to Dopamine (a decarboxylase takes off the carboxyl groups, the COOH),
- add an OH and take away a COOH to get dopamine, process ends here in dopamine neurons
- hydroxylase adds an OH group, after dopamine when a hydroxylase adds an OH to the beta carbon, you get norepinephrine
catecholamine
- produces mRNA (messenger RiboNucleic Acid)
- Single stranded copy of the the DNA molecule
- 4 bases (cytosine, guanine, adenine, and uracil [replaces thymine]) in a sequence that codes for the specific amino acid sequence of a protein
- Exits the nucleus and travels to the cytoplasm
DNA transcription
- reduction in the sensitivity of the postsynaptic cell
- cell increases neurotransmitter influence- overwhelms post synaptic cell, which prompts the post synaptic cell to decrease receptor complement and become less sensitive to neurotransmitter presence (ex. drug addiction)
desensitization
- SSRIs are inhibitors, they stop serotonin from being taken up by the receptors so there is more floating around
- People respond well to SSRIs for the most part, they work really well, better for anxiety than depression.
- Four people with depression can present with the same symptoms but have different comorbidities/different underlying pathology, and drugs don’t work the same in those populations.
- We don’t have the diagnostic tools yet to test which one works best so we do symptom description diagnosis.
do SSRIs create more protein reuptake pumps or do they create more serotonin for the reuptake pumps to hold on to?
a molecule that binds to a receptor at a different location than agonists/antagonists and increases the ability of the receptor to bind to a ligand (i.e. neurotransmitter)
allosteric modifier
a piece of the membrane pinches back to form a new vesicle
endocytosis
a short chain of amino acids released from the brain into the blood stream to act as neurochemical signals between brain and body
peptide hormones
a short chain of amino acids released in the brain and used as a neurochemical signal between neurons; they are “metabolically expensive” (ie, they take a lot of energy to make), so they tend to act at low concentrations for a long period of time as neuromodulators (i.e. endorphins, vasopressin, oxytocin, etc)
peptide neurotransmitters
acetylcholine
small molecule neurotransmitter known for thought, learning and memory; activates muscle action in the body, and attention and awakening.
acetylcholine synthesis
synthesized in the pre-synaptic terminal by the enzyme cholineacetyltransferase (ChAT) which fuses to acetate (Acetyl-CoA) and choline together → ACh
Once released, ACh binds to receptors on the post synaptic cell, and then either diffuses out of the synapse or is metabolized by enzymes like acetylcholinesterase
affinity
how fast and strong a ligand binds to a receptor
agonist
molecules that bind to a receptor and activate it biologically
allosteric modifier
a molecule that binds to a receptor at a different location than agonists/antagonists and increases the ability of the receptor to bind to a ligand (i.e. neurotransmitter)
AMPA
most active GLU receptor; causes neuron excitation due to increase Na+ influx
an up-regulation problem characterized increase in sensitivity of the postsynaptic cell caused when:
- Presynaptic cell decreases neurotransmitter influence – starves postsynaptic cell
- Postsynaptic cell increases receptor complement and becomes supersensitive to any of the remaining neurotransmitter around the cell (ex. phantom limb pain)
denervation supersensitivity
antagonist
molecules that bind to a receptor but do not activate it biologically; usually have a high affinity so the receptor is literally blocked from functioning
anterograde
movement of ions towards the terminal
attracted to water
hydrophilicity
axon
long slender projection off the soma that sends signals to other neurons; surrounded by a myelin sheath to protect and insulate it
axoplasmic transport
transport of new proteins to distant locations in the neurites
biogenic amines
family of neurotransmitters that include catecholamines (dopamine (DA), norepinephrine (NE)), and the indolamine, serotonin (5HT)
bipolar
two neurites originating from the soma (i.e. interneurons)
bulbous ending at the end of the axon, contains synaptic vesicles which are filled with neurotransmitters
pre-synaptic terminal
calcium helps the SNP proteins to come together and twist and bind synaptobrevin during exocytosis and then twist and release
calcium-mediated release
calcium-mediated release
calcium helps the SNP proteins to come together and twist and bind synaptobrevin during exocytosis and then twist and release
catecholamine
- have a catechol nucleus that comes from the precursor structure tyrosine
- has two carbons and an amine group
- Tyrosine converts to DOPA by the addition of a hydroxyl group which is the direct precursor to Dopamine (a decarboxylase takes off the carboxyl groups, the COOH),
- add an OH and take away a COOH to get dopamine, process ends here in dopamine neurons
- hydroxylase adds an OH group, after dopamine when a hydroxylase adds an OH to the beta carbon, you get norepinephrine
causes neuron excitation due to increase Na+ influx
kainate
causes neuron excitation due to increase Na+/Ca2+ influx
NMDA
Cells always contact from the presynaptic terminal to the dendrites with information flwoing from the dendrite to the soma to the axon to the terminal (axo-dendritic synapses)
Original Law of Dynamic Polarization
Cells contact each other in more ways than just presynaptic to postsynaptic:
Axo-somatic synapses– Info flows pre-synaptic terminal à soma* via Axo-axonic synapses – Info flows pre-synaptic terminal à axon* via Axo-synaptic synapses – Info flows pre-synaptic terminal à pre-synaptic terminal
Revised Law of Dynamic Polarization
cells that myelinate axons in the brain and spinal cord as part of the CNS
oligodendrocytes
cells that myelinate axons in the PNS
schwann cells
chemical signals (trophic factors) are proteins that help nerve cells develop and recognize each other are exchanged between potential synaptic partners
chemoaffinity hypothesis
chemoaffinity hypothesis
chemical signals (trophic factors) are proteins that help nerve cells develop and recognize each other are exchanged between potential synaptic partners
cholinergic synapse
the connection between a motor neuron and a skeletal muscle
coating on axons that insulates the electrochemical signals
myelin
contiuum of efficacy
when a neurotransmitter binds and opens up a channel, it doesn’t just stay and keep it open, it jumps off and then could bind again somewhere else
dendrites
tree-like extensions off the soma that receive signals from other neurons
denervation supersensitivity
an up-regulation problem characterized increase in sensitivity of the postsynaptic cell caused when:
- Presynaptic cell decreases neurotransmitter influence – starves postsynaptic cell
- Postsynaptic cell increases receptor complement and becomes supersensitive to any of the remaining neurotransmitter around the cell (ex. phantom limb pain)
desensitization
- reduction in the sensitivity of the postsynaptic cell
- cell increases neurotransmitter influence- overwhelms post synaptic cell, which prompts the post synaptic cell to decrease receptor complement and become less sensitive to neurotransmitter presence (ex. drug addiction)
determine nerve cell shape and movement (i.e. actin, tubulin, elastin)
structural proteins
basics of cell biology
your DNA (genes) is transcribed into RNA (genetic message) which is translated into proteins (functional molecules)
DNA transcription
- produces mRNA (messenger RiboNucleic Acid)
- Single stranded copy of the the DNA molecule
- 4 bases (cytosine, guanine, adenine, and uracil [replaces thymine]) in a sequence that codes for the specific amino acid sequence of a protein
- Exits the nucleus and travels to the cytoplasm
do SSRIs create more protein reuptake pumps or do they create more serotonin for the reuptake pumps to hold on to?
- SSRIs are inhibitors, they stop serotonin from being taken up by the receptors so there is more floating around
- People respond well to SSRIs for the most part, they work really well, better for anxiety than depression.
- Four people with depression can present with the same symptoms but have different comorbidities/different underlying pathology, and drugs don’t work the same in those populations.
- We don’t have the diagnostic tools yet to test which one works best so we do symptom description diagnosis.
dopamine
small molecule neurotransmitter known for pleasure;
also addiction, movement and motivation. People repeat behaviors that lead to this chemical release.
each schwann cells dedicates itself to a small segment of an axon
schwann cell myelination
endocytosis
a piece of the membrane pinches back to form a new vesicle
endorphins
peptide neurotransmitters known for euphoria; released during exercise, excitement, and sex; reduces pain
enzyme
Substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction
epilepsy
loss of GABA producing neurons, treated with GABA stimulating drugs
exocytosis
fusion of the synaptic vesicle with the plasma membrane
family of neurotransmitters that include catecholamines (dopamine (DA), norepinephrine (NE)), and the indolamine, serotonin (5HT)
biogenic amines
filopedia
“finger feet” that come out of the growth cone
“finger feet” that come out of the growth cone
filopedia
fluid mosaic model
in a cell, the hydrophobic interior of the lipid bilayer acts as a very effective barrier to e-charged particles like water (H2O) and salt (Na+, K+) trying to get in and out of the cell.
different proteins in the membrane act as hydrophilic channels and pumps (functional components)
function of neurotransmitters
it is the property of a receptor, not the property of the molecule itself
fusion of the synaptic vesicle with the plasma membrane
exocytosis
GABA
small molecule neurotransmitter known for inhibition; calms firing nerves in the central nervous system; high levels improve focus, low levels cause anxiety; also contributes to motor control and vision.