Exam 1 ANS Pharm Flashcards
Cholinergic Receptors
M1
M2
M3
Nicotinic
M1
sweat glands, CNS, excitatory
M2
Heart, smooth muscle, presynaptic nerve
-inhibitory
M3
Exocrine glands, smooth muscle, vascular endothelium
Excitatory
Nictotinic
Nn> ganglia
Nm in the neuromuscular junction and ion channel
- opens channel and depolarizes the cell
Adrenergic Receptors
a1
a2
B1, B2,B3
D1
a1
smooth muscle,excitatory
a2
Pre-synaptic nerve terminal
inhbitory
are beta receptors excitartory or inhbitiory
all are excitatory
- stimulates cAMP
B1
heart, increases rate and contractility
B2
broncioles, heart, smooth muscle in skeletal blood vessels
B3
increase lipolysis in fat cells
D1
renal vascular bed, causes vasodialation
excitatory
what drugs affect cholinergic transmission
1. botulinum toxin inhibits cholinergic vesicle release decreasing levels 2. Muscarinic antagonists 3. Cholinesterase inh increasing Ach in the cleft
Drugs that affect adrenergic transmission
- Cocaine: block reuptake
- Amphetamines displace NE in nerve terminal reversing reuptake ^NE in the synaptic cleft
- Adrenergic Antagonists inhbit activation of receptors
PSN of heart and lungs
M2: lower HR and conduction
M3: bronchi constriction and increase mucus secretion
SNS of heart and lungs
B1/B2: increase HR and AV conduction and contractility
B2: bronciole dialation
PSNS in glands and Eyes
M3: increase salivation and tears
M3: miosis and near vision accomindation (due to contraction of circular muscle and contraction of cilliary muscle to create a round lense)
SNS for glands and Eyes
M1: sweating
a: salivation, mydriasis( due to contraction of radial muscle), nasal vasoconstriction
B: increase aqueous humor production
PNS for GI
M3: stimulate GI contraction and sphincter relaxation
M3: increase Gastric acid secretion
SNS for GI
a2/B2: GI relaxation (minor)
B2: liver glycogenolysis
Aqueous humor related receptors
B: increases the production
a2 decreases secretion and increases outflow
Why do we give cholinergic antagonist to pt with closed angle glaucoma
becuase binds to the M3 receptor
1. contracts circular muscle of iris
2. contracts cilliary muscle
creating space for the outflow
