Exam 1 ANS Pharm

Question 1

Cholinergic Receptors

Answer 1

M1
M2
M3
Nicotinic

Question 2

M1

Answer 2

sweat glands, CNS, excitatory

Question 3

M2

Answer 3

Heart, smooth muscle, presynaptic nerve

-inhibitory

Question 4

M3

Answer 4

Exocrine glands, smooth muscle, vascular endothelium

Excitatory

Question 5

Nictotinic

Answer 5

Nn> ganglia
Nm in the neuromuscular junction and ion channel
- opens channel and depolarizes the cell

Question 6

Adrenergic Receptors

Answer 6

a1
a2
B1, B2,B3
D1

Question 7

a1

Answer 7

smooth muscle,excitatory

Question 8

a2

Answer 8

Pre-synaptic nerve terminal

inhbitory

Question 9

are beta receptors excitartory or inhbitiory

Answer 9

all are excitatory

- stimulates cAMP

Question 10

B1

Answer 10

heart, increases rate and contractility

Question 11

B2

Answer 11

broncioles, heart, smooth muscle in skeletal blood vessels

Question 12

B3

Answer 12

increase lipolysis in fat cells

Question 13

D1

Answer 13

renal vascular bed, causes vasodialation

excitatory

Question 14

what drugs affect cholinergic transmission

Answer 14

1. botulinum toxin inhibits cholinergic vesicle release
decreasing levels 
2. Muscarinic antagonists 
3. Cholinesterase inh
increasing Ach in the cleft

Question 15

Drugs that affect adrenergic transmission

Answer 15

1. Cocaine: block reuptake
2. Amphetamines displace NE in nerve terminal reversing reuptake ^NE in the synaptic cleft
3. Adrenergic Antagonists inhbit activation of receptors

Question 16

PSN of heart and lungs

Answer 16

M2: lower HR and conduction
M3: bronchi constriction and increase mucus secretion

Question 17

SNS of heart and lungs

Answer 17

B1/B2: increase HR and AV conduction and contractility

B2: bronciole dialation

Question 18

PSNS in glands and Eyes

Answer 18

M3: increase salivation and tears
M3: miosis and near vision accomindation (due to contraction of circular muscle and contraction of cilliary muscle to create a round lense)

Question 19

SNS for glands and Eyes

Answer 19

M1: sweating
a: salivation, mydriasis( due to contraction of radial muscle), nasal vasoconstriction
B: increase aqueous humor production

Question 20

PNS for GI

Answer 20

M3: stimulate GI contraction and sphincter relaxation
M3: increase Gastric acid secretion

Question 21

SNS for GI

Answer 21

a2/B2: GI relaxation (minor)

B2: liver glycogenolysis

Question 22

Aqueous humor related receptors

Answer 22

B: increases the production

a2 decreases secretion and increases outflow

Question 23

Why do we give cholinergic antagonist to pt with closed angle glaucoma

Answer 23

becuase binds to the M3 receptor
1. contracts circular muscle of iris
2. contracts cilliary muscle
creating space for the outflow