Exam 1 Flashcards
What is part of Primary Hemostasis?
Blood vessels
What is necessary for platelet adhesion to collagen?
VWF
Where are most of the plasma procoagulant proteins produced?
Liver
On what does Factor VIII depend for stability?
VWF
What substance digest the fibrin clot after healing?
Plasmin
What role do coagulation factors play in the procoagulant process?
Bind to their specific activated serine protease to stabilize the protease and increase its activity.
What vitamin is essential for normal synthesis of proteins, thus enabling them to bind CA2+
Vitamin K
Absence of D dimers is useful for ruling: VTE disease
Thromboembolism
Plasminogen deficiency is associated with…
Increased Fibrinogen
Tissue plasminogen activator (TPA) activates ______ by converting plasminogen to plasmin, which gradually digest fibrin and restores blood flow.
Fibrinolysis
Factor X is part of the ______ Pathway
Common
Another name for Factor I is…
Fibrinogen
Which Factor stabilizes the fibrin polymers?
XIII
Which Factor is not dependent of Vitamin K?
V
Which Factor is used only in the Extrinsic Coagulation Pathway?
VII
Two children in the same family have recurrent, chronic bruising in multiple sites, repeated long-lasting epistaxis, and minor bleeding after dental work/ What type of disorder is most likely?
Generalized, congenital, systemic
What is the possible mechanism for bleeding in patients with severe liver disease?
Thrombocytopenia, Disseminated intravascular coagulation (DIC), or Inadequate production of procoagulants.
What is decreased in Disseminated intravascular coagulation (DIC)?
Fibrinogen
What are the primary roles of VWF?
Mediates platelet adhesion and carrier molecule for Factor VIII
What single-factor inherited deficiencies are most common as the cause for hemophilia?
Factor VIII
What is common in patients with severe hemophilia?
Serious anatomic bleeds into joints
What test is increased in a patient with severe Hemophilia A?
Partial Thromboplastin Time (PTT)
What is the purest form of Factor VIII that is available for treating a bleeding patient with Hemophilia A?
Recombinant Factor VIII concentrate
What is the best test to distinguish Hemophilia A from B or C?
Specific Factor assays
Which protein is the best test to distinguish moderate to severe liver disease from Vitamin K deficiency?
Factor IX concentrate
A 39-year-old male patient shows evidence of poor wound healing and a history of joint bleeding. What protein deficiency is most likely present?
Factor XIII
Screening test: PT, PTT, TT
