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Hemostasis > Exam 1 > Flashcards

Exam 1 Flashcards

1
Q

What is part of Primary Hemostasis?

A

Blood vessels

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2
Q

What is necessary for platelet adhesion to collagen?

A

VWF

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3
Q

Where are most of the plasma procoagulant proteins produced?

A

Liver

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4
Q

On what does Factor VIII depend for stability?

A

VWF

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5
Q

What substance digest the fibrin clot after healing?

A

Plasmin

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6
Q

What role do coagulation factors play in the procoagulant process?

A

Bind to their specific activated serine protease to stabilize the protease and increase its activity.

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7
Q

What vitamin is essential for normal synthesis of proteins, thus enabling them to bind CA2+

A

Vitamin K

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8
Q

Absence of D dimers is useful for ruling: VTE disease

A

Thromboembolism

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9
Q

Plasminogen deficiency is associated with…

A

Increased Fibrinogen

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10
Q

Tissue plasminogen activator (TPA) activates ______ by converting plasminogen to plasmin, which gradually digest fibrin and restores blood flow.

A

Fibrinolysis

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11
Q

Factor X is part of the ______ Pathway

A

Common

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12
Q

Another name for Factor I is…

A

Fibrinogen

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13
Q

Which Factor stabilizes the fibrin polymers?

A

XIII

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14
Q

Which Factor is not dependent of Vitamin K?

A

V

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15
Q

Which Factor is used only in the Extrinsic Coagulation Pathway?

A

VII

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16
Q

Two children in the same family have recurrent, chronic bruising in multiple sites, repeated long-lasting epistaxis, and minor bleeding after dental work/ What type of disorder is most likely?

A

Generalized, congenital, systemic

17
Q

What is the possible mechanism for bleeding in patients with severe liver disease?

A

Thrombocytopenia, Disseminated intravascular coagulation (DIC), or Inadequate production of procoagulants.

18
Q

What is decreased in Disseminated intravascular coagulation (DIC)?

A

Fibrinogen

19
Q

What are the primary roles of VWF?

A

Mediates platelet adhesion and carrier molecule for Factor VIII

20
Q

What single-factor inherited deficiencies are most common as the cause for hemophilia?

A

Factor VIII

21
Q

What is common in patients with severe hemophilia?

A

Serious anatomic bleeds into joints

22
Q

What test is increased in a patient with severe Hemophilia A?

A

Partial Thromboplastin Time (PTT)

23
Q

What is the purest form of Factor VIII that is available for treating a bleeding patient with Hemophilia A?

A

Recombinant Factor VIII concentrate

24
Q

What is the best test to distinguish Hemophilia A from B or C?

A

Specific Factor assays

25
Q

Which protein is the best test to distinguish moderate to severe liver disease from Vitamin K deficiency?

A

Factor IX concentrate

26
Q

A 39-year-old male patient shows evidence of poor wound healing and a history of joint bleeding. What protein deficiency is most likely present?

A

Factor XIII

Screening test: PT, PTT, TT

Hemostasis (1 decks)

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