Exam 1 Flashcards
Intravascular properties
- 6% body water
- Na+ - 140 mmol/L
- K+ - 4 mmol/L
Interstitial properties
- 14% body water
- Na+ - 140 mmol/L
- K+ - 4 mmol/L
Intracellular properties
- 40% body water
- Na+ - 8 mmol/L
- K+ - 151 mmol/L
molarity
moles/L
molality
moles/kg
osmolarity
osm/L
dissolved particles/L
osmolality
osm/kg
(dissolved particles/kg
vant hoff factor
number of particles a molecule dissolves into
Normal plasma osmolarity
275-295 mOsm/L
ecf osmolarity
280-290 mOsm/L
equivalents
millimoles * number of charges/molecule
%
g/100mL
normal urine output
1-2 mL/kg/hr
oliguria
less than 0.5 mL/kg/hr
mole
6.022 x 10^23 molecules
molar mass
weight of 1 mole of a compound
molecular weight
sum of atomic weight of all atoms
hyperkalemia treatments
1) calcium gluconate
2) insulin
3) stop k+ solutions/K+ sparing drugs
4) bicarb (below 7.2 pH)
calcium gluconate
- stabilizes myocytes
- prevents arrhythmia
Insulin
- Lowers serum K+
- Shifts K+ into cells
K+ holding drugs
- ACE inhibitors
- Beta blockers
- Potassium sparing diuretics
Diabetic crisis
- high blood glucose -> excess diuresis
- depletes fluids, K+, and Na+
treatment of diabetic crisis
- restore volume
- K+ supplementation
- insulin
Bicarb dose
mEq = 0.15 (base deficit) (weight)
KCl dose
mEq = (desired change) (TBV)
CaCl dose
10mg/kg = 0.1 increase
albumin
- not used for resuscitation
- treats edema
resuscitation fluids
- RBC or FFP (not NaCl)
- 500 mL bolus
Daily fluid maintenance requirements
-25-35 mL/kg/day
- 500 - 1000 mL of insensible losses
- 1000 - 1500 mL urine output
early phase fluid shift following injury
- water is retained (ADH/aldosterone secretion)
- oliguria common after surgery
- negative charges lost (K+ shift)
late phase fluid shift following injury
- anabolic - cells in sponge phase
- NA+ and H2O move into ECF
- K+ reuptake into cells