Exam 1

Question 1

what is an autocoid

Answer 1

an endogenous compound with a brief lifetime that acts near the site of synthesis

Question 2

what are the four main categories of autocoids

Answer 2

biological active amines, endogenous vasoactive peptides, eicosanoids and cytokines

Question 3

what major autocoid reacts to allergies and anaphylaxis

Answer 3

histamine

Question 4

what receptor does histamine act on

Answer 4

H1

Question 5

what receptors do GI secretions of HCl act on

Answer 5

H2

Question 6

autocoids that act on neuromodulation and neurotransmitters in CNS act on what receptors

Answer 6

H1 and H1/H3

Question 7

autocoids in the cardiovascular system can cause contraction of large vessels, dilation of arterioles, increased capillary permeability with slight tachycardia by acting on what receptors

Answer 7

H1 and H2

Question 8

autocoids can cause bronchial smooth muscle contraction by acting on what receptors

Answer 8

H1

Question 9

autocoids cause arteriolar constriction in the cardio system of what animal

Answer 9

rodents

Question 10

autocoids cause large vessel constriction and increased blood pressure in what animal

Answer 10

rabbits

Question 11

autocoids cause vasodilation of microcirculation and a decrease in BP of what animal

Answer 11

carnivores

Question 12

autocoids can cause an increase in gastric secretion by acting on what receptors

Answer 12

H2 and H1

Question 13

what is the main source of histamine in the body

Answer 13

histadine

Question 14

where is the largest storage pool for histamine in the body

Answer 14

mast cells (stimulated release) and rapidly synthesized pools (constant release)

Question 15

what enzyme terminates the action of histamine

Answer 15

histamine methyltransferase and monoamine oxidase