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Lab Animal Science + Bioethics > Exam 1 > Flashcards

Exam 1 Flashcards

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Biology 101 flashcards
1
Q

This gl is ø a specific pheromone producer gl:

A

Rabbit’s face gl.

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2
Q

Which is ø a method for genetic quality control of lab animals?

A

Back gross breeding.

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3
Q

Drawback of preference tests:

A

Animals choose in base of short term cond.

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4
Q

Which measurement is used to express E requirement of lab animals?

A

Metabolic BW.

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5
Q

Sentinels are:

A

Animals used to evaluate a grp’s health status.

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6
Q

Which method would you use to get 1mL of blood from a rat?

A

Cardiac puncture.

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7
Q

You cannot buy this type of diet from a commercial supplier:

A

Chemically defined diet.

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8
Q

ø alpha2- agonist:

A

Tolmetine.

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9
Q

ø inherited disease of rat:

A

Hypo- acidosis.

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10
Q

The basic method of rodent phenotyping is to look for:

A

Chromosoma test.

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11
Q

ø part of refinement of animal experimentation:

A

Alternatives to animal use.

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12
Q

Which animals are covered by 63/2010 EEc directive?

A

Vertebrates + Cephalipodes.

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13
Q

GLP ø concerned about cond. under which lab:

A

Are build.

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14
Q

Which sp. can die after oral penicillin treatment?

A

Guinea pig.

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15
Q

1 of them is an important mechanism of nutrigenomics:

A

Changing the signaling pathway.

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16
Q

Acute toxicity test has an invasiveness category of __ pain:

A

Severe.

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17
Q

Maintenance E requirements of lab animals:

A
  1. 45 MJ DE x W0.75.
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18
Q

This disease is ø a zoonosis:

A

Ringtail.

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19
Q

The recommended nutrient allowances:

A

Ensure the reproduction + longevity of animals.

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20
Q

Cannot be stage of mouse genital + urinary syndrome:

A

Ulceration.

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21
Q

Quarantine period ø determined by:

A

Number of animals.

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22
Q

Which sp. has a tied skin, so cannot grab it without causing pain to animal?

A

Guinea pig.

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23
Q

ø physical euthanasia method:

A

Maceration.

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24
Q

Which sp. is ø a member of Rodentia genus?

A

Marmoset.

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25
Q

OECD do ø deal questions about:

A

Validation of in vitro methods.

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26
Q

Gerbil is a good model for:

A

Epilepsy aorta.

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27
Q

The animal cannot be examined with US:

A

Golden hamster.

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28
Q

ø true for chronic mycoplasmosis of mice:

A

Zoonosis.

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29
Q

The closes sp. to Syrian hamster is taxonomy is:

A

Gerbil.

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30
Q

Good sp. to use for auditory research:

A

Chinchilla.

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31
Q

Breeding techniqure which is ø used to maintain an out- bred stock:

A

Brother- Sister mating.

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32
Q

A contaminated breeding colony ( line) should be:

A

Euthanised.

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33
Q

In reproductive toxicology, ø acceptable treatment:

A

Used only for parents before mating?

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34
Q

It can be used for intradermal inj:

A

Mice ear.

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35
Q

Pasteurella pneumotropica does ø attack:

A

Brain.

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36
Q

Environmental enrichment should ø be done:

A

Just for human fun.

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37
Q

How would your restrain a gerbil?

A

Hand around the chest.

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38
Q

Who will decide on institute level if an animal experiment was necessary or ø?

A

Ethical committee ( Animal Welfare Body).

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39
Q

It is ø a zoonosis:

A

Sendai virus disease.

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40
Q

This female embryo in a rat achieve breeding maturity:

A

1 mnth.

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41
Q

The basic method of rodent sexing is to look for:

A

Ano- genital distance.

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42
Q

The recommended nutrient allowances:

A

Ensure the optimum functioning of animals.

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43
Q

The main body of Lab Animal Science of the World:

A

CLAS.

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44
Q

The closest sp to Syrian hasmter in taxonomy is:

A

Gerbil.

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45
Q

What ‘ Environmental Enrichment’ means in lab?

A

To give bedding material/ toys to experimental animal if possible.

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46
Q

Feeding rancid feed and/ or vit E deficient feed may cause:

A

Dermatitis.

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47
Q

Zebradanio is:

A

Omnivore.

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48
Q

It is an alternative use of animals in experiments:

A

Database search + meta- analysis.

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49
Q

SC injury has a severity caategory of __ pain:

A

Minor.

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50
Q

Which 3 words called the 3 Rs by Russel + Burch?

A

Reduction, Replacemnet, Refinement.

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51
Q

It is ø true about euthanasia:

A

Can be used to get large amt of blood out of an animal.

52
Q

What does ‘ knock out animal’ mean:

A

Trangenic animal.

53
Q

Which method would you use to get a drop of blood from mice?

A

Retro- orbital puncture.

54
Q

Which name indicates an outbred stock?

A

Ir: NMRI.

55
Q

You cannot use this method for euthanasia on rat:

A

Ketamine.

56
Q

What is the best equipment to maintain a trangenic colony in?

A

Base colony in different countries.

57
Q

Which sp. has only provoked ( stimulated) ovulation?

A

Ferret.

58
Q

What does the expression ‘ inbred strain’ mean:

A

Brother- sister mating through at least 20 generations.

59
Q

Which sp. is the best in atherosclerosis research?

A

WHHL- rabbit; Notes- Gerbil.

60
Q

You can find a ‘ sacculus rotundus or ampulla ilei’ in the:

A

Rabbit.

61
Q

This gl is a specific pheromone producer gl:

A

Hamster’s lat gl.

62
Q

Which sp has a gallbladder?

A

Golden hamster.

63
Q

What does SPF mean?

A

Specific Pathogen Free.

64
Q

How would you restrain a rat for /oral dosing?

A

By grabbing the skin on abck + neck.

65
Q

Which sentence is ø true about ‘ Environment Enrichment’ ?

A

Device in case that animal can control.

66
Q

Gnotobiotic ( = Axenic) animals:

A

Germ free.

67
Q

What does rederivation mean?

A

Production of germ- free strain by embryo transfer.

68
Q

In the practice, it is ø possible to produce germ- free colony from this sp:

A

Duck.

69
Q

Which would be the best feeding regime in an experiment?

A

Ad lib.

70
Q

What is well- being?

A

State of physical + psychological harmony of animal with it’s int + ext environment.

71
Q

Which vein can be used for IV inj on ferret?

A

Jugular vein.

72
Q

How would you restrain a rabbit?

A

By grabbing as much skin as possible on back.

73
Q

You cannot use this method for euthanasia on new-born, nest- living animals:

A

CO2 inhalation.

74
Q

Which method would you use to get 10 mL of blood from an adult rat?

A

Preparation of abd aorta.

75
Q

Which mouse strain is sensitive to Pneumocystis carini?

A

Swiss.

76
Q

Which is ø necessary before transport of rodent?

A

Fasting.

77
Q

When this phenomenon disappears, the narcosis ends with death:

A

Cornea reflex.

78
Q

It is ø true about euthanasia:

A

Should be cheap.

79
Q

1 is ø true about the co- isogenic strains:

A

It can only be maintained in a homozygous form.

80
Q

Dog is ø a good model for:

A

Cardiovascular atherosclerosis.

81
Q

Mini- Sus has a live weight of:

A

20 - 45 kg.

82
Q

Experimental design cannot be:

A

Cross- breeding.

83
Q

The basal circadian rhymth, is:

A

Dependent from the gen expression of a protein.

84
Q

Melatonin is produced by:

A

Pineal gl.

85
Q

This sp mostly used in viral respiratory behaviour:

A

Apathy/ Aggression.

86
Q

Well- being cannot be measured by:

A
  • Clinical assessment.
  • Physiological parameters.
  • Grimace score.
  • Reproductive state.
87
Q

Which environment is good for animals?

A

Classical music.

88
Q

Which tissue is the least sensitive to suffering?

A

Brain tissue.

89
Q

The naked mole rat has an extra- ordinary long lifespan because of:

A

Special hyaluronan which prevent cancer.

90
Q

The co- efficient on inbreeding ( F):

A

Means the franction of genes that get fixed in a homozygous state.

91
Q

It is inherited disease of some mouse strains:

A

Deafness.

92
Q

Which is a member of Poxviridae?

A

Ectomelia virus.

93
Q

Ringtail is caused by:

A

Too low relative humidity.

94
Q

ø part of refinement of animal experimentation:

A

Hair colour.

95
Q

The eharing range of rodents:

A

0.5/ 1 - 100/ 120 kHz.

96
Q

Which sp has 1 pair teats?

A

Guinea pig.

97
Q

The 2 important words for animals concerning the pain feeling ( Weiss- trail):

A

Predictability + controllability.

98
Q

Mousepox is

A

Caused by Ectomelia.

99
Q

It is ø physical euthanasia method:

A

Cooling in refrigerator.

100
Q

The African clawed for ( Xenopus):

A

Shows mating behaviour after Hcg inj.

101
Q

The axolotl is ø:

A

Reaches adulthood after a complete metamorphosis.

102
Q

Lab animals- except the guinea pig- usually adjust their feed intake to satisfy their:

A

E requirement.

103
Q

Which sp can die after oral Ab treatment?

A

Guinea pig + rabbit.

104
Q

The role of PPAR is to:

A

Burn fats.

105
Q

1 of the following has ø anti-cancer effect:

A

Fe.

106
Q

1 of them is an important mechanism of epigenomics:

A

Methylation of DNA.

107
Q

Zebrafish has a lifespan of __ year:

A

6 - 8.

108
Q

1 of them has ø role in epigenomics:

A

Change of base in DNA.

109
Q

The role of __ is a fine regulation of protein synthesis in cell:

A

miRNA/ siRNA.

110
Q

In some cases the epigenetic changes may be inherited:

A

IF the effects act during the germ- cell proliferation ( ‘ time window’).

111
Q

You can find neotomy at:

A

Axolotl.

112
Q

Pheromones are detected by:

A

VNO.

113
Q

1 is true about the ferret:

A

We can prevent the const estrus by using GnRH agonist implants.

114
Q

The cephalopods:

A

are under the protection og 2010/63/EU Directive since 2013.

115
Q

Always consider using F1 hybrid because:
- Their biological response is more variable than the parental strains nor their biological response is more uniform than the parental strains.

A

Neither.

116
Q

1 of the statements is true:

A

Animals in an outbred stock are anisogenic.

117
Q

A chromorhnydachyrrhea:

A

Vit A deficiency.

118
Q

It can go through the uteral wall:

A

Mouse mammary tmour.

- LCM.

119
Q

CH ingestion:

A

Stimualte the FA synthase gene expression.

120
Q

May increase the mitochondria number:

A

Resveratrol.

121
Q

The most used model for drug metabolism study for humans:

A

Macaco.

122
Q

Shortly describe the pyramide conception, with e.g:

A
  • Computer- Synthetize compounds.
  • Bacteria- Test for teratogenicity.
  • Cell culture- Eliminate harmful compounds.
  • Invertebrates, Fish, Mammals, non- human primates.
  • Human.
123
Q

Explain the epigenetics mechanism of action.

A
  • Modifications.
  • ø change the genome itself.
  • May be inherited.
  • Influenced by outside stimuli.
124
Q

Describe the naked mole as an animal model.

A
  • Have a gene which conserves collagen.
  • ø age + get tumors.
  • Lifespan of 20 - 30 yrs.
  • Complex social system + hierarchy.
  • Best model for aging + cancer studies.
125
Q

Weis experiments: 2 series of trials.

A
  • Showed corticothalamic blunting - “ stress analgesia”.
  • Production of endogenous opioids in stressful situations which increases the pain threshold.
  • 1st trial: 3 grps of rats.
    > Received light, then 10s afterwards received an electric shock to tail; went on for 1hr.
    >Received light + electric shock before + after, ø set timing.
    > ø light, ø shock ( control grp).
  • Then checked for physiological state.
    > Grp 3 was normal ( control).
    > Grp 1 was also normal because they had time to anticipate pain + produce endogenous opioids + increase their pain threshold
    > Grp 2 was miserable + in pain.
  • 2nd trial: + grp 3, same experiment but received a switch to stop the electric shock.
    > the results were the same, because grp 1 could anticipate the shock and flip the switch.
126
Q

Explain the pain scoring system for Glires.

A
  • 0 pts= none.
  • 1 pt= Mild.
  • 2 pts= Moderate.
  • 3 pts= Severe.
  • Based on appearance, behaviour, pulse, appetite/ drinking, cardiovascular, digestive + nervous systems.
  • 0 - 4= normal.
  • 5 - 9= needs analgesia.
  • 10 - 14= moderate pain, possible need to terminate trial.
  • 15- 20= ø physiological, stop experiment.

Lab Animal Science + Bioethics (1 decks)

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