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COB Immunology > Exam 1 > Flashcards

Exam 1 Flashcards

1
Q

Early phagocytosis and killing of microbes=?

A

Neutrophils

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2
Q

Efficient phagocytosis and killing of microbes, secretion of cytokines that stimulate inflammation=?

A

Macrophages

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3
Q

Lysis of infected cells, activation of macrophages=?

A

NK cells

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4
Q

Killing of microbes, opsonization of microbes, activation of leukocytes= what circulating effector proteins?

A

Complement

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5
Q

Opsonization of microbes, activation of complement (lectin pathway), based on unique structure= what circulating effector proteins?

A

Mannose binding lectin

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6
Q

Opsonization of microbes activation of complement= what circulating effector proteins?

A

C-reactive protein (pentraxin)

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7
Q

Inflammation= what cytokine

A

TNF, IL-1, chemokines

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8
Q

Resistance to viral infection= what cytokine

A

IFN- alpha and beta

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9
Q

Macrophage activation= what cytokine

A

IFN-y

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10
Q

IFN-y production by NK cells and T cells= what cytokine

A

IL-12

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11
Q

Proliferation of NK cells = what cytokine

A

IL-15

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12
Q

Control of inflammation= what cytokine

A

IL-10, TGF-B

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13
Q

What happens to inflammation when chemokines are at their highest concentration?

A

Most inflammation

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14
Q

What toll-like receptors (TLRs) are recognized on extracellular pathogens?

A

TLR-1, -2, -4, -5, -6

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15
Q

What toll-like receptors (TLRs) are recognized on extracellular pathogens?

A

TLR-3, -7, -8, -9

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16
Q

For the receptor TLR1 what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A
  1. Lipopeptides
  2. Bacteria
  3. Monocytes, dendritic cells, eosinophils, basophils, mast cells.
  4. Plasma Membrane
17
Q

For the receptor TLR2 heterodimer what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A
  1. GPI
  2. Parasites, trypanosomes
  3. Monocytes, dendritic cells, eosinophils, basophils, mast cells.
  4. Plasma Membrane
18
Q

For the receptor TLR2 what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A
  1. Lipoteichoic acid
  2. Gram positive bacteria
  3. Monocytes, dendritic cells, eosinophils, basophils, mast cells.
  4. Plasma Membrane
19
Q

For the receptor TLR6 heterodimer what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A
  1. Zymosan
  2. Yeasts (fungi)
  3. Monocytes, dendritic cells, eosinophils, basophils, mast cells.
  4. Plasma Membrane
20
Q

For the receptor TLR3 what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A
  1. Double stranded viral RNA
  2. Viruses, West nile virus
  3. NK cells
  4. Endosomes
21
Q

For the receptor TLR4: TLR4 homodimer what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A
  1. Lipopolysaccharide
  2. Gram Negative bacteria
  3. Macrophages, dendritic cells, mast cells, eosinophils
  4. Plasma Membrane
22
Q

For the receptor TLR5 what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A
  1. Flagellin
  2. Motile bacteria having a flagellum
  3. Intestinal epithelium
  4. Plasma Membrane
23
Q

For the receptor TLR7 what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A
  1. Single stranded viral RNAs
  2. Viruses (HIV)
  3. Plasmacytoid dendritic cells, NK cells, eosinophils, B cells
  4. Endosomes
24
Q

For the receptor TLR8 what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A
  1. Single stranded viral RNAs
  2. Viruses influenza
  3. NK cells
  4. Endosomes
25
Q

For the receptor TLR9 what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A
  1. Unmethylated CpG-rich DNA
  2. Bacteria, viruses, herpes viruses
  3. Plasmacytoid dendritic cells, B cells, eosinophils, basophils
  4. Endosomes
26
Q

For the receptor TLR10 homodimer and heterodimers with TLR1 and 2 what is the:

  1. Ligand:
  2. Microorganisms recognized:
  3. Cells carrying receptor:
  4. Cellular location of receptor:
A

1 .Unknown

  1. Unknown
  2. Plasmacytoid dendritic cells, B cells, basophils, eosinophils
  3. Unknown

COB Immunology (1 decks)

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