Exam 1 Flashcards
Tachyphylaxis is defined as which of the following?
Tolerance which develops rapidly
An abnormality in the fetus caused by toxic xenobiotic taken by the mother before pregnancy is termed which of the following?
Mutagenesis
The number one most important treatment of poisoning by overdose or ingestion of a toxic chemical in which
of the following?
Gastric lavage
The interaction between aspirin and warfarin in the blood stream is an example of which of the following
Distribution
An antidote which accelerates conversion of a toxic agent to nontoxic metabolites is which of the following examples?
Acetylcysteine and Acetaminophen
Giving vitamin K as an antidote to warfarin is an example of which of the following specific antidotal
mechanisms?
Antidote restores normal functioning by bypassing the effect of the toxic agent
One of the differences between an allergy and a toxicity is that an allergy:
Needs prior contact with allergen
A patient does not start breathing following surgery as a normal patient would in the post operative room.
The patient was given a drug to help the clinician intubate the patient in order to be put on respirator. The
most likely cause of lack of breathing in which of the following?
Anesthesiologist gave too much anesthetic
The most effective treatment for anaphylaxis is:
Epinephrine
Tachyphylaxis is defined as which of the following?
Tolerance which develops rapidly
Parkinson’s disease is characterized by an in system?
Dopamine and acetylcholine
Therapy is especially directed toward which of the following Parkinson’s disease?
Augmentation and restoration of dopamine
The most effective treatment for Parkinson’s is a combination of which drugs?
Levodopa-carbidopa (Sinemet)
Which of the following vitamins is necessary for the conversion of Dopa to Dopamine in the brain?
Vitamin B6
Which of the following drugs prevents the conversion of Dopa to Dopamine in the periphery but does not cross the BBB itself, thereby decreasing the need for a high dose of the most important drug used in Parkinson ’s disease and decreasing the side effects?
Carbidopa
A patient with dry mouth, blurred vision, constipation, urinary retention, sweating, insomnia, and
tachyarrhythmia. What type of drug do you give the Parkinson’s patient?
sympathetic blocker
Not muscarinic blocker (symptoms are side effects of these), antidepressants, or
sympathetic/serotonin agonist
All the following are the advantages to the use of dopamine agonists as initial therapy in Parkinson’s instead
of levodopa and Carbidopa except:
Conversion is necessary to another drug which is then active against the disease
A Parkinson’s patient becomes tolerant to Levodopa and you want to increase the amount of Dopamine in the brain. You have already tried Carbidopa with some…Selegiline
Inhibits MAO-II
the antidote which blocks the formation of a toxic agent from its precursor is the way the following
drug/antidote work
Methanol/Ethyl alcohol
True or false. An allergy calls for the need for prior contact
True
Select the FALSE statement regarding the oral Antidiabetic drugs.
They decrease the damage that glucose and insulin do to target organ systems
The most important type of nonspecific therapy for poisoning or overdose toxicity is which of the following?
Maintain respiration and circulation
The best way to rid the GI tract of poisons is which of the following
Gastric lavage
True or false. An allergy is different from a drug toxicity in that an allergy is dose dependent (the larger the
dose, the greater the response)
False
Which of the following type of tolerance is exemplified by reduced GI absorption?
Pharmacokinetic
True or False. Selective toxicity means that the drug affects the microbe, not the human host
True
What effects does syrup of ipecac cause?
Vomiting
