Exam 1

Question 1

Tachyphylaxis is defined as which of the following?

Answer 1

Tolerance which develops rapidly

Question 2

An abnormality in the fetus caused by toxic xenobiotic taken by the mother before pregnancy is termed which of the following?

Answer 2

Mutagenesis

Question 3

The number one most important treatment of poisoning by overdose or ingestion of a toxic chemical in which
of the following?

Answer 3

Gastric lavage

Question 4

The interaction between aspirin and warfarin in the blood stream is an example of which of the following

Answer 4

Distribution

Question 5

An antidote which accelerates conversion of a toxic agent to nontoxic metabolites is which of the following examples?

Answer 5

Acetylcysteine and Acetaminophen

Question 6

Giving vitamin K as an antidote to warfarin is an example of which of the following specific antidotal
mechanisms?

Answer 6

Antidote restores normal functioning by bypassing the effect of the toxic agent

Question 7

One of the differences between an allergy and a toxicity is that an allergy:

Answer 7

Needs prior contact with allergen

Question 8

A patient does not start breathing following surgery as a normal patient would in the post operative room.
The patient was given a drug to help the clinician intubate the patient in order to be put on respirator. The
most likely cause of lack of breathing in which of the following?

Answer 8

Anesthesiologist gave too much anesthetic

Question 9

The most effective treatment for anaphylaxis is:

Answer 9

Epinephrine

Question 10

Tachyphylaxis is defined as which of the following?

Answer 10

Tolerance which develops rapidly

Question 11

Parkinson’s disease is characterized by an in system?

Answer 11

Dopamine and acetylcholine

Question 12

Therapy is especially directed toward which of the following Parkinson’s disease?

Answer 12

Augmentation and restoration of dopamine

Question 13

The most effective treatment for Parkinson’s is a combination of which drugs?

Answer 13

Levodopa-carbidopa (Sinemet)

Question 14

Which of the following vitamins is necessary for the conversion of Dopa to Dopamine in the brain?

Answer 14

Vitamin B6

Question 15

Which of the following drugs prevents the conversion of Dopa to Dopamine in the periphery but does not cross the BBB itself, thereby decreasing the need for a high dose of the most important drug used in Parkinson ’s disease and decreasing the side effects?

Answer 15

Carbidopa

Question 16

A patient with dry mouth, blurred vision, constipation, urinary retention, sweating, insomnia, and
tachyarrhythmia. What type of drug do you give the Parkinson’s patient?

Answer 16

sympathetic blocker
Not muscarinic blocker (symptoms are side effects of these), antidepressants, or
sympathetic/serotonin agonist

Question 17

All the following are the advantages to the use of dopamine agonists as initial therapy in Parkinson’s instead
of levodopa and Carbidopa except:

Answer 17

Conversion is necessary to another drug which is then active against the disease

Question 18

A Parkinson’s patient becomes tolerant to Levodopa and you want to increase the amount of Dopamine in the brain. You have already tried Carbidopa with some…Selegiline

Answer 18

Inhibits MAO-II

Question 19

the antidote which blocks the formation of a toxic agent from its precursor is the way the following
drug/antidote work

Answer 19

Methanol/Ethyl alcohol

Question 20

True or false. An allergy calls for the need for prior contact

Answer 20

True

Question 21

Select the FALSE statement regarding the oral Antidiabetic drugs.

Answer 21

They decrease the damage that glucose and insulin do to target organ systems

Question 22

The most important type of nonspecific therapy for poisoning or overdose toxicity is which of the following?

Answer 22

Maintain respiration and circulation

Question 23

The best way to rid the GI tract of poisons is which of the following

Answer 23

Gastric lavage

Question 24

True or false. An allergy is different from a drug toxicity in that an allergy is dose dependent (the larger the
dose, the greater the response)

Answer 24

False

Question 25

Which of the following type of tolerance is exemplified by reduced GI absorption?

Answer 25

Pharmacokinetic

Question 26

True or False. Selective toxicity means that the drug affects the microbe, not the human host

Answer 26

True

Question 27

What effects does syrup of ipecac cause?

Answer 27

Vomiting