Exam 1 Flashcards
What are the 4 primary tissue components
Collagen
Elastin
Ground substance
Water
What’s special about collagen
Continuous metabolic turnover through growth and maturity.
At maturity the fibers become MORE STABLE
Collagen is made by?
Fibroblasts
They are aligned in the extracellular matrix in a parallel arrangement
What can collagen do?
Stretch 110%
Increases ligaments size and strength
What does degeneration in ligaments result in?
Decrease in
Diameter Density Number Mass Metabolism
How far can elastin stretch?
150% from original length without breaking
What is ground substance
Aka Cement Substances
Water consists of 60-70% of total connective tissue content
What are the 4 main GAGs
Hyaluronic acid
Chondroitin 4- sulfate
Chondroitin-6-Sulfate
Dermatan Sulfate
Glucosamine is found in high concentration within GAGs *
What is the function of water in collagen
It acts as a powerful lubricant
Also helps maintain a CRITICAL DISTANCE between collagen fibers
What is tissue biomechanics
The development, maintenance, and re molding of tissue as well as the development of damage and disease
Ability to react to external forces
What are the types of mechanical forces acting on tissue
Compression Tension Shear Torsion Bending
What is compression
When a load produces forces that push the material together
What is tension
When a structure is stretched longitudinally
What is shear
Forces acting parallel to each other in opposite directions
What is torsion
Forces twisting/rotating in opposite directions about the long axis
What is bending
Combination of tensile and compressive loads
Compression is almost constantly acting on what……….
The vertebral body and the inter vertebral disc
What are compression injuries
Bruises
Crushing injuries
Compression fractures
Pinching
Tension occurs during what kind of movements
Rotational
The annular fibers tend to bear the tensile loads
What are examples of tension injuries
Sprain/strain injuries
Avulsion fractures
Nerve traction injuries
What type of bone are most at risk for fracture from shear forces
Cancellous bones
Ex. Femoral condyles and tibial plateaus
What resist the shear forces in the spine?
The facet joints and the annulus fibrosis
What are examples of shear injuries
Brain injuries
Tibiofemoral translation such as ACL and PCL
Blisters
Spine injuries
What elements of the spine resist torsion and fail
Facets
Pars interarticularis
Capsular tears
Tears in the annulus
Spiral fractures of long bones are an example of ___________________
Torsional load failure
What are the most common responses to mechanical loading of tissues
Deformation
Growth and remolding
Failure
Deformation is when the object may translate or rotate unless in static equilibrium when results in local shape change
True or false
TRUE
What does the extent of deformation depend on
Material properties
Size and shape of object
Environmental factors
Forces
What is stress
The external force trying to deform the material
Measure the intensity of the force
What is strain
Magnitude of deformation from applied stress
Measure of the degree of deformation
Stress is what is ______ to an object while strain is _______ the object responds
Done, how
In addition to strain in direction of the applied stress there is also strain in an _______________ direction of loading
Orthogonal
What are three other qualities of tissues
Strength
Ductility
Toughness
What is strength
The maximum stress a tissue can withstand without permanent deformation