Exam 1 Flashcards
Acetylcholine
Muscarinic Receptor Agonist
Nicotinic Receptor agonist
Bethanechol
Muscarinic receptor agonist (quaternary)
-Oral, used for tx of non-obstructive urinary retention/ paralytic ileus
Pilocarpine
Muscarinic receptor agonist (tertiary)
-Long acting topical, used for glaucoma, Xerostomia (limited patient acceptance)
Atropine
Muscarinic receptor ANtagonist
Physostigmine
AChE inhibitor
- Myasthenia gravis
- Tx for antimuscarinic drug intoxication (Enters CNS, but narrow Therapeutic index limits use)
Neostigmine
AchE inhibitor
- Oral
- Tx for urinary retention/paralytic ileus (w/o obstruction)
- Myasthenia gravis
Edrophonium
AchE inhibitor
-Diagnostic in Tensilon test for Myasthenia gravis
Organophosphates
AchE inhibitor (Pesticides!!)
Pralidoxime
Cholinesterase reactivator (tx for organophosphate poisoning)
Epinephrine
Nonselective (a1, a2, b1, b2)
Norepinephrine
(a1, a2, b1)
Phenylephrine
a1 selective
Clonidine
A2 selective
Isopreterenol
B1/B2 non-selective
Albuterol
B2 selective
Dopamine
D1/D2 direct agonist PLUS indirect adrenergic (NE release)
Pseudoephedrine
Indirect Adrenergic agonist
MAOI’s
Side effect: Antiadrenergic/sympatholytic ( leads to increase in false transmitter synthesis)
Doxazosin
A1 adrenergic antagonist
Metoprolol
B1 selective antagonist
Labetalol
A1 and B1/B2 antagonist
Botulinium toxin
Inhibits acetylcholine release (cleaves SNARE complex)
Black widow spider venom
Increases acetylcholine release
Acacurium
nicotinic AchR antagonists - NMJ competitive blocker, isoquinoline derivative
Rocuronium
nicotinic AChR antagonist, NMJ competitive blocker, steroid derivative
Succinylcholine
NMJ deploarizing blocker (Mimics Acetylcholine but isn’t broken down by AchE)
