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Neuro Exam 1 Drugs/Targets > Exam 1 > Flashcards

Exam 1 Flashcards

1
Q

Acetylcholine

A

Muscarinic Receptor Agonist

Nicotinic Receptor agonist

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2
Q

Bethanechol

A

Muscarinic receptor agonist (quaternary)

-Oral, used for tx of non-obstructive urinary retention/ paralytic ileus

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3
Q

Pilocarpine

A

Muscarinic receptor agonist (tertiary)

-Long acting topical, used for glaucoma, Xerostomia (limited patient acceptance)

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4
Q

Atropine

A

Muscarinic receptor ANtagonist

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5
Q

Physostigmine

A

AChE inhibitor

  • Myasthenia gravis
  • Tx for antimuscarinic drug intoxication (Enters CNS, but narrow Therapeutic index limits use)
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6
Q

Neostigmine

A

AchE inhibitor

  • Oral
  • Tx for urinary retention/paralytic ileus (w/o obstruction)
  • Myasthenia gravis
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7
Q

Edrophonium

A

AchE inhibitor

-Diagnostic in Tensilon test for Myasthenia gravis

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8
Q

Organophosphates

A

AchE inhibitor (Pesticides!!)

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9
Q

Pralidoxime

A

Cholinesterase reactivator (tx for organophosphate poisoning)

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10
Q

Epinephrine

A

Nonselective (a1, a2, b1, b2)

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11
Q

Norepinephrine

A

(a1, a2, b1)

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12
Q

Phenylephrine

A

a1 selective

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13
Q

Clonidine

A

A2 selective

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14
Q

Isopreterenol

A

B1/B2 non-selective

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15
Q

Albuterol

A

B2 selective

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16
Q

Dopamine

A

D1/D2 direct agonist PLUS indirect adrenergic (NE release)

17
Q

Pseudoephedrine

A

Indirect Adrenergic agonist

18
Q

MAOI’s

A

Side effect: Antiadrenergic/sympatholytic ( leads to increase in false transmitter synthesis)

19
Q

Doxazosin

A

A1 adrenergic antagonist

20
Q

Metoprolol

A

B1 selective antagonist

21
Q

Labetalol

A

A1 and B1/B2 antagonist

22
Q

Botulinium toxin

A

Inhibits acetylcholine release (cleaves SNARE complex)

23
Q

Black widow spider venom

A

Increases acetylcholine release

24
Q

Acacurium

A

nicotinic AchR antagonists - NMJ competitive blocker, isoquinoline derivative

25
Q

Rocuronium

A

nicotinic AChR antagonist, NMJ competitive blocker, steroid derivative

26
Q

Succinylcholine

A

NMJ deploarizing blocker (Mimics Acetylcholine but isn’t broken down by AchE)

Neuro Exam 1 Drugs/Targets (1 decks)

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