Exam 1

Question 1

When temperature increases what does solubility do?

Answer 1

Solubility also increases

Question 2

Does a drug with high melting point have high or low solubility?

Answer 2

low solubility

Question 3

Lower pH=? and solubility in H20?

Answer 3

Increase H+ and decreased solubility in H2O

Question 4

pKa=?

Answer 4

pKa= -log (Ka)

Question 5

pH=?

Answer 5

-log(H+)

Question 6

How does particle size affect solubility?

Answer 6

Solid drugs that have small particle size are more soluble

Question 7

What is a solution?

Answer 7

A SOLUTION is a type of DISPERSION from a physical mixture of two or more substances.

Question 8

What are the factors that control the solubility of a solid?

Answer 8

Temperature, melting point, molar heat of fusion, heat of solution, pH of solution, Physical and chemical properties of solute and solvent, particle size and form, nature and magnitude of intramolecular forces.

Question 9

Name 3 non electrolyte non-dissociating molecules

Answer 9

Ethanol, Propylene glycol, glycerin

Question 10

Weak electrolytes?

Answer 10

Weak base and weak acid

Question 11

Strong electrolyte?

Answer 11

NaCl Strong dissociation

Question 12

What are salts?

Answer 12

Neutralization products of acid base reactions

Question 13

Examples of strong acids

Answer 13

HNO3, H2SO4, HClO4

Question 14

Weak acids

Answer 14

B(OH)3, H2CO3, H3PO4, H2SO3

Question 15

When pH= pKa

Answer 15

50% of the drug is in the ionized form